Clusterin: It’s Implication in Health and Diseases.

Abstract

Clusterin (CLU) is a glycoprotein with a nearly ubiquitous tissue distribution that has been reported to be implicated in several physiological processes as well as in many pathological conditions including ageing, diabetes, atherosclerosis, degenerative diseases and tumorigenesis including tumors of prostate, colon, and breast. Two distinct CLU mRNA isoforms,the conventional secreted form of CLU (sCLU) is thought to be a component of high density lipoprotein-cholesterol. sCLU functions as a chaperone for misfolded proteins and it is thought to promote survival by reducing oxidative stress. Nuclear CLU, formed by alternative splicing, is responsible for promoting apoptosis via a Bax-dependent pathway. This review will summarizes our understanding of the importance of CLU in various physiological functions and speculate on its role in disease.

The Neutrophil Secretome as a Crucial Link between Inflammation and Thrombosis

“…Neutrophil defensin 1 induces the binding of fibrinogen and thrombospondin-1 to platelets and causes platelet aggregation [96]. Clusterin participates in lipid transport and is considered an adhesion molecule, and thus induces cell aggregates [97]. Zinc-alpha-2-glycoprotein is an adipokine and has been shown to be involved in endothelial dysfunction processes [98][99][100] (Table 1).…”