Cluster analysis of HZE particle tracks as applied to space radiobiology problems

Batmunkh, Munkhbaatar; Bayarchimeg, Lkhagvaa; Lkhagva, O.; Belov, Oleg

doi:10.1134/s1547477114010075

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…While this approach is interesting for immediate applications (see e.g. [49]), it currently does not take into account the mechanistic simulation of physico-chemical and chemical interactions with sensitive biological targets, which may be required for detailed simulations of damage induction.…”

Section: Clustering Algorithmsmentioning

confidence: 99%

Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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Section: Clustering Algorithmsmentioning

confidence: 99%

Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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“…To address the possibility of DNA damage, we also performed the cluster analysis of track structures of emitted particles at nanometer scale. For this purpose we used the cluster analyzing algorithm developed earlier (Batmunkh et al, 2013). The diameter of all produced clusters was set to be 2 nm that corresponds to the diameter of the native double-stranded DNA.…”

Section: A) B)mentioning

confidence: 99%

Simulations of Radioactive Decays: an Application of Low-Energy Electromagnetic Packages for the Nuclear Medicine

2015

Mong. J. Biol. Sci.

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Cite this paper as:Problems of the radiobiology and the nuclear medicine require clarifying the specifi cs of radionuclides interactions with unhealthy cells. In this work we aimed to simulate emitting particles tracks of radionuclides and their radioactive decays at DNA level inside the cell nucleus. Accordingly, using the Monte Carlo-based track structure simulation technique, we estimated the radial distribution of deposited energy and kinetic energy spectra of electrons produced by primary particles resulting from radioactive decays of diff erent radionuclides within cell nucleus. To address the possibility of DNA damage, we performed the cluster analysis of track structures of emitted particles inside the volumes corresponding to the size of the native double-stranded DNA. For this purpose, G4-RadioactiveDecay and lowenergy electromagnetic packages form Geant4 Monte-Carlo toolkit were combined together. Besides, a comparative analysis was performed for various low-energy electromagnetic packages as G4-DNA and G4-Livermore. Batmunkh, M., Belov, O. V., Lhagva, O., Bayarchimeg, L., Minjmaa, L. & Battogtokh, P. 2015. Simulations of radioactive decays: an application of low-energy electromagnetic packages for the nuclear medicine. Mong. J. Biol. Sci.,: 55-64.

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Cluster analysis of HZE particle tracks as applied to space radiobiology problems

Cited by 2 publications

References 7 publications

Review of Geant4-DNA applications for micro and nanoscale simulations

Review of Geant4-DNA applications for micro and nanoscale simulations

Simulations of Radioactive Decays: an Application of Low-Energy Electromagnetic Packages for the Nuclear Medicine

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