Clozapine: Current perspective

Solanki, Ram Kumar; Singh, P. P.; Swami, Mukesh Kumar

doi:10.4103/0019-5545.37668

Cited by 12 publications

(11 citation statements)

References 78 publications

(71 reference statements)

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“…This side effect is not considered to be dose dependent, but it may be the result of an idiosyncratic drug reaction. 7 , 8 There are case reports in the literature of patients that developed agranulocytosis due to several other antipsychotic medications. 5 , 6 Clinical trials and case reports have demonstrated that G-CSF is useful in treating clozapine-induced granulocytopenia by stopping agranulocytosis and increasing the number of granulocytes and macrophage precursors in the bone marrow.…”

Section: Discussionmentioning

confidence: 99%

Clozapine-Induced Febrile Neutropenia and Cellulitis

Yaylaci

Yilmaz

Güçlü

et al. 2014

Turkish Journal of Emergency Medicine

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Section: Discussionmentioning

confidence: 99%

Clozapine-Induced Febrile Neutropenia and Cellulitis

Yaylaci

Yilmaz

Güçlü

et al. 2014

Turkish Journal of Emergency Medicine

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“…Additionally, use of fluoroquinolones leads to the risks of adverse effects of interactions with psychotropic drugs (Fish, 2001). Ciprofloxacin apparently does not alter the elimination of some tranquilizers drugs like diazepam (Wijnands et al, 1990) however, causes clinically interaction with clozapine (Markowitz et al, 1997) , an anti-psychotropic drug usually prescribed for treatment of schizophrenia, bipolar disorder, psychotic refractory depression and Parkinson´s disease in psychotic patients (Solanki et al, 2007). As reported in a randomized double blind cross over study in schizophrenic inpatients, ciprofloxacin strongly inhibited clozapine metabolism associated to the increase in serum levels of clozapine and a metabolic derivative, Ndesmethylclozapine, (Raaska et al, 2000).…”

Section: Interaction Of Antibiotics With Drugs Used For Psychiatric Tmentioning

confidence: 99%

Urinary Tract Infections in Psychiatric Patients

Espuñes¹,

Serrano²,

Martínez³

2011

Urinary Tract Infections

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The results from a survey to estimate the prevalence of health care associated infections (HAI) indicated that UTIs were the most common type of HAI in acute and nonacute hospital inpatients; moreover, in non-acute hospital, 5% of psychiatric inpatients was affected by a HAI (Reilly et al., 2008). According to a prevalence survey done in Norway of infections among hospitalized patients, the psychiatry ward presented the lowest rate of hospital infections and the UTIs were the most common infections among inpatients (Hoving et al., 1981). In a cross sectional study performed to assess the prevalence of infections in psychiatric institutes in Belgium, reported that the UITs were the most common infections moreover, a statistically significant association with infection prevalence were found with the psychiatric diagnosis and duration of hospitalization (Haenen et al., 1997). In spite of epidemiologic assessment of UTIs has been difficult because are not reportable diseases (Foxman, 2002), reports of their incidence have been recorded in subpopulations that are at increased risk. At present, a special attention has been devoted to the study of nosocomial infections in long term care facilities (Nicolle, 2000) which include chronic diseases hospitals, rehabilitation centers, psychiatric hospitals, institutions for the mentally retarded and nursing homes. Nursing homes are a type of geriatric clinic that provide varying levels care (including psychiatric) for aged people, who for personal, social, health or other reasons, can not longer live alone or with their families (Chen et al., 2008) regrettably in some places, these clinics are not equipped with facilities and qualified personal as found in health institutions (Alameida & Pedroso, 1999). In fact, most of research on UTIs among the elderly has done on patients who are institutionalized in nursing homes (Chen et al., 2008; Nicolle, 2002) and hospitals (Foxmann, 2002). In elderly persons, the UTIs are usually asymptomatic i.e. the isolation of bacteria from urine in significant quantities is consistent with the infection, but without the local or systemic genitourinary signs or symptoms. Unlike the symptomatic patients with UTIs, in asymptomatic patients a positive urine culture does not confirm a diagnosis of UTI among this population. Further in geriatric patients, UTIs can be either uncomplicated infections that can occur in a normal genitourinary tract (Nicolle, 2000) or complicated infections characterized by structural or functional abnormalities by instrumentation such as indwelling urinary catheters (Hazeleltt et al., 2006). The prevalence surveys in nursing homes of different countries report that the frequency of asymptomatic bacteruria is 15-30% of men and 25-50% of women and symptomatic episodes contributed to morbidity in this population (Nicolle, 2000). The high frequency is favored by chronic comorbid conditions including mental deterioration, incontinence of bladder and bowel. The latter can associated to degenerative mental disorders such as Parki...

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“…Efficacy data for other SGA's in the treatment of refractory schizophrenics were inconclusive. [ 28 ]…”

Section: Treatment Of Resistant Schizophrenia With Atypical Antipsychmentioning

confidence: 99%

Current perspectives in the treatment of resistant schizophrenia

Solanki

Singh

Munshi

2009

Indian J Psychiatry

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This article summarizes the current knowledge base on the diagnosis and management of treatment resistant schizophrenia. While the prevalence of treatment resistant schizophrenia is definition dependent, estimates have ranged from 30% to up to 60%. This article first looks into the various diagnostic criteria of treatment resistant schizophrenia. Then the literature is reviewed about the pharmacotherapeutics of its management. Clozapine emerges to be the gold standard. In addition risperidone and high dose olanzapine also emerge as clinically useful options. Other emerging adjunctive treatment options are equally addressed.

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Clozapine: Current perspective

Abstract: The author conducted a review of studies that compared the efficacy, tolerability and indication for the use of clozapine in current perspectives for the treatment of resistant schizophrenia/ partial responders.

Cited by 12 publications

References 78 publications

Clozapine-Induced Febrile Neutropenia and Cellulitis

Clozapine-Induced Febrile Neutropenia and Cellulitis

Urinary Tract Infections in Psychiatric Patients

Current perspectives in the treatment of resistant schizophrenia

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