Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study

Dahlgren, James; Takhar, Harpreet; Anderson-Mahoney, Pamela; Kotlerman, Jenny; Tarr, Jim; Warshaw, Raphael

doi:10.1186/1476-069x-6-8

Cited by 73 publications

(54 citation statements)

References 70 publications

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“…While they may reflect methodological differences, they can also indicate true genetic or environmental influences on disease phenotype. 35 Even though early disease activity was high, the subsequent disease course was characterized by a low mortality rate and a 5-year survival rate that was marginally higher than in the Eurolupus study; 36 this nonetheless suggests that combined diagnostic and therapeutic developments may still have a positive impact on the short-term prognosis in SLE. This improved prognosis occurred despite the fact that the cumulative overall risk for a disease flare in the first 5 years of disease was over 60%.…”

Section: Discussionmentioning

confidence: 95%

Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus

Nossent

Kiss

Rozman³

et al. 2010

Lupus

141

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An inception cohort of patients with systemic lupus erythematosus from 14 European centres was followed for up to 5 years in order to describe the current early disease course. At inclusion patients (n ¼ 200, 89% female, mean age 35 years, 97% Caucasian, mean SLEDAI 12.2) fulfilled a mean of 6.5 ACR classification criteria. The most prevalent criteria were antinuclear Ab presence (97%) followed by anti-dsDNA Ab (74%), arthritis (69%), leukocytopenia (54%) and malar rash (53%), antiphospholipid Ab (48%) and anti-synovial membrane Ab (21.6%). Clinical signs of lupus nephritis (LN) were present in 39% with biopsy-confirmed LN seen in 25%. Frequent additional findings were hypocomplementaemia (54%), anti-SSA Ab (49%), alopecia (26%) and Raynaud's phenomenon (31%). There were few regional differences in disease presentation and management. One and 5-year survival rates were 99% and 97% respectively. During the mean follow-up of 4.1 years 25% entered a state of early disease quiescence by global physician assessment, but the overall risk of subsequent flare was 60%. Maximum SLEDAI scores decreased over time, but 45% of patients accrued damage (SDI !1) for which baseline presence of proteinuria and persistent disease activity were independent predictors. The results indicate minor differences in SLE presentation and treatment within various regions of Europe and a high diagnostic reliance on anti-dsDNA Ab. Despite early reductions in disease activity and improved mortality, the risk for disease flare and damage development is, however, still substantial, especially in patients not entering an early remission. Lupus (2010) 19, 949-956.

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Section: Discussionmentioning

confidence: 95%

Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus

Nossent

Kiss

Rozman³

et al. 2010

Lupus

141

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“…Environmental factors, including chemicals, not only play a role in the development of SLE, but also contribute to increased prevalence of many other ADs [16][17][18][19]. Trichloroethene (TCE), a widely used volatile organic solvent, is a ubiquitous environmental contaminant [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation-derived aldehyde–protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4+ T cells

Wang¹,

König²,

Ansari³

et al. 2008

Free Radical Biology and Medicine

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Lipid peroxidation is implicated in the pathogenesis of various autoimmune diseases. Lipid peroxidation-derived aldehydes (LPDAs) such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE) are highly reactive and bind to proteins, but their role in eliciting an autoimmune response and contribution to disease pathogenesis remains unclear. To investigate the role of lipid peroxidation in the induction and/or exacerbation of autoimmune response, 6-week-old autoimmune-prone female MRL +/+ mice were treated for 4 weeks with trichloroethene (TCE; 10 mmol/kg, i.p., once a week), an environmental contaminant known to induce lipid peroxidation. Sera from TCE-treated mice showed significant levels of antibodies against MDA-and HNE-adducted proteins along with antinuclear antibodies. This suggested that TCE exposure not only caused increased lipid peroxidation, but also accelerated autoimmune responses. Furthermore, stimulation of cultured splenic lymphocytes from both control and TCE-treated mice with MDA-adducted mouse serum albumin (MDA-MSA) or HNE-MSA for 72 h showed significant proliferation of CD4 + T cells in TCE-treated mice as analyzed by flow cytometry. Also, splenic lymphocytes from TCE-treated mice released more IL-2 and IFN-γ into cultures when stimulated with MDA-MSA or HNE-MSA, suggesting a Th1 cell activation. Thus, our data suggest a role for lipid peroxidation-derived aldehydes in TCEmediated autoimmune responses and involvement of Th1 cell activation.

