Abstract:magnetic resonance imaging (mfMRI) is frequently used to determine spatial patterns of muscle involvement in exercising humans. A frequent finding in mfMRI is that, even within synergistic muscle groups, signal intensity (SI) data from individual voxels can be quite heterogeneous. The purpose of this study was to develop a novel method for organizing heterogeneous mfMRI data into clusters whose members behave similarly to each other but distinctly from members of other clusters and apply it in studies of funct… Show more
“…Qualitatively, this finding is similar to that of Akima et al [19] in their study of intermittent isotonic dorsiflexion exercise and to that of our previous study of sustained isometric dorsiflexion at 40% MVC [18]. Moreover, this study demonstrates that this spatial heterogeneity is exercise intensity dependent, because it exists during contractions at 60% of MVC but not during contractions at 30% of MVC.…”
Section: Discussionsupporting
confidence: 92%
“…Moreover, this study demonstrates that this spatial heterogeneity is exercise intensity dependent, because it exists during contractions at 60% of MVC but not during contractions at 30% of MVC. Finally, the findings confirm those of our previous study, in which we observed heterogeneity in the mfMRI SI time course during exercise but not following exercise [18].…”
Section: Discussionsupporting
confidence: 91%
“…While postexercise T 2 -weighted SI changes are useful as a noninvasive indication of the spatial pattern of muscle activation during a previous bout of exercise, it has also been shown that postexercise T 2 -weighted SI changes may not fully capture the spatially heterogeneous functional properties of exercising muscles [18]. For such applications, it may be necessary to examine the time course of SI changes, obtained during the exercise bout itself [18,19].…”
Section: Introductionmentioning
confidence: 99%
“…While postexercise T 2 -weighted SI changes are useful as a noninvasive indication of the spatial pattern of muscle activation during a previous bout of exercise, it has also been shown that postexercise T 2 -weighted SI changes may not fully capture the spatially heterogeneous functional properties of exercising muscles [18]. For such applications, it may be necessary to examine the time course of SI changes, obtained during the exercise bout itself [18,19]. For instance, regional variations in the mfMRI SI time course obtained during sustained isometric dorsiflexion exercise at 40% of MVC have been observed in the anterior compartment muscles that may reflect heterogeneity in the metabolic, hemodynamic and/or mechanical responses to neural activation [18].…”
Section: Introductionmentioning
confidence: 99%
“…For such applications, it may be necessary to examine the time course of SI changes, obtained during the exercise bout itself [18,19]. For instance, regional variations in the mfMRI SI time course obtained during sustained isometric dorsiflexion exercise at 40% of MVC have been observed in the anterior compartment muscles that may reflect heterogeneity in the metabolic, hemodynamic and/or mechanical responses to neural activation [18].…”
It has previously been observed that during isometric dorsiflexion exercise, the time course of T2-weighted signal intensity (SI) changes is spatially heterogeneous. The purpose of this study was to test the hypothesis that this spatial heterogeneity would increase at higher contraction intensities. Eight subjects performed 90-s isometric dorsiflexion contractions at 30% and 60% of maximum voluntary contraction (MVC) while T2-weighted (repetition time/echo time=4000/35 ms) images were acquired. SI was measured before, during and after the contractions in regions of interest (ROIs) in the extensor digitorum longus (EDL) muscle and the deep and superficial compartments of the tibialis anterior (D-TA and S-TA, respectively). For all ROIs at 30% MVC, SI changes were similar. The maximum postcontraction SI was greater than the SI during exercise. At 60% MVC, SI changes during contraction were greater in the S-TA than in the D-TA and EDL. For the EDL and D-TA, the maximum postcontraction SI was greater than those during exercise. For the S-TA, the maximum postcontraction change was greater than the changes at t=8, 20 and 56 s but not the end-exercise value. We conclude that spatial heterogeneity increases during more intense dorsiflexion contractions, possibly reflecting regional differences in perfusion or neural activation of the muscle.
