Clozapine producing weight loss

Nicolaï, Thomas; Ravan, JR; Jebaraj, Paul; Braganza, Deepa

doi:10.4103/0022-3859.58947

Cited by 7 publications

(7 citation statements)

References 9 publications

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“…In the past, weight loss associated with clozapine use has been attributed to improved mental state, better adverse-effect management and engagement in dietary practices and regular exercise (5). However, there is literature reporting weight loss early during clozapine treatment, associated with poor response to treatment (6). In contrast, the patients who lost weight in this case report had responded well clinically to clozapine and their positive symptoms had reduced markedly with treatment.…”

Section: Discussioncontrasting

confidence: 61%

Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy

et al. 2020

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Section: Discussioncontrasting

confidence: 61%

Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy

et al. 2020

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“…The authors proposed that there might be some underlying genetic cause to the observed changes. Thomas and colleagues however, noted that weight loss early on following clozapine use was associated with a poor response to treatment [Thomas et al 2009]. JX's response to clozapine follows the pattern observed by Thomas and colleagues [Thomas et al 2009].…”

Section: Discussionmentioning

confidence: 76%

“…The case of JX and the observation by Thomas and colleagues suggests that for some patients with TRS, weight loss following clozapine use indicates poor response to treatment [Thomas et al 2009]. It is of interest to note that a number of studies in the past have associated weight gain and a good response to clozapine [Stanton, 1995; Czobor et al 2002].…”

Section: Discussionmentioning

confidence: 99%

Significant weight loss following clozapine use, how is it possible? A case report and review of published cases and literature relevant to the subject

Tungaraza¹

2016

Therapeutic Advances in Psychopharmacology

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It has been repeatedly shown that clozapine is more efficacious than other antipsychotics in the management of treatment-resistant schizophrenia. However, clozapine is associated with a number of side effects including weight gain. Antipsychotic-induced weight gain has been linked with a number of untoward events including psychological factors such as stigma and low self-esteem, and physical factors such as metabolic syndromes and untimely death. The mechanism underlying antipsychotic (including clozapine)-induced weight gain is not clearly understood, although it is said to involve several brain areas, several neurotransmitters, neuropeptides and genetic factors. To some individuals however, clozapine use is associated with significant weight loss (13.5-50% of body weight). The observed weight loss in these groups of patients has not been attributed to any underlying diagnosable physical disorders. There have been a handful cases published with this phenomenon, which seems to be contrary to what is expected when clozapine is prescribed. From the currently published cases three groups emerge - those who lost weight simply by taking clozapine, those who lost weight due to improved mental state, engaging in diet and increased exercise, and those for whom weight loss was a sign of a poor response to clozapine. A case of JX who has a diagnosis of schizoaffective disorder is presented. JX lost over 26% of her body weight when she was prescribed clozapine. A detailed review of other published cases is undertaken. The underlying mechanisms involving weight loss are discussed and the implications to clinicians are highlighted. Coordinated studies to examine these groups of patients may provide some insight, not only in the mechanism of clozapine-induced weight loss, but also in the better management of patients with treatment-resistant schizophrenia involving clozapine use.

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“…A further case series reported weight loss in five patients who failed to respond to clozapine treatment. They described a range of weight loss from 4 kg to 13 kg and hypothesised that early weight loss may be an indicator of a poor clinical response to clozapine in treatment resistant schizophrenia 12. It has been reported that up to 10% of patients on clozapine will develop obsessive-compulsive symptoms 13.…”

Section: Discussionmentioning

confidence: 99%

Dramatic weight loss associated with commencing clozapine

Lally

McDonald²

2011

Case Reports

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The authors report the case of a 44-year-old man with a long history of chronic enduring schizophrenia who experienced dramatic weight loss after commencing treatment with clozapine, an antipsychotic medication characteristically associated with the greatest degree of weight gain among medical treatments for schizophrenia. He was obese with a body mass index (BMI) of 41.5 kg/m(2), but after commencing clozapine therapy he experienced an improvement in psychotic symptoms and 40% loss of his body weight attained through an altered diet and exercise regime, which resulted in him attaining a normal BMI of 24.8 kg/m(2).

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Clozapine producing weight loss

Cited by 7 publications

References 9 publications

Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy

Clozapine induced severe weight loss in resistant schizophrenia managed with risperidone add-on therapy

Significant weight loss following clozapine use, how is it possible? A case report and review of published cases and literature relevant to the subject

Dramatic weight loss associated with commencing clozapine

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