Cluster Analysis of Chronic Rhinosinusitis Suggests Gender-Based Differences

Jurlin, Lana; Gregurić, Tomislav; Baudoin, Tomislav; Grgić, Marko; Pažanin, Leo; Scadding, Glenis K.; Kalogjera, Livije

doi:10.1159/000492966

Cited by 7 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recently published cluster analysis evaluating QoL of CRS patients displayed three groups with similar symptoms. One cluster comprised women with CRSsNP, another cluster grouped men with CRSwNP and the third cluster represented women and men diagnosed with CRSwNP [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a cluster analysis of SNOT-22 and VAS values regarding CRSwNP and CRSsNP patients according to gender was performed. Three clusters were identified: the first cluster comprised 37 female patients with CRS without nasal polyps (CRSsNP), the second cluster comprised 30 patients with CRS and NP (CRSwNP; 15 males and 15 females); and the third cluster had 30 male patients with CRS without NP (CRSsNP), indicating similarities in men and women diagnosed with CRSwNP but not CRSsNP patients [ 12 ]. With regards to sex as a factor influencing PROMs, higher SNOT-22 scores in patients suffering from CRS (with and without polyps) presenting for sinus surgery have been reported in women [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differences in men and women suffering from CRSwNP and AERD in quality of life

Bartosik

Liu

Campion

et al. 2020

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Purpose While the overall impact of chronic rhinosinusitis (CRS) on patients’ health is diverse, many affected individuals have a substantially impaired quality of life (QoL). The aim of this study was to evaluate the impact of sex-associated differences specifically in the subgroups of CRS with nasal polyps (CRSwNP) and aspirin-exacerbated respiratory disease (AERD) by assessing QoL parameters in women and men separately. Methods In a retrospective single-center study, 59 patients with CRSwNP (39 males and 20 females) and 46 patients with AERD (18 males and 28 females) were included. Patient-reported outcome measures (PROM) evaluating QoL via the Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) as well as the total polyp score (TPS) were analysed. Results There was no significant difference in TPS (p = 0.5550) and total SNOT-20 GAV scores (p = 0.0726) between male or female patients with CRSwNP or AERD. Furthermore, no significant sex differences were found within disease groups regarding the subcategories of the SNOT-20 GAV items. Conclusion Thus, quality of life is severely impaired in patients suffering from various forms of CRS regardless of their sex.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differences in men and women suffering from CRSwNP and AERD in quality of life

Bartosik

Liu

Campion

et al. 2020

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…27,28 According to Jurlin et al (n = 97), postsurgical outcomes, like baseline symptoms, appeared to vary between genders by disease subtype, with men with CRSsNP having significantly greater subjective improvement than women with CRSsNP. 20 Busaba et al (n = 514) seems to corroborate this finding, with women with CRSsNP having greater rates of revision surgery than men. 18 The Jurlin group found no subjective gender differences in the postsurgical CRSwNP group 20 in contrast with Brescia et al (n = 172), who studied nasal polyp recurrences in patients with CRSwNP and found that young adult males had higher recurrence rates than young adult females.…”

Section: Gender Differences In Pathophysiology (Table 2)mentioning

confidence: 84%

“…17,18 This finding has been generally accepted in the literature. 19 When controlling for CRS endotype, 2 studies did not find any gender differences in subjective disease burden in those suffering from CRSwNP, 11,20 though Jurlin et al (n = 97) did reveal gender differences in those with CRSsNP. 20 This finding is disputed however by Lal et al (n = 272), who found that women with CRSwNP still had higher SNOT-22 scores than men despite similar computed tomography findings.…”

