Clozapine-Induced Myocarditis: A Rare Case of Myocarditis With Life-Threatening Implications

Shnoda, Mina; Sagalov, Andrew; Patel, Harsh; Siddique, Momin; Hegde, Shruti

doi:10.1016/s0735-1097(23)04225-0

Cited by 2 publications

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“…They are highly lipophilic, protein bound, and accumulate in the brain, lung, and other tissues, having a large volume of distribution. However, both typical and atypical antipsychotics have side effects that exist along a spectrum and are related to the unique receptor-binding profiles of each agent [ 63 , 64 , 65 ].…”

Section: Results Case Studies In Different Pharmacological Classesmentioning

confidence: 99%

“…At the cardiovascular level, clozapine most commonly causes myocarditis and cardiomyopathy. In this regard, Shnoda M., et al presented, in 2023 [ 65 ], a case of acute clozapine toxicity in a 47-year-old man diagnosed with schizophrenia, who arrived at the emergency department with persistent tachycardia. Cardiac magnetic resonance imaging (MRI) and modified Lake-Louise criteria led to the diagnosis of clozapine-induced myocarditis, and it was withdrawn from therapy, being replaced with risperidone [ 65 ].…”

Section: Results Case Studies In Different Pharmacological Classesmentioning

confidence: 99%

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Drugs Associated with Adverse Effects in Vulnerable Groups of Patients

Ștefan,

Nechita,

Dragostin

et al. 2024

Clinics and Practice

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In recent years, a series of recommendations have been issued regarding the administration of drugs because of awareness of the serious side effects associated with certain classes of drugs, especially in vulnerable patients. Taking into account the obligation of the continuous improvement of professionals in the medical fields and the fact that we are in the midst of a “malpractice accusations pandemic”, through this work, we propose to carry out a “radiography” of the scientific literature regarding adverse effects that may occur as a result of the interaction of drugs with the physiopathological particularities of patients. The literature reports various cases regarding different classes of drugs administration associated with adverse effects in the elderly people, such as fluoroquinolones, which can cause torsade de pointes or tendinopathy, or diuretics, which can cause hypokalemia followed by torsade de pointes and cardiorespiratory arrest. Also, children are more prone to the development of adverse reactions due to their physiological particularities, while for pregnant women, some drugs can interfere with the normal development of the fetus, and for psychiatric patients, the use of neuroleptics can cause agranulocytosis. Considering the physiopathological particularities of each patient, the drug doses must be adjusted or even completely removed from the treatment scheme, thus requiring the mandatory active participation both of clinician pharmacists and specialists in the activity of medical-pharmaceutical analysis laboratories within the structure of hospitals.

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Section: Results Case Studies In Different Pharmacological Classesmentioning

confidence: 99%

Section: Results Case Studies In Different Pharmacological Classesmentioning

confidence: 99%