Cluster headache and sleep, is there a connection? A review

Barloese, Mads; Jennum, P.; Knudsen, Stine; Jensen, Rigmor Højland

doi:10.1177/0333102412441090

Cited by 35 publications

(34 citation statements)

References 64 publications

(69 reference statements)

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“…Other differences between episodic and chronic patients regarding pain location, side change frequency, autonomic features, and attack duration have been reported as quite minimal . Sleep studies have suggested that the frequent nocturnal attacks may be associated with either REM sleep or the shift between sleep phases in eCH but not in cCH although no major differences exist in sleep architecture …”

Section: Discussionmentioning

confidence: 99%

“…13 Sleep studies have suggested that the frequent nocturnal attacks may be associated with either REM sleep or the shift between sleep phases in eCH but not in cCH although no major differences exist in sleep architecture. [14][15][16] Reported positive family histories in CH range from 2 to 20% 13,[17][18][19] and first-degree relatives have a 5-to 39-fold increased risk of CH. 4,20 We found a positive history in 17% of patients which is within the range of these prior studies.…”

Section: Fig 2-chronorisk Analysis For Familial and Sporadic Clustementioning

confidence: 99%

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Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

et al. 2019

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Objective and Background The diagnostic criteria of episodic and chronic cluster headache (cCH) were recently modified, yet pathophysiological differences between the two are still unclear. The aim of this cross‐sectional study is to identify and characterize other differences between episodic and cCH. Methods Data from a retrospective, questionnaire‐ and interview‐based study were analyzed with a focus on associated factors including traumatic head injury (THI), familial history, and change of phenotype. Attack patterns were analyzed using Gaussian and spectral modeling. Results 400 patients and 200 controls participated. A positive family history was more prevalent in chronic than episodic cluster headache (eCH) (34/146 (23%) vs 33/253 (13%), respectively, P = .008). A history of THI was more common in patients than controls (173/400 (43%) vs 51/200 (26%), respectively, P < .0001) and in chronic compared to eCH (77/146 (53%) vs 96/253 (37%), respectively, P = .004). Patients with a positive family history had a unique diurnal attack pattern with twice the risk of nocturnal attacks as patients who did not report family history. Patients reporting phenotype change had a chronobiological fingerprint similar to the phenotype they had experienced a transition into. A higher attack frequency in chronic patients was the only difference in symptom manifestation across all analyzed subgroups of patients. Conclusions cCH is associated with a positive family history and THI. In familial CH, a peak in nocturnal chronorisk may implicate genes involved in diurnal‐, sleep‐ and homeostatic regulation. The stereotypical nature of the CH attacks themselves is confirmed and differences between subgroups should be sought in other characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Fig 2-chronorisk Analysis For Familial and Sporadic Clustementioning

confidence: 99%

Episodic and Chronic Cluster Headache: Differences in Family History, Traumatic Head Injury, and Chronorisk

et al. 2019

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“…Cluster headaches cause awakening. There is an association with REM sleep in episodic, but not chronic cluster headaches . Hypnic headaches occur in older patients.…”

Section: Expert Opinionmentioning

confidence: 94%

Headache and Sleep

Freedom¹,

Evans²

2013

Headache

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“…Despite an increase in knowledge of the severe pain attacks, the relation to sleep-wake regulation and management, there are numerous unresolved issues in disease pathophysiology and the relation to circadian and intricate sleep-wake associations (6). A genetic link to the hypocretin system (7), a relationship between CH and sleep apnea (8), and a particular temporal relationship with rapid eye movement (REM) sleep (9) have all been suggested.…”

Section: Introductionmentioning

confidence: 99%