Section: Discussionmentioning

confidence: 97%

Gender Differences in Adults With Chronic Rhinosinusitis: A Scoping Review

Behnke,

Dundervill,

Al‐Asadi

et al. 2024

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

ObjectiveGender differences in chronic rhinosinusitis (CRS) have been demonstrated in many studies over the last 15 years. The purpose of this scoping review is to investigate the current knowledge on gender differences in CRS and to analyze the gaps in the literature.Data SourcesA systematic search of PubMed, Cochrane Library, and Embase databases was performed.Review MethodsThis scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐analyses Extension for Scoping Reviews (PRISMA‐ScR) guidelines. Studies that evaluated gender differences in CRS were included in the review.ResultsOf the 523 abstracts reviewed, a total of 23 studies met the criteria for inclusion. Articles consisted of retrospective and prospective cohort studies. They were divided into 3 categories based on whether they evaluated gender differences in (1) presentation and baseline quality of life, (2) pathophysiology, and/or (3) outcomes of treatment. Eleven studies addressed differences in presentation, 5 addressed differences in pathophysiology, and 10 dealt with differences in outcomes after surgical or medical management. Most of the studies showed worse baseline QoL secondary to CRS in women, with outcome of treatment being similar in both genders.ConclusionThe experience of CRS appears to vary between genders, with women experiencing a greater subjective burden of disease than men, though with similar outcomes after treatment. Further research is indicated, particularly involving the pathophysiology of CRS, to fully understand the underlying causes of these discrepancies.

show abstract

“…A large number of studies have attempted to identify patient variables that drive CRS patterns and response to treatment ( Jurlin et al., 2019 ; Morse et al., 2019 ; De Filippo et al., 2021 ; Soler et al., 2021 ). However, limited evidence suggests that advanced age can result in a unique CRS pathophysiology and potentially influences response to medical therapy.…”

Section: Discussionmentioning

confidence: 99%

Age-Associated Changes of Nasal Bacterial Microbiome in Patients With Chronic Rhinosinusitis

Chen

Gao

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Age-related changes in nasal bacterial microbiota of patients with chronic rhinosinusitis (CRS) remains unclear. In this study, we aimed to identify distinct characteristics of nasal bacterial microbiota between aged and younger patients with CRS through 16S rDNA gene sequencing. Patients with CRS undergoing endoscopic sinus surgery were recruited and separated into aged (≥60 years, median age = 66 years, N = 17) and younger (<60 years, median age = 35.5 years, N = 14) patients. Diversity, bacterial composition and metabolic activities of nasal microbiota between aged and younger patients were compared. Results have shown that levels of OTUs (p = 0.0173) and microbiota diversity (all p < 0.05) decreased significantly in aged patients. The abundance of phylum Actinobacteria, and genus Corynebacterium were significantly higher in aged patients, while the abundance of phylum Bacteroidetes, Fusobacteria, and genus Fusobacterium, Peptoniphilus were significantly higher in younger patients. In addition, predicted functional profiles have revealed that 41 KEGG pathways involving in 12 metabolic pathways, 4 genetic information processing, 3 environmental information processing, 4 cellular processes, 8 organismal systems, 6 human diseases, and 4 unclassified pathways were identified. Among which, the vast majority of metabolic activities are involved in replication and repair, membrane transport, translation, and the metabolism of amino acid, carbohydrate, energy, cofactors and vitamins, and nucleotide. On the level of the thirdly bacterial metabolic pathways, purine metabolism, glycine, serine and threonine metabolism, valine, leucine and isoleucine biosynthesis, glycolysis/gluconeogenesis and phenylalanine, tyrosine and tryptophan biosynthesis are significantly up-regulated while carbon fixation pathways in prokaryotesand methane metabolism are significantly down-regulated in aged patients. Overall, our analysis revealed that age-related physiological and pathological changes on the nasal mucosal surface may alter the host immune response and be highly associated with the nasal bacterial microbiota of patients with CRS. However, future studies are needed to elucidate the causal relationship.

show abstract

Cluster Analysis of Chronic Rhinosinusitis Suggests Gender-Based Differences

Cited by 7 publications

References 21 publications

Differences in men and women suffering from CRSwNP and AERD in quality of life

Differences in men and women suffering from CRSwNP and AERD in quality of life

Gender Differences in Adults With Chronic Rhinosinusitis: A Scoping Review

Age-Associated Changes of Nasal Bacterial Microbiome in Patients With Chronic Rhinosinusitis

Contact Info

Product

Resources

About