Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates

Löchner, Christine; Hemmings, Sı̂an M.J.; Kinnear, Craig; Niehaus, Dana J.H.; Nel, Daniel G.; Corfield, Valerie A.; Moolman‐Smook, Johanna C.; Seedat, Soraya; Stein, Dan J.

doi:10.1016/j.comppsych.2004.07.020

Cited by 113 publications

(73 citation statements)

References 47 publications

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“…24,25 The manner in which ICDs and punding are conceptualized has important implications for their pathophysiology and, consequently, their clinical management. 26 Pathophysiology of punding Although a role for dopaminergic stimulation in the development of punding has been confirmed by several lines of evidence, not all patients taking dopaminergic system-enhancing drugs develop this behavior.…”

Section: Methods and Review Criteriamentioning

confidence: 99%

Insights into pathophysiology of punding reveal possible treatment strategies

Fasano

Petrović²

2010

Mol Psychiatry

111

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Punding is a stereotyped behavior characterized by an intense fascination with a complex, excessive, nongoal oriented, repetitive activity. Men tend to repetitively tinker with technical equipment such as radio sets, clocks, watches and car engines, the parts of which may be analyzed, arranged, sorted and cataloged but rarely put back together. Women, in contrast, incessantly sort through their handbags, tidy continuously, brush their hair or polish their nails. Punders are normally aware of the inapposite and obtuse nature of the behavior; however, despite the consequent self-injury, they do not stop such behavior. The most common causes of punding are dopaminergic replacement therapy in patients affected by Parkinson's disease (PD) and cocaine and amphetamine use in addicts. The vast majority of information about punding comes from PD cases. A critical review of these cases shows that almost all afflicted patients (90%) were on treatment with drugs acting mainly on dopamine receptors D1 and D2, whereas only three cases were reported in association with selective D2 and D3 agonists. Epidemiological considerations and available data from animal models suggest that punding, drug-induced stereotypies, addiction and dyskinesias all share a common pathophysiological process. Punding may be related to plastic changes in the ventral and dorsal striatal structures, including the nucleus accumbens, and linked to psychomotor stimulation and reward mechanisms. Possible management guidelines are proposed.

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Section: Methods and Review Criteriamentioning

confidence: 99%

Insights into pathophysiology of punding reveal possible treatment strategies

Fasano

Petrović²

2010

Mol Psychiatry

111

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“…İsrail de cinsel istismar ve OKB arasındaki ilişkinin araştırıldığı bir çalışmada, OKB tanısı almış 30 hastanın %53.3' ünde çocukluk çağı cinsel istismar yaşantılarına rastlandığı aktarılmıştır (Caspi et al, 2008). Lochner ve arkadaşlarının yaptıkları bir çalışmada, dürtüsellik ile duygusal istismar arasında bir ilişki olduğu belirtilmiştir (Lochner et al, 2005). Lockwood ve arkadaşlarının yeme bozukluğu olan hastalarla yaptıkları bir çalışmada, hastalarda bulunan kompulsif belirtilerde çocukluk çağı travmaların rolü araştırılmış ve temizlik kompulsiyonlarının cinsel istismarla aralarında anlamlı bir ilişki saptanmıştır (Lockwood et al, 2004).…”

Section: Discussionunclassified

Childhood Mental Trauma in Adult Obsessive Compulsive Disorder Patients

Kıvılcım¹,

Erensoy²

2017

JNBS

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“…Several evidences of dopamine dysregulation in OCD have also been found in humans. An indirect strong evidence of the role of dopamine in OCD is provided by some neurological diseases associated with dopaminergic dysfunction such as Tourette's syndrome, Sydenham's chorea and Parkinson disease, which often show obsessive-compulsive symptoms in their clinical presentation (Lochner et al, 2005;Pauls et al, 1986Pauls et al, , 1995; in addition, Tourette's Syndrome and OCD are supposed to share common neurobiological underpinnings and genetic factors, due to the fact that they are described as comorbid, mainly in the childhood-onset forms (Perani et al 2008). Moreover, the increase in synaptic dopamine levels due to the effect of drugs such as cocaine and amphetamines h a v e b e e n r e p o r t e d t o e x a c e r b a t e o r i n d u c e a s w e l l a s t o i m p r o v e O C D s y m p t o m s (Westemberg et al 2007).…”

Section: Dopaminergic Agentsmentioning

confidence: 99%