Cluster analysis of quantitative parametric maps from DCE-MRI: application in evaluating heterogeneity of tumor response to antiangiogenic treatment

Longo, Dario Livio; Dastrù, Walter; Consolino, Lorena; Espak, Miklos; Arigoni, Maddalena; Cavallo, Federica; Aime, Silvio

doi:10.1016/j.mri.2015.03.005

Cited by 35 publications

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“…The intravascular volume may be neglected as it represents a tiny percentage of the total value 5. Water can cross the barriers between the two compartments, thus contributing to mixing, to some extent, towards the R 1 s of the IN and EX compartments.…”

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Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry

et al. 2018

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It was established through in vivo T1 measurements at low magnetic fields that tumour cells display proton T1 values that are markedly longer than those shown by healthy tissue. Moreover, it has been found that the elongation of T1 parallels the aggressiveness of the investigated tumour. The T1 lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+/K+ ATPase transporters. It follows that the intracellular water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T1 at different magnetic field strengths ranging from 0.2 to 200 mT.

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confidence: 99%

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry

et al. 2018

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“…Angiogenesis is a crucial biological factor involved in tumor growth, progression, and metastatic spread . Newly developed vessels of tumor show immaturity due to an incomplete endothelial wall .…”

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Application of whole‐lesion histogram analysis of pharmacokinetic parameters in dynamic contrast‐enhanced MRI of breast lesions with the CAIPIRINHA‐Dixon‐TWIST‐VIBE technique

et al. 2017

Magnetic Resonance Imaging

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Purpose: To investigate the application of whole-lesion histogram analysis of pharmacokinetic parameters for differentiating malignant from benign breast lesions on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and Methods: In all, 92 women with 97 breast lesions (26 benign and 71 malignant lesions) were enrolled in this study. Patients underwent dynamic breast MRI at 3T using a prototypical CAIPIRINHA-Dixon-TWIST-VIBE (CDT-VIBE) sequence and a subsequent surgery or biopsy. Inflow rate of the agent between plasma and interstitium (K trans ), outflow rate of agent between interstitium and plasma (K ep ), extravascular space volume per unit volume of tissue (v e ) including mean value, 25th/50th/75th/90th percentiles, skewness, and kurtosis were then calculated based on the whole lesion. A single-sample Kolmogorov-Smirnov test, paired t-test, and receiver operating characteristic curve (ROC) analysis were used for statistical analysis. Results: Malignant breast lesions had significantly higher K trans , K ep , and lower v e in mean values, 25th/50th/75th/90th percentiles, and significantly higher skewness of v e than benign breast lesions (all P < 0.05). There was no significant difference in kurtosis values between malignant and benign breast lesions (all P > 0.05). The 90th percentile of K trans , the 90th percentile of K ep , and the 50th percentile of v e showed the greatest areas under the ROC curve (AUC) for each pharmacokinetic parameter derived from DCE-MRI. The 90th percentile of K ep achieved the highest AUC value (0.927) among all histogram-derived values. Conclusion: The whole-lesion histogram analysis of pharmacokinetic parameters can improve the diagnostic accuracy of breast DCE-MRI with the CDT-VIBE technique. The 90th percentile of K ep may be the best indicator in differentiation between malignant and benign breast lesions. Level of Evidence: 4 Technical Efficacy Stage: 2 J. MAGN. RESON. IMAGING 2018;47:91-96. B reast cancer is the most common malignant tumor in women worldwide. [1][2][3] The incidence of breast cancer in young women is increasingly high and has become the leading cause of cancer death in women younger than 40 years. 4,5 Therefore, it is of great importance to detect early and differentiate breast cancer, and to evaluate the therapeutic effect in the ensuing treatment cycle.Angiogenesis is a crucial biological factor involved in tumor growth, progression, and metastatic spread. 6 Newly developed vessels of tumor show immaturity due to an View this article online at wileyonlinelibrary.com.

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“…5) and high pre-treatment baseline tumor vascularity may be predictive of response to these therapies (44, 45). Lastly, novel statistical methods with cluster analysis of quantitative parametric maps derived from DCE-MRI datasets may help predict aggressive histology in renal masses (46) and evaluate heterogeneity in tumor response to anti-angiogenic therapy (47). …”

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confidence: 99%

Quantitative Methods in Abdominal MRI

Madhuranthakam

Yuan²,

Pedrosa

2017

Topics in Magnetic Resonance Imaging

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Recent improvements in arterial spin labeled (ASL) and vastly under-sampled dynamic contrast enhanced (DCE) MRI acquisitions are providing a new opportunity to explore the routine use of quantitative perfusion imaging for evaluation of a variety of abdominal diseases in clinical practice. In this review, we discuss different approaches for the acquisition and data analysis of ASL and DCE MRI techniques for quantification of tissue perfusion and present various clinical applications of these techniques in both neoplastic and non-neoplastic conditions in the abdomen.

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Cluster analysis of quantitative parametric maps from DCE-MRI: application in evaluating heterogeneity of tumor response to antiangiogenic treatment

Cited by 35 publications

References 55 publications

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry

Application of whole‐lesion histogram analysis of pharmacokinetic parameters in dynamic contrast‐enhanced MRI of breast lesions with the CAIPIRINHA‐Dixon‐TWIST‐VIBE technique

Quantitative Methods in Abdominal MRI

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