Cloxacillin in the Prophylaxis of Postoperative Infections of the Hip

Ericson, Carl; Lidgren, Lars; Lindberg, Lars

doi:10.2106/00004623-197355040-00015

Cited by 163 publications

(46 citation statements)

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“…Strictly aseptic routine in major hip operations seems highly necessary. In these operations special procedures such as steril enclosure (Charnley 1972) or even limited antibiotic prophylactic treatment (Ericson et al 1973 107 of the infections were classified as major. Analysis of the anatomic location and the type of operalion showed that the incidence of infection was highest for operations in hip regions.…”

Section: Late Results Of the Infectionmentioning

confidence: 99%

Post-Operative Wound Infections in Clean Orthopaedic Surgery:Review of a 5-year material

Lidgren

Lindberg

1974

Acta Orthopaedica Scandinavica

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Section: Late Results Of the Infectionmentioning

confidence: 99%

Post-Operative Wound Infections in Clean Orthopaedic Surgery:Review of a 5-year material

Lidgren

Lindberg

1974

Acta Orthopaedica Scandinavica

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“…Surgical antibiotic prophylaxis is one such strategy. At present, local and international guidelines recommend a single dose of cefazolin at the time of induction based on data from randomized control trials performed in the 1970s and 1980s (1,6,9,14,26). The guidelines stipulate, however, that the antibiotics chosen as prophylaxis should be selected to cover the most frequently encountered pathogens (6).…”

mentioning

confidence: 99%

Microbiological Aetiology, Epidemiology, and Clinical Profile of Prosthetic Joint Infections: Are Current Antibiotic Prophylaxis Guidelines Effective?

Peel

Cheng

Buising

et al. 2012

Antimicrob Agents Chemother

221

140

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ABSTRACTProsthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as a surgical antibiotic prophylaxis at the time of arthroplasty. This retrospective cohort study conducted across 10 hospitals over a 3-year period (January 2006 to December 2008) investigated the epidemiology and microbiological etiology of prosthetic joint infections. There were 163 cases of prosthetic joint infection identified. From a review of the microbiological culture results, methicillin-resistantStaphylococcus aureus(MRSA) and coagulase-negative staphylococci were isolated in 45% of infections. In addition, polymicrobial infections, particularly those involving Gram-negative bacilli and enterococcal species, were common (36%). The majority (88%) of patients received cefazolin as an antibiotic prophylaxis at the time of arthroplasty. In 63% of patients in this cohort, the microorganisms subsequently obtained were not susceptible to the antibiotic prophylaxis administered. The results of this study highlight the importance of ongoing reviews of the local ecology of prosthetic joint infection, demonstrating that the spectrum of pathogens involved is broad. The results should inform empirical antibiotic therapy. This report also provokes discussion about infection control strategies, including changing surgical antibiotic prophylaxis to a combination of glycopeptide and cefazolin, to reduce the incidence of infections due to methicillin-resistant staphylococci.

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“…The antibiotics mostly used have been cloxacillin (Ericson et al 1973). lincomycin (Schulitz et al 1980), and cefazolin (Hill et al 1981).…”

Section: Preventionmentioning

confidence: 99%

Hip arthroplasty infection: Current concepts

Antti-Poĭka

Josefsson

Konttinen

et al. 1990

Acta Orthopaedica Scandinavica

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Cloxacillin in the Prophylaxis of Postoperative Infections of the Hip

Cited by 163 publications

References 0 publications

Post-Operative Wound Infections in Clean Orthopaedic Surgery:Review of a 5-year material

Post-Operative Wound Infections in Clean Orthopaedic Surgery:Review of a 5-year material

Microbiological Aetiology, Epidemiology, and Clinical Profile of Prosthetic Joint Infections: Are Current Antibiotic Prophylaxis Guidelines Effective?

Hip arthroplasty infection: Current concepts

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