Clozapine-induced palilalia?

Azevedo, Jacinto; Lopes, Rui; Curral, R.; Esteves, Mariana; Coelho, Rui; Roma-Torres, António

doi:10.1111/j.1601-5215.2011.00594.x

Cited by 5 publications

(3 citation statements)

References 9 publications

(13 reference statements)

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“…Palilalia can be seen in untreated schizophrenic patients, in paramedian thalamic damage, also in advanced stages of degenerative brain diseases such as Alzheimer's disease, and in cerebrovascular or traumatic lesions of the basal ganglia (Azevedo et al, 2012;Van Borsel, Bontinck, Coryn, Paemeleire, & Vandemaele, 2007) which the latter case is likely to be about our case.…”

Section: Introductionmentioning

confidence: 72%

The Clinical Outcome of Concurrent Speech Therapy and Transcranial Direct Current Stimulation in Dysarthria and Palilalia Following Traumatic Brain Injury: A Case Study

Bayat

Sabeti

Rao

et al. 2020

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Introduction: Dysarthria, a neurological motor speech disorder, is regarded as a common sequala of traumatic brain injury (TBI). Palilalia is a speech disorder characterized by involuntary repetition of words, phrases, or sentences. Based on the evidence supporting the effectiveness of transcranial direct current stimulation (tDCS) in some speech disorders, we hypothesized that using tDCS would enhance the expected speech therapy outcome in a case of TBI with dysarthria and palilalia. Method: The "Be Clear" protocol, a relatively new approach in speech therapy in dysarthria, together with tDCS were employed in this single case investigation. With respect to the tDCS montage, regions of interest (ROIs) were identified based on the comparative analysis of resting-state vs. speech task-concurrent qEEG results. Results: Measures of intelligibility, an important index in the assessment of dysarthria, were superior to the primary protocol results immediately and 4 months after intervention. We did not find any factor other than the use of tDCS to justify this superiority. Palilalia showed a remarkable improvement immediately after intervention but fell somewhat after 4 months. This might have been justified owing to the subcortical origin of palilalia. Conclusion: Our present findings suggested that applying tDCS together with speech therapy might be more effective in similar case profiles as compared to traditional speech therapy. This notion needs to be systematically investigated in well-designed parallel arm clinical trials.

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Section: Introductionmentioning

confidence: 72%

The Clinical Outcome of Concurrent Speech Therapy and Transcranial Direct Current Stimulation in Dysarthria and Palilalia Following Traumatic Brain Injury: A Case Study

Bayat

Sabeti

Rao

et al. 2020

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“…Basal ganglia involvement has been suggested as the culprit in some cases of palilalia. Palilalia can be seen in untreated schizophrenic patients, in paramedian thalamic damage, also in advanced stages of degenerative brain diseases such as Alzheimer's disease, and in cerebrovascular or traumatic lesions of the basal ganglia (Borsel et al, 2007, Azevedo et al, 2012 which the latter case is likely to be about our case.…”

Section: Introductionmentioning

confidence: 76%

The clinical outcome of concurrent speech therapy and transcranial direct current stimulation in dysarthria and palilalia following traumatic brain injury: A case study

Bayat¹,

Tahamtan²,

Sabeti³

et al. 2020

Preprint

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Purpose: Dysarthria, a neurological injury of the motor component of the speech circuitry, is of common consequences of traumatic brain injury (TBI). Palilalia is a speech disorder characterized by involuntary repetition of words, phrases, or sentences. Based on the evidence supporting the effectiveness of transcranial direct current stimulation (tDCS) in some speech and language disorders, we hypothesized that using tDCS would enhances the effectiveness of speech therapy in a client with chronic dysarthria following TBI. Method: We applied the constructs of the “Be Clear” protocol, a relatively new approach in speech therapy in dysarthria, together with tDCS on a chronic subject who affected by dysarthria and palilalia after TBI. Since there was no research on the use of tDCS in such cases, regions of interest (ROIs) were identified based on deviant brain electrophysiological patterns in speech tasks and resting state compared with normal expected patterns using the Quantitative Electroencephalography (QEEG) analysis. Results: Measures of perceptual assessments of intelligibility, an important index in the assessment of dysarthria, were superior to the primary protocol results immediately and 4 months after intervention. We did not find any factor other than the use of tDCS to justify this superiority. The percentage of repeated words, an index in palilalia assessment, had a remarkable improvement immediately after intervention but fell somewhat after 4 months. We justified this case with subcortical origins of palilalia. Conclusion: Our present case-based findings suggested that applying tDCS together with speech therapy may improve intelligibility in similar case profiles as compared to traditional speech therapy. To reconfirm the effectiveness of the above approach in cases with dysarthria following TBI, more investigation need to be pursued.

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“…A family with extensive intracerebral calcification was reported to present palilalia, and indeed patients with Fahr syndrome, an etiologically heterogeneous disorder, will often present this clinical sign. Further, palilalia was reported as ictal, autoimmune, and drug‐induced phenomenon (eg, with clozapine or cefepime).…”

Section: Methodsmentioning

confidence: 99%

The spectrum of involuntary vocalizations in humans: A video atlas

et al. 2019

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In clinical practice, involuntary vocalizing behaviors are typically associated with Tourette syndrome and other tic disorders. However, they may also be encountered throughout the entire tenor of neuropsychiatry, movement disorders, and neurodevelopmental syndromes. Importantly, involuntary vocalizing behaviors may often constitute a predominant clinical sign, and, therefore, their early recognition and appropriate classification are necessary to guide diagnosis and treatment. Clinical literature and video‐documented cases on the topic are surprisingly scarce. Here, we pooled data from 5 expert centers of movement disorders, with instructive video material to cover the entire range of involuntary vocalizations in humans. Medical literature was also reviewed to document the range of possible etiologies associated with the different types of vocalizing behaviors and to explore treatment options. We propose a phenomenological classification of involuntary vocalizations within different categorical domains, including (1) tics and tic‐like vocalizations, (2) vocalizations as part of stereotypies, (3) vocalizations as part of dystonia or chorea, (4) continuous vocalizing behaviors such as groaning or grunting, (5) pathological laughter and crying, (6) vocalizations resembling physiological reflexes, and (7) other vocalizations, for example, those associated with exaggerated startle responses, as part of epilepsy and sleep‐related phenomena. We provide comprehensive lists of their associated etiologies, including neurodevelopmental, neurodegenerative, neuroimmunological, and structural causes and clinical clues. We then expand on the pathophysiology of the different vocalizing behaviors and comment on available treatment options. Finally, we present an algorithmic approach that covers the wide range of involuntary vocalizations in humans, with the ultimate goal of improving diagnostic accuracy and guiding appropriate treatment. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Clozapine-induced palilalia?

Abstract: The appearance of palilalia induced by clozapine is a rare pharmacologic side-effect which physicians should be familiarised with when evaluating this symptom presentation.

Cited by 5 publications

References 9 publications

The Clinical Outcome of Concurrent Speech Therapy and Transcranial Direct Current Stimulation in Dysarthria and Palilalia Following Traumatic Brain Injury: A Case Study

The Clinical Outcome of Concurrent Speech Therapy and Transcranial Direct Current Stimulation in Dysarthria and Palilalia Following Traumatic Brain Injury: A Case Study

The clinical outcome of concurrent speech therapy and transcranial direct current stimulation in dysarthria and palilalia following traumatic brain injury: A case study

The spectrum of involuntary vocalizations in humans: A video atlas

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