Clubbing in Hypersensitivity Pneumonitis

Sansores, Raúl H; Salas, Jorge; Chapela, Rocío; Barquín, Nora; Selman, Moisés

doi:10.1001/archinte.1990.00390200053010

Cited by 49 publications

(2 citation statements)

References 12 publications

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“…Depending on the causative antigen, some studies suggested that bird-fancier’s hypersensitivity pneumonitis might have a worse prognosis than farmer’s lung, probably because patients with fibrosis on HRCT and/or lung biopsy have a poorer prognosis [44]. Factors associated with worse prognosis include an exposure for a longer period [45], older age, a histologic pattern of either fibrotic NSIP or UIP [46], digital clubbing [47], and a greater intensity of exposure [3]. …”

Section: Prognosismentioning

confidence: 99%

Hypersensitivity pneumonitis: a complex lung disease

Sforza

Marinou

2017

Clin Mol Allergy

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Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitium, due to a delayed allergic reaction. Such reaction is secondary to a repeated and prolonged inhalation of different types of organic dusts or other substances to which the patient is sensitized and hyper responsive, primarily consisting of organic dusts of animal or vegetable origin, more rarely from chemicals. The prevalence of HP is difficult to evaluate because of uncertainties in detection and misdiagnosis and lacking of widely accepted diagnostic criteria, and varies considerably depending on disease definition, diagnostic methods, exposure modalities, geographical conditions, agricultural and industrial practices, and host risk factors. HP can be caused by multiple agents that are present in work places and in the home, such as microbes, animal and plant proteins, organic and inorganic chemicals. The number of environment, settings and causative agents is increasing over time. From the clinical point of view HP can be divided in acute/subacute and chronic, depending on the intensity and frequency of exposure to causative antigens. The mainstay in managing HP is the avoidance of the causative antigen, though the complete removal is not always possible due to the difficulties to identify the agent or because its avoidance may lead to major changes in life style or occupational settings. HP is a complex syndrome that needs urgently for more stringent and selective diagnostic criteria and validation, including wider panels of IgG, and a closer collaboration with occupational physicians, as part of a multidisciplinary expertise.

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Section: Prognosismentioning

confidence: 99%

Hypersensitivity pneumonitis: a complex lung disease

Sforza

Marinou

2017

Clin Mol Allergy

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“…Clubbing may be present and usually represents a poorer prognosis. [26] Chronic respiratory failure occurs in severe cases leading to cor pulmonale. In chronic HP, precipitating antibodies or specific IgG may be negative if there is time latency between exposure and presentation.…”

Section: Chronic Hpmentioning

confidence: 99%

Hypersensitivity pneumonitis

Khalfey¹

2015

S Afr Res J

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<p>Hypersensitivity pneumonitis (HP) refers to the inflammatory lung condition that arises from inhalational exposure to various (mostly organic) antigens with the development of lymphocytic alveolitis and granulomatous pneumonitis. A myriad of antigens have been implicated and the list continues to grow. The clinical features are varied, implicated antigens protean, and the investigations complementary in making a diagnosis, but the condition remains a difficult one to diagnose, mostly due to a lack of clinical suspicion. In this article we discuss HP, its aetiology, clinical features as well as diagnosis and management.</p>

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