"Clozapine-Induced Acute Interstitial Nephritis: A Case Report"

Acute Interstitial Nephritis Induced by Clozapine

“…New onset proteinuria, hematuria, and AKI after initiating treatment with clozapine and improvement in the kidney function parameters after cessation of treatment establish the casual relationship. To the best of our knowledge, clozapine-induced AIN has been reported only 16 times in the literature review [ 5 - 20 ]. The clinical characteristics, investigations, kidney injury outcomes have been summarized in Tables 2 and 3 .…”

“…Kidney biopsy was done in seven cases which confirmed the diagnosis [ 6 , 9 , 10 , 12 , 17 , 18 , 20 ]. Clozapine rechallenge was done in three cases [ 5 , 6 , 14 ], which resulted in the occurrence of AKI within a few days or with few doses. The dosage of clozapine ranged from 25 mg to 700 mg in the cases where AKI occurred [ 6 ].…”

“…Tubular inflammation with cellular infiltrates and interstitial edema is the distinctive feature noted on the kidney biopsy and establishes the diagnosis.New onset proteinuria, hematuria, and AKI after initiat-ing treatment with clozapine and improvement in the kidney function parameters after cessation of treatment establish the casual relationship. To the best of our knowledge, clozapineinduced AIN has been reported only 16 times in the literature review[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The clinical characteristics, investigations, kidney injury outcomes have been summarized in Tables…”