Clozapine-induced persistent hiccup in a patient with Alzheimer's disease

Solla, Paolo; Perra, Enrica; Cannas, Antonino; Congia, S.; Secchi, Liz

doi:10.1016/j.clineuro.2005.05.012

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…Among the atypical antipsychotics, there are 2 case reports of hiccups because of aripiprazole, 4,5 1 each with clozapine, 3 and risperidone. 6 The first case of aripiprazole-induced hiccups was reported by Behere et al, 4 in which a 69-year-old man with a history of bipolar affective disorder developed hyponatremia complicated by persistent hiccups within 2 days of starting aripiprazole 10 mg/d in addition to sodium valproate 1000 mg/d.…”

Section: Discussionmentioning

confidence: 99%

Persistent Hiccups Associated With Switching From Risperidone to Aripiprazole in a Schizophrenic Patient With Cerebral Palsy

Yeh

2011

Clinical Neuropharmacology

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Antipsychotics are thought to be effective in the treatment of hiccups; however, they are rarely reported to induce hiccups. We report a case of persistent hiccups after administration of aripiprazole in a patient with concurrence of schizophrenia and cerebral palsy. Prior brain injury and switching antipsychotics may precipitate the development of hiccups in the present case. Aripiprazole with a partial agonist of dopamine D2 receptors and serotonin 1A receptors may play a crucial role in the pathophysiology of hiccups.

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Section: Discussionmentioning

confidence: 99%

Persistent Hiccups Associated With Switching From Risperidone to Aripiprazole in a Schizophrenic Patient With Cerebral Palsy

Yeh

2011

Clinical Neuropharmacology

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“…It is one of the rare reports in the literature [13] documenting this fact. Previously, hiccups resulting after aripiprazol and clozapine treatment were reported [2,3]. As we mentioned earlier, risperidone has the strongest affinity for D2 dopamine and 5-HT2 receptors; strongest affinity for α1 adrenergic, M muscarinic and H1 histamine receptors.…”

Section: Discussionmentioning

confidence: 70%

“…It is called intractable persistent hiccup when the duration of hiccup exceeds 48 h [3]. There are many factors which may cause hiccups.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risperidone-Induced Hiccups in an Adolescent

Rustamov¹,

Güneş²,

Doğangün³

2016

Azerbaijan Med Assoc J

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Hiccups are involuntary spasmodic contractions of the diaphragm and inspiratory intercostal muscles followed by sudden closure of glottis which leads to halting the start of an inspiration. There are many factors which may cause hiccups. Although the exact pathophysiological processes involved have not yet been established, the neurotransmitters dopamine, serotonin and gamma amino butyric acid (GABA) have been documented to play a significant role in the generation of hiccups. Here, we present a case of risperidone-induced hiccups in a 14-year old adolescent to discuss the probable causes, the etiology and the clinical outcomes of this side effect.

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“…8 However, not all antipsychotics behave the same way, and some of them, such as clozapine, have been reported to induce it. 9 The role of the GABAergic transmission is bimodal; the activation of GABA A receptors, through their benzodiazepine (BDZ) facilitators, is associated with the activation of the hiccup reflex, whereas stimulating GABA B receptors with agonists such as baclofen may lead to its suppression. 10 In fact, BDZs are associated with hiccup quite frequently 11 ; however, the GABA A agonist midazolam has been successfully used to treat it.…”

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confidence: 99%