Closure of Recurrent Cleft Palate Fistulas With Plasma Rich in Growth Factors

González-Sánchez, Jorge Glicerio; Jiménez-Barragán, Karina

doi:10.1016/j.otoeng.2011.06.001

Cited by 13 publications

(16 citation statements)

References 22 publications

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“…González‐Sánchez and Jiménez‐Barragán used autologous bone graft mixed with plasma rich in GFs to close recurrent cleft palate fistulas with a success rate of 90.9%, which was satisfactory compared to other literature with a recurrent rate ranging from 40% to nearly 100% …”

Section: Discussionmentioning

confidence: 99%

Use of autologous platelet-rich plasma in complete cleft palate repair

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Use of autologous platelet-rich plasma in complete cleft palate repair

et al. 2016

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“…It was stated by Cohen et al, [15] and Muzaffar et al, [3] that the rate of fistula occurrence increases according to the number of previous surgical attempts to manage the palatal fistulae. In addition, Gonzalez & Jiménez [6] claimed that they reduced the recurrence rate of fistula compared to other studies, by using PRP during the closure of recurrent cleft palate fistulae.…”

Section: Discussionmentioning

confidence: 99%

“…Gonzalez and Jimenez used PRP during closure of recurrent palatal fistulas as they claimed it reduced the recurrence rate of fistulas [6], the aim of this work is to study and evaluate the effect of PRP during palatal fistula repair and if it is helpful in decreasing the rate of recurrence of the fistulas.…”

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confidence: 99%

PRP Injection Effect on Palatal Fistula Repair: A Comparative Study

Emara

Makeen

Aboulhassan

2020

The Egyptian Journal of Plastic and Reconstructive Surgery

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Background: Palatal fistula after primary palate repair is an annoying problem for both patients and plastic surgeons. The incidence of fistula depends on the severity of the primary defect, the technique used for repair and the tension applied over the wound. Different methods are described for palatal fistula repair, starting from local mucoperiosteal flaps to free flaps.The recurrence rate of fistula after primary repair is about 23%, on the other hand the recurrence rate of fistula after its repair is higher as 25-33% up to 100%. Fistulas are classified according to its site and size. PRP is an autologous blood product, it promotes healing of wounds by its high platelet concentration and multiple growth factors, and also it decreases the risk of infection and increases neovascularization. PRP is used in several clinical applications as in oral maxillofacial, cardiac and plastic surgery.Methods: A comparative study was conducted on 20 patients with posterior palatal fistulas, who were divided into two groups, group A in which PRP was injected with fistula repair and group B fistula was repaired without PRP injection. Two flap palatoplasty (9 cases in each group) and Furlow technique (one case in each group) were used for both groups.Results: A total of 16 patients were followed-up for recurrence rate of fistulas, statistical analysis showed that in group A 25% had a recurrence, while in group B 50% of cases showed recurrence.Conclusion: PRP injection with the surgical repair of the palatal fistula has a role in decreasing the recurrence rate of the fistula and decreasing the need for further surgical interventions also, it is an easy, safe procedure and at an economic price.

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“…2 Platelet-rich plasma contains high levels of platelets and several growth factors playing key roles in cell regeneration, including platelet-derived growth factor (PDGF), transforming growth factor-b (TGF-b), vascular endothelial growth factor (VEGF), epidermal growth factor, fibroblast growth factor, and insulin-like growth factor 1 (IGF1). 5 Also, fibrin networks formed from PRP appear to reduce postoperative bone resorption. Such networks serve as osteoconductive scaffolds, providing matrices facilitating cell adhesion and osteoblast maturation.…”

Section: Discussionmentioning

confidence: 99%

“…11 In a prospective longitudinal study on recurrent cleft palate fistulae, complete closure was obtained in 90.9% of patients during 6 to 24 months; the recurrence rate was less than that with other techniques. 5 Growth factors enhance osteogenesis and remodeling of alveolar bone grafts in patients with cleft lips and/or palates, facilitating subsequent orthodontic therapy. 2,5,11 Platelet-rich plasma, however, may rapidly release all contained growth factors before cell outgrowth from surrounding the tissue, 12 which would significantly limit stimulation of bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

Interest of Mineralized Plasmatic Matrix in Secondary Autogenous Bone Graft for the Treatment of Alveolar Clefts

Nadon¹,

Chaput

Périssé³

et al. 2015

Journal of Craniofacial Surgery

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The authors describe a new material termed mineralized plasmatic matrix (MPM), a combination of platelets, fibrin concentrate, and autogenous bone to repair alveolar cleft defects. Autogenous cancellous bone is widely used to this end because such bone affords the functionalities (osteogenesis, osteoinduction, and osteoconduction) required for successful outcomes. To optimize these features, autologous blood products high in platelet concentrations have recently been developed. On the basis of our experience with PRP (platelet-rich plasma) and PRF (platelet-rich fibrin), we developed MPM, which contains platelets and fibrin concentrate in a liquid state; these materials can become bound to bone particles. The filling material is easy to shape and a PRF-type membrane is also generated. Ten patients with cleft lips and alveoli, with or without cleft palates (median, or uni- or bilateral) benefited from secondary bone grafts placed using our new material. We transferred autogenous bone from the iliac crest, an abundant source of cancellous bone associated with a high success rate. The 6-month outcomes of all patients were excellent in terms of both bone graft stability and closure of the oronasal fistulae. The preparation procedure is simple and the technical requirements minimal. Upon further optimization, MPM may serve as a third-generation platelet concentrate with potential applications in various fields.

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Closure of Recurrent Cleft Palate Fistulas With Plasma Rich in Growth Factors

Cited by 13 publications

References 22 publications

Use of autologous platelet-rich plasma in complete cleft palate repair

Use of autologous platelet-rich plasma in complete cleft palate repair

PRP Injection Effect on Palatal Fistula Repair: A Comparative Study

Interest of Mineralized Plasmatic Matrix in Secondary Autogenous Bone Graft for the Treatment of Alveolar Clefts

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