Closure of vertical alveolar bone defects with guided horizontal distraction osteogenesis: an experimental study in pigs and first clinical results

Expression of bone matrix proteins during de novo bone formation using a bovine collagen and platelet-rich plasma (prp)—an immunohistochemical analysis

“…Using a trephine drill (1 cm  1 cm, Roland Schmid, Fuerth, Germany) 6 identical bony defects were created. The size of the defects (10 mm diameter, 10 mm depth) met the requirements in dimension for a critical size defect in porcine species [27,28]. Without the use of a suitable augmentation material such defects are not completely regenerated with bone by the organism, but are partially filled with connective tissue [29].…”

Bioactivation of an anorganic bone matrix by P-15 peptide for the promotion of early bone formation

“…Using a trephine drill (1 Â 1 cm, Roland Schmid, Fuerth, Germany), 9 identical bony defects were created. The size of the defects (10 mm diameter, 10 mm depth) met the requirements in dimension for a critical size defect in porcine species [33,34]. Without the use of a suitable augmentation material such defects are not completely regenerated with bone, but are partially filled with connective tissue [35].…”

Juvenile Swine Surgical Alveolar Cleft Model to Test Novel Autologous Stem Cell Therapies

“…23 Finally, recent completion of the pig genome project 24 is facilitating the development of human disease models in swine that are currently only found in mice 25 ; consequently, development of swine surgical models will be a key step in initiating translational studies that address human conditions. To our knowledge, swine alveolar cleft models are reported in only three publications, 18,19,26 with a single report of a maxillary model to assess bone resorption after onlay bone grafting. 27 None of these models addresses a preclinical scenario to test tissue-engineered stem cell therapies.…”