Closure to “Assessment of Fire-Damaged Kuwaiti Structures” by Naji M. Al-Mutairi and Moneera S. Al-Shaleh

Al-Mutairi, Naji M.; Al-Shaleh, Moneera S.

doi:10.1061/(asce)0899-1561(1999)11:2(177)

Cited by 3 publications

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“…Treatment of pyridine-2-thione derivatives 1a-d [38] with aq. KOH in acetone furnished the corresponding potassium salts of 2-thioxopyridines (2a-d), which in turn were treated with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (3a) or 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl bromide (3b) to afford the S-glycosylated [15,[39][40][41][42][43][44][45][46][47] compounds 4a-h in good to high yields (50-99%) (Scheme 1). The structures of the S-glycoside 4a-h were confirmed by elemental analysis and spectral data (IR, 1 H-NMR, 13 C-NMR).…”

Section: Resultsmentioning

confidence: 99%

“…Then, our attention was directed to synthesize some of N-glycoside derivatives in order to examine the effect of glycoside linkage on activity. Treatment of compound 6 [38] with K 2 CO 3 or NaH in dimethylformamide (DMF) followed by the addition of 2,3,4,6-tetra-O-acetylα-D-glucopyranosyl bromide (3a) or 2,3,4,6-tetra-Oacetyl-α-D-galactopyranosyl bromide (3b) afforded the N-glycosylated nucleosides 8a,b [7,15,17,48] in good yields (50-60%) (Scheme 2). The suggested reaction mechanism was through the formation of the sodium/potassium salts of 2-oxopyridines (7) (Scheme 2).…”

Section: Resultsmentioning

confidence: 99%

“…These compounds containing glycoside bond have played a vital role as established cancer chemotherapeutic agents [3][4][5][6][7][8][9][10][11][12][13][14][15][16]. For example, N-nucleoside of pyridine-2-one and S-nucleoside of pyridine-2-thione derivatives are applied in the treatment of metastatic breast cancer, hairy cell leukemia, lung carcinoma cell line, liver carcinoma cell line, and brain carcinoma cell line [14][15][16][17][18][19]. In this context, dihydropyridine derivatives with glycoside bonds were identified as a strong P-glycoprotein antagonist with significant cytotoxic activity against human colon carcinoma cells ( Fig.…”

Section: Introductionmentioning

confidence: 99%

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Discovery of NewS‐Glycosides andN‐Glycosides of Pyridine‐biphenyl System with Antiviral Activity and Induction of Apoptosis inMCF7 Cells

Khodair

Attia

Gendy

et al. 2019

Journal of Heterocyclic Chem

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Glycosylation of small molecule‐based drugs can dramatically improve the biological activities of the parent scaffold. In the current study, S‐glycosides and N‐glycosides of polyfunctionalized pyridine‐biphenyl system tethered with benzotriazole moiety were designed and synthesized. S‐Glycosides of pyridine‐2‐thione derivatives 5a–h and N‐glycosides of pyridine‐2‐one derivatives 9a,b were synthesized by a facile, convenient, and high‐yielding procedure. The epimers glucose and galactose, acetylated or deacetylated, were used to form the glycone part. The structures of these compounds were confirmed by microanalysis and spectroscopic data (IR, 1H–NMR, and 13C‐NMR). The anticancer activities of the target compounds, in comparison with standard cisplatin, were assessed by MTT assay against MCF7 cell line. Compounds 4f, 4g, 5f, and 5h exhibited the highest cytotoxic effect on MCF7. The anticancer effect of these four compounds induced the apoptosis as evident by the up‐regulated expression of the apoptotic genes Bax and p53 and down‐regulated expression of the anti‐apoptotic gene BCl2. S‐Glycoside derivatives are more active than N‐glycosides. Moreover, the nontoxic doses of the tested compounds were evaluated in MA104, FRHK4, BGM, Hep2, and Vero cells. Compounds 4a–d and 5a–d were also evaluated for their antiviral effect against HSV‐1, HAV, and rotavirus Wa strain. The compounds' results showed less, moderated, and high antiviral activities. The docking study for these compounds with MDM2 revealed that deacetylated galactose is important for binding with the receptor as it facilitates the formation of hydrogen bond in the receptor. Rapid overlay of chemical structures analysis was employed to understand the compounds' similarity on the basis of their shape structure using the Tanimoto scores.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Discovery of NewS‐Glycosides andN‐Glycosides of Pyridine‐biphenyl System with Antiviral Activity and Induction of Apoptosis inMCF7 Cells

