Clove and Its Active Compound Attenuate Free Fatty Acid-Mediated Insulin Resistance in Skeletal Muscle Cells and in Mice

Ghaffar, Safina; Afridi, Shabbir Khan; Aftab, Meha Fatima; Murtaza, Munazza; Hafizur, Rahman M.; Sara, Sara; Begum, Sabira; Waraich, Rizwana Sanaullah

doi:10.1089/jmf.2016.3835

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…As there is no direct evidence to validate that gut microbiota mediates the anti‐obese effect of melatonin, thus we cannot exclude the possibility that altered microbiota is due to the improved obesity or that other factors contribute to anti‐obese effect of melatonin, such as short‐chain fatty acids (SCFAs). SCFAs are the main products of dietary fiber fermentation by gut microbiota, and various studies confirm their mediatory effect on metabolic syndromes . For example, SCFA‐enriched diet prevents and reverses HF diet‐induced metabolic abnormalities via a PPARγ‐dependent switch from lipogenesis to fat oxidation .…”

Section: Introductionmentioning

confidence: 99%

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin

Han

et al. 2018

Journal of Pineal Research

320

277

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Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin's effects on body weight and lipid profiles and the potential mechanism of gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin

Han

et al. 2018

Journal of Pineal Research

320

277

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“…Clove also protects the stomach from ulcers and provides better liver function. Eugenol, the main component of clove oil, has strong antioxidant activity, as well [99,[101][102][103][104].…”

Section: Tablementioning

confidence: 99%

Nutritional Values and Therapeutical Effects of Mediterranean Herbs, Spices, and Medicinal Plants

Trajkovska-Broach¹,

Petkoska²

2023

Herbs and Spices - New Advances

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This chapter highlights the traditional use of Mediterranean edible plants, frequently used as herbs and spices in Mediterranean cuisine, and medicinal plants, used as natural therapeutics among the people in the Mediterranean region. The high phytonutrient content and diversity of these edible and nonedible wild plants in the Mediterranean are emphasized and their folk use is reviewed. The herbs, spices, and medicinal plants are vital constituents of the Mediterranean dietary pattern and lifestyle, known as the Mediterranean diet (MD). They significantly contribute to high antioxidant and anti-inflammatory character of the diet and its health and well-being benefits.

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“…increasing tyrosine phosphorylation, modifying distal insulin signaling by enhancing protein kinase B (PKB) and glycogen synthase kinase-3-β (GSK-3β) phosphorylation in muscle cells signaling. Thus, they decrease free fatty acid-mediated insulin resistance in mouse myogenic cells, increase glucose uptake, and promote insulin secretion in muscle cells (70). Mechanism of action for the antioxidant activity.…”

Section: Hypoglycemic Activitymentioning

confidence: 99%

Recent advances in nutritional composition, phytochemistry, bioactive, and potential applications of Syzygium aromaticum L. (Myrtaceae)

Xue¹,

Xiang²,

Wang³

et al. 2022

Front. Nutr.

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Syzygium aromaticum is an aromatic plant native to Indonesia, and introduced to tropical regions worldwide. As an ingredient in perfumes, lotions, and food preservation, it is widely used in the food and cosmetic industries. Also, it is used to treat toothache, ulcers, type 2 diabetes, etc. A variety of nutrients such as amino acids, proteins, fatty acids, and vitamins are found in S. aromaticum. In addition to eugenol, isoeugenol, eugenol acetate, β-caryophyllene and α-humulene are the main chemical constituents. The chemical constituents of S. aromaticum exhibit a wide range of bioactivities, such as antioxidant, antitumor, hypoglycemic, immunomodulatory, analgesic, neuroprotective, anti-obesity, antiulcer, etc. This review aims to comprehend the information on its taxonomy and botany, nutritional composition, chemical composition, bioactivities and their mechanisms, toxicity, and potential applications. This review will be a comprehensive scientific resource for those interested in pursuing further research to explore its value in food.

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Clove and Its Active Compound Attenuate Free Fatty Acid-Mediated Insulin Resistance in Skeletal Muscle Cells and in Mice

Cited by 8 publications

References 27 publications

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Nutritional Values and Therapeutical Effects of Mediterranean Herbs, Spices, and Medicinal Plants

Recent advances in nutritional composition, phytochemistry, bioactive, and potential applications of Syzygium aromaticum L. (Myrtaceae)

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