Cluster headache is associated with unhealthy lifestyle and lifestyle-related comorbid diseases: Results from the Danish Cluster Headache Survey

Lund, Nunu; Petersen, Anja Sofie; Snoer, Agneta; Jensen, Rigmor; Barloese, Mads

doi:10.1177/0333102418784751

Cited by 46 publications

(80 citation statements)

References 35 publications

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“…The authors found that CH patients were more often responsible for the head traumas themselves, with more of them being attributed to physical altercations. While our dataset does not allow for a differentiation of mechanism and responsibility, in a previous study, we did find that the studied population consumes more alcohol and is more often active or previous smokers than the controls . Another unavoidable issue is the timing of the trauma in relation to CH onset.…”

Section: Discussionmentioning

confidence: 77%

“…eCH patients had 1.9 ± 3.1 cluster/year (median = 1, [0.75, 2.0]) lasting 8.3 ± 6.4 weeks (median = 7, [4, 12]). Lifestyle and diagnostic factors for these patients have previously been reported …”

Section: Resultsmentioning

confidence: 96%

“…The pattern is the same, however, with THI being more common in patients and a tendency toward THI being more frequent in cCH than eCH . While these studies cannot establish causation, they are hypothesis generating while potential confounders should be kept in mind . A detailed study of mode of THI occurrence was conducted by Lambru et al in a study of 200 CH patients compared with 200 migraine patients .…”

Section: Discussionmentioning

confidence: 99%

“…The remainder has already been published or is in the publication process. This includes sleep and chronobiology, gender differences, lifestyle, diagnostic delay, and assessment of chronorisk …”

Section: Methodsmentioning

confidence: 99%

“…They were matched for sex and age (mean values) and were excluded if they had primary headache more than 1 day/month. The dataset used in this publication is identical to our group’s previous study . The original aim of the Danish Cluster Headache Survey was to detect differences in the presence of sleep disorders between CH patients and controls with an a priori hypothesis that the prevalence was higher in CH patients.…”

Section: Methodsmentioning

confidence: 99%

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Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

et al. 2019

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Objective and Background The diagnostic criteria of episodic and chronic cluster headache (cCH) were recently modified, yet pathophysiological differences between the two are still unclear. The aim of this cross‐sectional study is to identify and characterize other differences between episodic and cCH. Methods Data from a retrospective, questionnaire‐ and interview‐based study were analyzed with a focus on associated factors including traumatic head injury (THI), familial history, and change of phenotype. Attack patterns were analyzed using Gaussian and spectral modeling. Results 400 patients and 200 controls participated. A positive family history was more prevalent in chronic than episodic cluster headache (eCH) (34/146 (23%) vs 33/253 (13%), respectively, P = .008). A history of THI was more common in patients than controls (173/400 (43%) vs 51/200 (26%), respectively, P < .0001) and in chronic compared to eCH (77/146 (53%) vs 96/253 (37%), respectively, P = .004). Patients with a positive family history had a unique diurnal attack pattern with twice the risk of nocturnal attacks as patients who did not report family history. Patients reporting phenotype change had a chronobiological fingerprint similar to the phenotype they had experienced a transition into. A higher attack frequency in chronic patients was the only difference in symptom manifestation across all analyzed subgroups of patients. Conclusions cCH is associated with a positive family history and THI. In familial CH, a peak in nocturnal chronorisk may implicate genes involved in diurnal‐, sleep‐ and homeostatic regulation. The stereotypical nature of the CH attacks themselves is confirmed and differences between subgroups should be sought in other characteristics.

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Section: Discussionmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

et al. 2019

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Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

Harder

Winsvold

Noordam

et al. 2021

Annals of Neurology

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Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro‐Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord‐Trøndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell‐derived RNA‐sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses. Results An association was found with cluster headache for 4 independent loci (r2 < 0.1) with genomewide significance (p < 5 × 10−8), rs11579212 (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.33–1.72 near RP11‐815 M8.1), rs6541998 (OR = 1.53, 95% CI = 1.37–1.74 near MERTK), rs10184573 (OR = 1.43, 95% CI = 1.26–1.61 near AC093590.1), and rs2499799 (OR = 0.62, 95% CI = 0.54–0.73 near UFL1/FHL5), collectively explaining 7.2% of the variance of cluster headache. SNPs rs11579212, rs10184573, and rs976357, as proxy SNP for rs2499799 (r2 = 1.0), replicated in the Norwegian sample (p < 0.05). Gene‐based mapping yielded ASZ1 as possible fifth locus. RNA‐sequencing indicated differential expression of POLR1B and TMEM87B in cluster headache patients. Interpretation This genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders. ANN NEUROL 2021;90:203–216

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Cluster Headache Genomewide Association Study and Meta‐Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor

Winsvold

Harder

Ran

et al. 2023

Annals of Neurology

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ObjectiveThe objective of this study was to aggregate data for the first genomewide association study meta‐analysis of cluster headache, to identify genetic risk variants, and gain biological insights.MethodsA total of 4,777 cases (3,348 men and 1,429 women) with clinically diagnosed cluster headache were recruited from 10 European and 1 East Asian cohorts. We first performed an inverse‐variance genomewide association meta‐analysis of 4,043 cases and 21,729 controls of European ancestry. In a secondary trans‐ancestry meta‐analysis, we included 734 cases and 9,846 controls of East Asian ancestry. Candidate causal genes were prioritized by 5 complementary methods: expression quantitative trait loci, transcriptome‐wide association, fine‐mapping of causal gene sets, genetically driven DNA methylation, and effects on protein structure. Gene set and tissue enrichment analyses, genetic correlation, genetic risk score analysis, and Mendelian randomization were part of the downstream analyses.ResultsThe estimated single nucleotide polymorphism (SNP)‐based heritability of cluster headache was 14.5%. We identified 9 independent signals in 7 genomewide significant loci in the primary meta‐analysis, and one additional locus in the trans‐ethnic meta‐analysis. Five of the loci were previously known. The 20 genes prioritized as potentially causal for cluster headache showed enrichment to artery and brain tissue. Cluster headache was genetically correlated with cigarette smoking, risk‐taking behavior, attention deficit hyperactivity disorder (ADHD), depression, and musculoskeletal pain. Mendelian randomization analysis indicated a causal effect of cigarette smoking intensity on cluster headache. Three of the identified loci were shared with migraine.InterpretationThis first genomewide association study meta‐analysis gives clues to the biological basis of cluster headache and indicates that smoking is a causal risk factor. ANN NEUROL 2023

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Cluster headache is associated with unhealthy lifestyle and lifestyle-related comorbid diseases: Results from the Danish Cluster Headache Survey

Cited by 46 publications

References 35 publications

Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

Cluster Headache Genomewide Association Study and Meta‐Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor

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