Cloud and HLB Temperatures of Polyglycerol Didodecanoate Solutions.

Kunieda, H.; Kaneko, Masaya; Fujiyama, Rika; Ishitobi, Masahiko

doi:10.5650/jos.51.379

Cited by 12 publications

(6 citation statements)

References 10 publications

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“…Polyglyceryl alkyl ethers or polyglycerol fatty acid esters have been studied with respect to phase behavior and self-assembly. − Thanks to the relatively strong intermolecular interaction among hydroxyl groups, polyglycerol-type surfactants have low monomeric solubility in oil and can effectively be adsorbed onto water–oil interfaces, which is a better feature than the poly(oxyethylene)-type emulsifier with relatively high monomeric solubility in oil. This feature also allows the formation of nonionic reverse micelles in oils. − The phase behavior of aqueous polyglycerol fatty acid esters was reported by Kunieda et al − They showed that the phase behavior was similar to general surfactant systems, in which a sphere–rod–planar shape transition took place depending on surfactant HLB or the critical packing parameter, due to a graft-copolymer type molecular structure. Therefore, we employed a molecular structure resembling that of phospholipids, i.e., one head and double tails.…”

Section: Introductionmentioning

confidence: 84%

Formation of Bilayer Membrane and Niosomes by Double-Tailed Polyglyceryl-Type Nonionic Surfactant

et al. 2015

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Vesicles with synthetic nonionic surfactants are called niosomes or NSVs, and these have been the focus of attention as an alternative to phospholipid liposomes as drug carriers. Especially it is demanded to discover novel niosomal systems with polyol-type nonionic surfactants from the viewpoint of environmental aspects. In this paper, a novel series of double-tailed nonionic surfactants, polyglyceryl dialkyl ethers, (C12)2Gn (n = 2.3, 5.4, 9.4, and 13.8), was synthesized, and its aqueous phase behavior and niosome formation were studied. Because of its double-tailed molecular structure, a lamellar liquid crystalline phase was dominant in the binary phase diagrams for different polyglyceryl chain lengths. The single lamellar liquid crystalline phase region was expanded as the polymerization degree in the hydrophilic moiety increased. Small-angle X-ray scattering spectra revealed the lamellar structure for the (C12)2G2.3 was extremely loose. Molecular packing in the lamellar phase was analyzed except for the (C12)2G2.3 system by using a geometrical model of the lamellar phase. The effective cross-sectional area per molecule at the interface increased extensively as dilution for the (C12)2G13.8 system but remained almost unchanged for the (C12)2G5.4 system. From the molecular parameters, water-holding ability in the lamellar phase was evaluated, and the results indicated strong hydration ability of the long polyglyceryl chain. In a dilute region, micron-sized giant niosomes and small niosomes of about 100 nm were formulated by vortex mixing and ultrasonication, respectively. The multilamellar structure of the small niosomes was confirmed by transmission electron microscopy. Cholesterol addition in the present surfactant lamellar phase induced the phase transition to the liquid ordered phase, which is the same phenomenon in a phospholipid-cholesterol mixture. The stability of niosomes with/without cholesterol was monitored by the niosome size change. In both cases, the niosomes were stable for at least 100 days.

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Section: Introductionmentioning

confidence: 84%

Formation of Bilayer Membrane and Niosomes by Double-Tailed Polyglyceryl-Type Nonionic Surfactant

et al. 2015

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“…Kuneda et al [120] investigated the effect of inorganic salts on the CP of micellar solutions of polyglycerol didodecanoate [(C 11 ) 2 G n ], a bio-friendly surfactant, as a function of the weight fraction of polyglycerol chain in whole surfactant, W H /W S , which is directly related to Griffin's HLB number [121]. A large decrease in CP was observed with the addition of NaCl and Na 2 SO 4 when compared with polyoxyethylene type nonionic surfactant as the concentration of salts increases at a fixed W H /W S .…”

Section: Effect Of Electrolytesmentioning

confidence: 99%

Clouding behaviour in surfactant systems

Mukherjee

Padhan

Dash

et al. 2011

Advances in Colloid and Interface Science

166

109

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“…Besides, the phase behavior of microemulsions in polyglycerol type nonionic surfactant systems is not largely influenced by temperature. [8][9][10][11][12] To our knowledge, there are not many studies on the phase behavior of these surfactants in oils. Diglycerol fatty acid esters (designated as Qn-D, where n is the carbon number in the alkyl chain length of amphiphile) are one of the edible surfactants and hence mostly are used for food products, cosmetics, and pharmacy.…”

Section: Introductionmentioning

confidence: 99%

Phase Behavior of Diglycerol Fatty Acid Esters−Nonpolar Oil Systems

et al. 2006

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Phase behavior of diglycerol fatty acid esters (Qn-D, where n represents the carbon number in the alkyl chain length of amphiphile, n = 10-16) were investigated in different nonpolar oils, liquid paraffin (LP70), squalane, and squalene. There is surfactant solid at lower temperature, and the surfactant solid does not swell in oil, and the melting temperature is almost constant in a wide range of compositions. In all of the systems, a lamellar liquid crystal (L(alpha)) is formed in a concentrated region at a temperature between the solid melting temperature and the isotropic two- or single-phase regions. In the dilute regions, reverse vesicles are formed in L(alpha) + O regions. There are two liquid-phase regions above the L(alpha) present region. This two-phase boundary corresponds to the cloud-point curve of nonionic surfactant aqueous solutions. However, instead of being less soluble in water at high temperature for the cloud point, the surfactant becomes more soluble in the organic solvents at high temperature. Namely, the effect of temperature on the solubility is opposite to the clouding phenomenon. When the hydrocarbon chain of the diglycerol surfactant decreases, the two-phase region becomes wider. In the case of a fixed surfactant, the surfactant is most miscible with squalene (narrowest two-phase regions) and the order of dissolutions tendency is squalene > LP70 > squalane. These results show that the hydrophilic moiety (diglycerol group) is more insoluble in oil compared with that of a conventional poly(oxyethylene)-type nonionic surfactant. Formation of reversed rodlike micelles was confirmed by SAXS scattering curve. When the hydrocarbon chain of surfactant is short, the micellar size becomes larger. In a fixed surfactant system, the reverse micellar size increases by changing oil from squalene to LP70. A small amount of water induces a dramatic elongation of reverse micelles.

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Cloud and HLB Temperatures of Polyglycerol Didodecanoate Solutions.

Cited by 12 publications

References 10 publications

Formation of Bilayer Membrane and Niosomes by Double-Tailed Polyglyceryl-Type Nonionic Surfactant

Formation of Bilayer Membrane and Niosomes by Double-Tailed Polyglyceryl-Type Nonionic Surfactant

Clouding behaviour in surfactant systems

Phase Behavior of Diglycerol Fatty Acid Esters−Nonpolar Oil Systems

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