Khodair

Attia

Gendy

et al. 2019

Journal of Heterocyclic Chem

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“…5-Pyrazolones appear in solution in three different tautomeric forms (NH-form (171), CH-form (172), and OHform (173)), which were easily identified in NMR spectra. Mutairi et al [89] have irradiated the mixture of hydrazine derivatives and β-keto esters (170) with microwave (300 W) for 1-15 min under solvent-free condition, which produced pyrazolones in moderate to good yields (Scheme 46). Pyrazolones are also produced under conventional condition (stirring in EtOH, at room temperature for 1-5 h) [90].…”

Section: July 2015mentioning

confidence: 99%

Benign Approaches for the Microwave‐assisted Synthesis of Five‐membered 1,2‐N,N‐heterocycles

Kaur

2014

Journal of Heterocyclic Chem

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The development of new strategies for the synthesis of small‐sized heterocycles has remained a highly attractive but challenging proposition. An overview of the application of microwave irradiation in the synthesis of two nitrogen atoms containing five‐membered heterocyclic compounds is presented, focusing on the developments in the last 5–10 years. This contribution covers the literature concerning the total synthesis of five‐membered 1,2‐N,N‐heterocycles.

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“…5,6 As a result of the smaller load, the wastewater treatment plant might be designed more energy efficiently at a smaller footprint and might be built at lower investment costs. 7 Coagulation-flocculation process may be used as a pretreatment prior to biological treatment to enhance biodegradability of the wastewater during the biological treatment. 8 A number of workers have applied coagulation-flocculation technology for the treatment of papermaking wastewater.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment of papermaking‐reconstituted tobacco slice wastewater by coagulation–flocculation

Wang

Chen

et al. 2013

J of Applied Polymer Sci

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A study using coagulation-flocculation method for the treatment of papermaking-reconstituted tobacco slice wastewater had been carried out. Polyaluminum chloride (PAC) and polyferric sulfate (PFS) as coagulants, and four kinds of polyacrylamides (PAMs) as flocculants, were employed during the coagulation-flocculation process. The effects of three factors, that is, the dosage of coagulants, the dosage of flocculants and pH on the treatment efficiency of the process were evaluated. The results showed that the efficiencies of PAC and PFS on the reduction of COD, ammonia nitrogen (NH 3 -N) and total suspended solids (TSS) in the treated effluents were equivalent; however, the efficiency of PAC on the color reduction was much higher than that of PFS. In the presence of PAC, a cationic polyacrylamide with very high molecular weight and low charge density (i.e., PAM4) was found to give the highest coagulation-flocculation efficiency. At the optimal conditions, that is, pH of 6.5, PAC dosage of 500 mg/L, and PAM4 dosage of 5 mg/L, the reductions of COD, NH 3 -N, color, and TSS in the process were found to be 70.8, 84.8, 72.3, and 98.5%, respectively. The study also showed that the PAC-PAM4 scheme can remove the most of aluminum from the raw water.

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Closure to “Assessment of Fire-Damaged Kuwaiti Structures” by Naji M. Al-Mutairi and Moneera S. Al-Shaleh

Cited by 3 publications

References 0 publications

Discovery of NewS‐Glycosides andN‐Glycosides of Pyridine‐biphenyl System with Antiviral Activity and Induction of Apoptosis inMCF7 Cells

Discovery of NewS‐Glycosides andN‐Glycosides of Pyridine‐biphenyl System with Antiviral Activity and Induction of Apoptosis inMCF7 Cells

Benign Approaches for the Microwave‐assisted Synthesis of Five‐membered 1,2‐N,N‐heterocycles

Pretreatment of papermaking‐reconstituted tobacco slice wastewater by coagulation–flocculation

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