“…Qualitatively, this finding is similar to that of Akima et al [19] in their study of intermittent isotonic dorsiflexion exercise and to that of our previous study of sustained isometric dorsiflexion at 40% MVC [18]. Moreover, this study demonstrates that this spatial heterogeneity is exercise intensity dependent, because it exists during contractions at 60% of MVC but not during contractions at 30% of MVC.…”
Section: Discussionsupporting
confidence: 92%
“…Moreover, this study demonstrates that this spatial heterogeneity is exercise intensity dependent, because it exists during contractions at 60% of MVC but not during contractions at 30% of MVC. Finally, the findings confirm those of our previous study, in which we observed heterogeneity in the mfMRI SI time course during exercise but not following exercise [18].…”
Section: Discussionsupporting
confidence: 91%
“…While postexercise T 2 -weighted SI changes are useful as a noninvasive indication of the spatial pattern of muscle activation during a previous bout of exercise, it has also been shown that postexercise T 2 -weighted SI changes may not fully capture the spatially heterogeneous functional properties of exercising muscles [18]. For such applications, it may be necessary to examine the time course of SI changes, obtained during the exercise bout itself [18,19].…”
Section: Introductionmentioning
confidence: 99%
“…While postexercise T 2 -weighted SI changes are useful as a noninvasive indication of the spatial pattern of muscle activation during a previous bout of exercise, it has also been shown that postexercise T 2 -weighted SI changes may not fully capture the spatially heterogeneous functional properties of exercising muscles [18]. For such applications, it may be necessary to examine the time course of SI changes, obtained during the exercise bout itself [18,19]. For instance, regional variations in the mfMRI SI time course obtained during sustained isometric dorsiflexion exercise at 40% of MVC have been observed in the anterior compartment muscles that may reflect heterogeneity in the metabolic, hemodynamic and/or mechanical responses to neural activation [18].…”
Section: Introductionmentioning
confidence: 99%
“…For such applications, it may be necessary to examine the time course of SI changes, obtained during the exercise bout itself [18,19]. For instance, regional variations in the mfMRI SI time course obtained during sustained isometric dorsiflexion exercise at 40% of MVC have been observed in the anterior compartment muscles that may reflect heterogeneity in the metabolic, hemodynamic and/or mechanical responses to neural activation [18].…”
It has previously been observed that during isometric dorsiflexion exercise, the time course of T2-weighted signal intensity (SI) changes is spatially heterogeneous. The purpose of this study was to test the hypothesis that this spatial heterogeneity would increase at higher contraction intensities. Eight subjects performed 90-s isometric dorsiflexion contractions at 30% and 60% of maximum voluntary contraction (MVC) while T2-weighted (repetition time/echo time=4000/35 ms) images were acquired. SI was measured before, during and after the contractions in regions of interest (ROIs) in the extensor digitorum longus (EDL) muscle and the deep and superficial compartments of the tibialis anterior (D-TA and S-TA, respectively). For all ROIs at 30% MVC, SI changes were similar. The maximum postcontraction SI was greater than the SI during exercise. At 60% MVC, SI changes during contraction were greater in the S-TA than in the D-TA and EDL. For the EDL and D-TA, the maximum postcontraction SI was greater than those during exercise. For the S-TA, the maximum postcontraction change was greater than the changes at t=8, 20 and 56 s but not the end-exercise value. We conclude that spatial heterogeneity increases during more intense dorsiflexion contractions, possibly reflecting regional differences in perfusion or neural activation of the muscle.