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“…Such occupational exposure is primarily via inhalation and skin exposures. Among men, exposure to any mineral oil was associated with an increased relative risk of developing RA (risk ratio ( In a community comparison study, the population living near an oil field waste site had a significantly higher prevalence of RA and SLE than an unexposed community population (odds ratio OR=10.78 and 19.33, respectively;Dahlgren et al, 2007). The study design, recruitment of participants involved in litigations, limited characterisation of exposures and the impossibility to distinguish the possible effects of mineral oils versus mercury, however, limits the impact of the study.…”

Section: Human Studiesmentioning

confidence: 99%

Scientific Opinion on Mineral Oil Hydrocarbons in Food

2012

EFS2

102

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Consumers are exposed to a range of mineral oil hydrocarbons (MOH) via food. Mineral oil saturated hydrocarbons (MOSH) consist of linear and branched alkanes, and alkyl-substituted cyclo-alkanes, whilst mineral oil aromatic hydrocarbons (MOAH) include mainly alkyl-substituted polyaromatic hydrocarbons. Products, commonly specified according to their physico-chemical properties, may differ in chemical composition depending on the oil source. Technical grade MOH contain 15 -35 % MOAH, which is minimised in food grade MOSH (white oils). Major sources of MOH in food are food packaging and additives, processing aids, and lubricants. Estimated MOSH exposure ranged from 0.03 to 0.3 mg/kg b.w. per day, with higher exposure in children. Specific production practices of bread and grains may provide additional MOSH exposure. Except for white oils, exposure to MOAH is about 20 % of that of MOSH. Absorption of alkanes with carbon number above C 35 is negligible. Branched and cyclic alkanes are less efficiently oxidised than n-alkanes. MOSH from C 16 to C 35 may accumulate and cause microgranulomas in several tissues including lymph nodes, spleen and liver. Hepatic microgranulomas associated with inflammation in Fischer 344 rats were considered the critical effect. The no-observed-adverse-effect level for induction of liver microgranulomas by the most potent MOSH, 19 mg/kg b.w. per day, was used as a Reference Point for calculating margins of exposure (MOEs) for background MOSH exposure. MOEs ranged from 59 to 680. Hence, background exposure to MOSH via food in 1 On request from the European Commission, Question No EFSA-Q-2010-00170, adopted on 3 May 2012. 2 SUMMARYFollowing a request from the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) was asked to deliver a scientific opinion on mineral oil hydrocarbons (MOH) in Food. Mineral oil hydrocarbons occur in food both as a result of contamination and from various intentional uses in food production. In order to assess the need for possible regulatory measures as regards MOH in food, EFSA was requested to assess the risks related to their occurrence in food. More specifically, the opinion should evaluate whether new toxicity data are available and whether the current acceptable daily intakes (ADIs) are still applicable, explore whether certain classes (or subclasses) of MOH are more relevant due to their toxicity or to differences in the way they are metabolised by the human body, and identify the different background sources, other than from adulteration or misuse, of MOH occurrence in food. In addition a dietary exposure assessment was requested for the general population and for specific subgroups of the population (e.g. infants, children and people following specific diets), by taking into account the background occurrence of MOH in food. Included in the request was also to advise on MOH and food classes to be included if monitoring were to be set up for their presence in food.The scientific literature and other sources were s...

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Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study

Abstract: Background: This is a community comparison study that examines persons living in a subdivision exposed to petroleum products and mercury.

Cited by 73 publications

References 70 publications

Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus

Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus

Lipid peroxidation-derived aldehyde–protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4+ T cells

Scientific Opinion on Mineral Oil Hydrocarbons in Food

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