Cluster circulating tumor cells in surgical cases of lung cancer

Sawabata, Noriyoshi; Susaki, Yoshiyuki; Nakamura, Takahito; Kawaguchi, Takeshi; Yasukawa, Motoaki; Taniguchi, Shigeki

doi:10.1007/s11748-020-01308-3

Cited by 23 publications

(23 citation statements)

References 15 publications

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“…This is in agreement with the higher expression of metastatic niche modeling genes found in CTC clusters [10]. As CSCs are thought to be the main actors of metastatic dissemination [29], their traveling in CTC clusters might explain the recurrent link between metastatic disease and CTC clusters [10,22,26,30] (Figure 2).…”

Section: Stemnesssupporting

confidence: 85%

“…They might even be counted as multi-numerous CTCs. A few studies, including ours, have reported that the presence of CTC clusters ( ≥ 1 cluster) was pejorative for patient survival for breast, pancreatic, prostate, colon, and lung cancers [30,40,[43][44][45] without signs of metastatic disease at the time of analysis. In connection with these observations, a recent study focused on the prognostic value of in vitro breast and lung cancer CTCs cluster formation [46].…”

Section: Prognostic Valuementioning

confidence: 76%

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Circulating Tumor Cell Clusters: United We Stand Divided We Fall

Amintas

Bedel

Moreau‐Gaudry

et al. 2020

IJMS

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The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer.

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Section: Stemnesssupporting

confidence: 85%

Section: Prognostic Valuementioning

confidence: 76%

Circulating Tumor Cell Clusters: United We Stand Divided We Fall

Amintas

Bedel

Moreau‐Gaudry

et al. 2020

IJMS

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“…Moreover, tight clusters were clearly correlated with poor patient survival [167]. Conversely, in early-stage lung cancer, patients with CTC clusters exhibit significantly lower recurrence-free survival and OS than patients with single CTCs or undetectable CTCs [168].…”

Section: How Ctcs Improve Metastasis Prediction and Diagnosis?mentioning

confidence: 98%

The Role of Circulating Tumor Cells in the Metastatic Cascade: Biology, Technical Challenges, and Clinical Relevance

Dianat‐Moghadam

Azizi

Eslami-S

et al. 2020

Cancers

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Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The assessment of CTCs’ clinical role in early metastasis prediction, diagnosis, and treatment requires more information about their biology, their roles in cancer dormancy, and immune evasion as well as in therapy resistance. Indeed, CTC functional and biochemical phenotypes have been only partially characterized using murine metastasis models and liquid biopsy in human patients. CTC detection, characterization, and enumeration represent a promising tool for tailoring the management of each patient with cancer. The comprehensive understanding of CTCs will provide more opportunities to determine their clinical utility. This review provides much-needed insights into this dynamic field of translational cancer research.

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“…Morphologically, CTCs are of two types: singular CTCs and clustered CTCs. The potential for persistent existence is greater in clustered CTCs, which is a predictor of poor prognosis [ 1 , 2 ]. Clinical biomarkers such as tumor markers and features of radiological diagnosis are surrogate markers for detecting clustered CTCs [ 2 ].…”

mentioning

confidence: 99%

“…The potential for persistent existence is greater in clustered CTCs, which is a predictor of poor prognosis [ 1 , 2 ]. Clinical biomarkers such as tumor markers and features of radiological diagnosis are surrogate markers for detecting clustered CTCs [ 2 ]. It is well known that cancer metastasis often occurs via clustered CTCs [ 3 ], and they have a metastatic nest formation ability that is more than 10 times higher than that of a singular CTC [ 4 ].…”

mentioning

confidence: 99%