Cloud service for the differential clinical diagnostics of acute respiratory viral diseases (including those associated with highly contagious coronaviruses) with an application of methods of artificial intelligence

Zvyagintseva

Андрюков

et al. 2021

A&Ch

The review presents materials describing the seaweed-derived sulfated polysaccharides (SPS) as potential means for prevention and treatment of viral diseases of the respiratory tract, mainly inﬂuenza and COVID-19. The literature materials on the pathogenetic targets of inﬂuenza viruses and SARS-CoV-2, on the antiviral potential of SPS derived from red, brown and green algae, as well as on the mechanisms of antiviral action of these unique compounds are summarized. Seaweed SPS are characterized by high antiviral activity, good solubility, and almost complete absence of toxicity. Pathogens of respiratory infections do not form resistance under the SPS inﬂuence. The abovementioned facts allow us to consider these compounds as promising candidates for the creation of medicines, dietary supplements, and functional food products with antiviral and, above all, anti-inﬂuenza and anti-coronavirus activity on their basis in the future.

Section: Introductionunclassified

Seaweed-Derived Sulfated Polysaccharides as Potential Agents for Prevention and Treatment of Inﬂuenza and COVID-19

Zvyagintseva

Андрюков

et al. 2021

A&Ch

“…Natural foci of MERS-CoV are located on the Arabian Peninsula, and imported cases occur all over the world (the largest epidemic outbreak of MERS-CoV as a result of an imported case occurred in May-June 2015 in the Republic of Korea [30]. In 2019, severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2 -Severe Acute Respiratory Syndrome Coronavirus-2, Betacoronavirus, subgenus Sarbecovirus) was identified as the etiological agent of coronavirus disease (COVID-19 -Coronavirus disease 2019) [26,31,32], which has become a pandemic [25]. Currently, there is an urgent need to find effective treatments for COVID-19.…”

Section: взаимодействие лектинов с вирусамиmentioning

confidence: 99%

“…The genome of coronaviruses is represented by a single segment of positive polarity virion genomic RNA. ронавирус тяжёлого острого респираторного синдрома 2-го типа (SARS-CoV-2 -Severe acute respiratory syndrome coronavirus 2) (Betacoronavirus, подрод Sarbecovirus) как этиологический агент коронавирусного заболевания (COVID-19 -Coronavirus disease 2019) [26,31,32], которое приобрело масштаб пандемии [25]. В настоящее время существует острая необходимость в поиске эффективных методов лечения COVID-19.…”

Section: взаимодействие лектинов с вирусамиunclassified

Enveloped Viruses: Pathogenetic Targets for Cyanobacterial Lectins

Andryukov

Ermakova

et al. 2022

A&Ch

Лектины-группа углеводсвязывающих высокоспецифичных белков с широким спектром действия, участвующих в так называемой «первой линии» защиты организма. Эти уникальные биомолекулы проявляют высокую специфичность к различным моно-и олигосахаридам, в первую очередь, гликоконъюгатам вирусов и бактерий. Лектины цианобактерий эффективны против оболочечных вирусов и являются привлекательной альтернативой существующим синтетическим лекарственным препаратам. Известно практически полное отсутствие формирования резистентности у вирусов к этим соединениям. Цель обзора -анализ, обобщение и обсуждение результатов экспериментальных исследований in vivo и in vitro, иллюстрирующих механизмы действия и противовирусные эффекты лектинов, полученных из цианобактерий, в отношении наиболее опасных и социально значимых вирусов: SARS-Cov-2, ВИЧ, вирусов Эбола, гриппа и гепатита С. Кроме того, мы рассмотрим некоторые трудности, которые необходимо преодолеть для получения эффективных противовирусных препаратов в будущем.

“…В начале декабря 2019 г. в срединной китайской провинции Хубэй стали развиваться эпидемические события, связанные с новым коронавирусом, способным вызывать у людей тяжёлые (вплоть до летальных) первичные вирусные пневмонии [5]. Первый случай такой пневмонии был официально зарегистрирован в г. Ухань 08.12.2019 [6].…”

Section: Introductionunclassified

Polyphenols Sourced from Terrestrial and Marine Plants as Coronavirus Reproduction Inhibitors

Andryukov

Кузнецова

et al. 2021

A&Ch

The review presents the data of recent years concerning the most important modern problem — the search of the new inhibitors of coronaviruses’ reproduction. Polyphenolic compounds (phlorotannins) from terrestrial and marine plants, polyvalent bioregulators with multiple biological activity, are considered as promising compounds of this type. Polyphenols are able to interfere with different stages of coronaviruses’ life cycle. This fact characterizes polyphenols as multipurpose drugs that affect vital proteins of the pathogens. At the same time, the authors of the review draw attention to the fact that many difficulties must be overcome to develop medications based on plant polyphenols, since these compounds are characterized by complex structures, low bioavailability, as well as rapid excretion from the body. In addition, in vivo studies on animals, as well as in clinical trials, are required. Despite all the difficulties, plant polyphenols should eventually the source for creating antiviral medicines, biologically active food additives, and functional food products.