A restricted field of view (rFOV) approach for imaging a dynamic time series of volumes of limited spatial extent within a larger subject is described. The shorter readout with rFOV-MRI can be exploited to either limit image artifacts or increase spatial resolution. To accomplish rFOV imaging of a multislice volume for a dynamic series, an outer volume suppression (OVS) preparation that saturates signal external to a cylinder through the subject is followed by slice-selective excitation and a spiral readout. The pass-and stopband efficiencies of the OVS in an agar gel phantom were 97% (؎1.5%) and 3% (؎1%), respectively. Profiles of the temporal signal-to-noise ratio (SNR) were measured in a phantom and an adult brain. The rFOV sequence reduced distortions from off-resonance signal and T* 2 -induced blurring compared to a conventional sequence. Sequence utility is demonstrated for high-resolution rFOV functional MRI ( Key words: selective excitation; outer volume suppression; rFOV spiral imaging; distortion reduction; dynamic time series; fetal MRI; fMRI A dynamic time series of images can be used to measure exogenous contrast uptake (e.g., in perfusion-weighted imaging (PWI)) to study cerebral, renal, and myocardial function (1,2), or to assess endogenous contrast mechanisms (e.g., blood oxygen level-dependent (BOLD) contrast) as a measure of muscular (3,4) or neuronal (5) activity. It is not straightforward to restrict the field of view (FOV), i.e., to image volumes with limited spatial extent within a larger subject (6,7) for MRI of a dynamic time series, due to inevitable imperfections in static and radiofrequency (RF) magnetic field homogeneity in such subjects. When function is detected in signal fluctuations of a few percent, aliasing of signal from outside a restricted FOV (rFOV) is especially problematic.rFOV-MRI can help to maintain a short readout length and therefore control image distortions for a large subject, or, if one can accept some degree of image distortion, rFOV-MRI can provide morphologic and functional details at resolutions that would be inaccessible with conventional rapid imaging schemes.The advantages of a short readout duration have been described elsewhere (8 -10). They include reduced sensitivity to artifacts arising from off-resonance signal and motion, at the expense of SNR. The advantage of a reduced readout time has also been quantified in terms of reduced side-lobe amplitudes of the point-spread function (PSF) (8). Controlling the level of distortion via rFOV-MRI is comparable to distortion reduction utilizing sensitivity encoding (SENSE) (9), but without the requisite of conducting complex unaliasing operations using coil sensitivity information. Nevertheless, parallel imaging or interleaved spiral trajectories (8 -10) can additionally be employed for further improvement of image quality.For rFOV-MRI with Cartesian sampling schemes, while the anti-aliasing filter (11) prevents aliasing along the frequency direction, it is more difficult to prevent aliasing along the phase-enco...
Exercise-induced changes of transverse proton relaxation time (T2 ), tissue perfusion and metabolic turnover were investigated in the lower back muscles of volunteers by applying muscle functional MRI (mfMRI) and diffusion-weighted imaging (DWI) before and after as well as dynamic (31) P-MRS during the exercise. Inner (M. multifidus, MF) and outer lower back muscles (M. erector spinae, ES) were examined in 14 healthy young men performing a sustained isometric trunk-extension. Significant phosphocreatine (PCr) depletions ranging from 30% (ES) to 34% (MF) and Pi accumulations between 95% (left ES) and 120%-140% (MF muscles and right ES) were observed during the exercise, which were accompanied by significantly decreased pH values in all muscles (∆pH ≈ -0.05). Baseline T2 values were similar across all investigated muscles (approximately 27 ms at 3 T), but revealed right-left asymmetric increases (T2 ,inc ) after the exercise (right ES/MF: T2 ,inc = 11.8/9.7%; left ES/MF: T2 ,inc = 4.6/8.9%). Analyzed muscles also showed load-induced increases in molecular diffusion D (p = .007) and perfusion fraction f (p = .002). The latter parameter was significantly higher in the MF than in the ES muscles both at rest and post exercise. Changes in PCr (p = .03), diffusion (p < .01) and perfusion (p = .03) were strongly associated with T2,inc , and linear mixed model analysis revealed that changes in PCr and perfusion both affect T2,inc (p < .001). These findings support previous assumptions that T2 changes are not only an intra-cellular phenomenon resulting from metabolic stress but are also affected by increased perfusion in loaded muscles.
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