Clozapine-induced Weight Loss and Stuttering in a Patient with Schizophrenia

Das, Soumitra; Manjunatha, N; Thirthali, Jagadisha

doi:10.4103/ijpsym.ijpsym_523_17

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Moreover, in three (3.5%) episodes, the stuttering spontaneously remitted despite continuation of the offending drug with no dose reduction[ 16 - 18 ]. However, three (3.5%) episodes did not respond to the dose reduction[ 19 - 21 ]. For four (4.6%) episodes, the authors did not describe the actions taken to manage stuttering[ 22 - 25 ].…”

Section: Managementmentioning

confidence: 99%

Drug-induced stuttering: A comprehensive literature review

Nikvarz

Sabouri

2022

WJP

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Drug-induced stuttering (DIS) is a type of neurogenic stuttering (NS). Although DIS has not been reported as frequently as other cases of NS in the literature, it is not a negligible adverse drug reaction (ADR) which can significantly affect the quality of life if not treated. This literature review aims to evaluate the epidemiological and clinical characteristics of DIS and suggests some pathophysiological mechanisms for this ADR. Relevant English-language reports in Google Scholar, PubMed, Web of Science, and Scopus were identified and assessed without time restriction. Finally, a total of 62 reports were included. Twenty-seven drugs caused 86 episodes of stuttering in 82 cases. The most episodes of DIS were related to antipsychotic drugs (57%), mostly including clozapine, followed by central nervous system agents (11.6%) and anticonvulsant drugs (9.3%). The majority of the cases were male and between the ages of 31 and 40 years. Repetitions were the most frequent core manifestations of DIS. In 55.8% of the episodes of DIS, the offending drug was withdrawn to manage stuttering, which resulted in significant improvement or complete relief of stuttering in all cases. Based on the suggested pathophysiological mechanisms for developmental stuttering and neurotransmitters dysfunctions involved in speech dysfluency, it seems that the abnormalities of several neurotransmitters, especially dopamine and glutamate, in different circuits and areas of the brain, including cortico-basal ganglia-thalamocortical loop and white matter fiber tracts, may be engaged in the pathogenesis of DIS.

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Section: Managementmentioning

confidence: 99%

Drug-induced stuttering: A comprehensive literature review

Nikvarz

Sabouri

2022

WJP

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Schizophrenia and Related Psychoses

2021

The Maudsley Prescribing Guidelines in Psychiatry

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Despite disagreements about nomenclature, patients who develop schizophrenic or schizophrenialike symptoms in later life are often seen in clinical practice. Questions about the etiology of late-life psychotic disorders and about their similarities or differences from early-onset disorders remain unanswered. Neuroimaging techniques have been used to study patients with late onset of psychosis, and in substantial subgroups of patients (from 25% to 100% in various studies) compared with agematched control subjects, structural and functional abnormalities have been found. We review the literature on imaging in late-life schizophrenia and related psychotic disorders, and we present data from our own investigations of patients with these disorders. We discuss the potential usefulness of imaging evaluations in patients with late-onset disorders, and we offer suggestions for future investigations.

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Clozapine research from India: A systematic review

Grover

Kathiravan

2023

Asian Journal of Psychiatry

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Clozapine-induced Weight Loss and Stuttering in a Patient with Schizophrenia

Cited by 4 publications

References 10 publications

Drug-induced stuttering: A comprehensive literature review

Drug-induced stuttering: A comprehensive literature review

Schizophrenia and Related Psychoses

Clozapine research from India: A systematic review

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