Closure of long surgical incisions with a new formulation of 2-octylcyanoacrylate tissue adhesive versus commercially available methods

Blondeel, Phillip; Murphy, John W.; Debrosse, Denis; Nix, James C.; Puls, Larry E.; Theodore, Nicholas; Coulthard, Paul

doi:10.1016/j.amjsurg.2004.04.006

Cited by 90 publications

(74 citation statements)

References 23 publications

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“…3 Subsequently, cosmetic results comparable with conventional wound closure have been attained in breast surgery, 4 paediatric surgery 5,6 and laparoscopic port site closure. 7,8 Furthermore, glue closure is faster compared to subcuticular suturing of incisions in inguinal hernia repair 9 and in body contouring surgery.…”

Section: A Blinded Randomised Controlled Trial Of Stapled Versus Timentioning

confidence: 99%

A Blinded, Randomised, Controlled Trial of Stapled Versus Tissue Glue Closure of Neck Surgery Incisions

Ridgway

Mahmood

Moore³

et al. 2007

annals

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Ann R Coll Surg Engl 2007; 89: 242-246 242Acceptable wound cosmesis and neck mobility are important outcomes following cervicotomy. Methods of skin closure vary in published series and are largely the result of surgeon choice based upon the need for a rapid, economic and reproducible technique of skin apposition. Recent advances in skin closure include the use of skin staples and tissue glues. Though each of these modalities has been evaluated against standard sutured methods in randomised clinical trials, no such comparison between these methods has been performed following cervicotomy. This blinded, randomised, controlled trial seeks to address this by comparing the speed and cosmetic results of cervicotomy closure using tissue glue or skin staples. Patients and MethodsThe trial protocol was reviewed and approved by local research ethics committee. The study population comprised patients undergoing primary cervicotomy for thyroid or parathyroid surgery at a single district general hospital. Primary outcome measure was time taken to complete skin closure. A power calculation yielded that 30 participants were required based on a halving of closure time with 80% power, an allocation ratio of 1:1 to glue and staple groups and a two-sided significance test at the 5% level. Secondary outcomes were neck mobility, scar cosmesis score and perioperative adverse event rates. Inclusion criteria were planned primary thyroid or parathyroid surgery in patients of the age and ability to give informed consent, with no known allergies to the products to be used and agreeing to randomisation procedure. Exclusion criteria were secondary neck surgery, history of poor compliance with medical treatments, allergy to products to be used or inability to give informed consent for inclusion or randomisation. Potential participants were identified at outpatient visits when the decision for surgical excision was Cosmetic acceptability of scar and neck mobility are important outcomes after collar line incision for neck surgery. This randomised, controlled trial compares these parameters in closures using tissue glue (Dermabond™, Ethicon, UK) and skin staples. HEAD AND NECK

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Section: A Blinded Randomised Controlled Trial Of Stapled Versus Timentioning

confidence: 99%

A Blinded, Randomised, Controlled Trial of Stapled Versus Tissue Glue Closure of Neck Surgery Incisions

Ridgway

Mahmood

Moore³

et al. 2007

annals

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“…Indeed, when compared with sutures for long incisions (range = 4 to 69 cm), highviscosity Dermabond adhesive had similar dehiscence rates and cosmetic results as sutures. 12 Unfortunately, no clinical trials have been reported using the newer octyl-based adhesives. A recent study of the intraabdominal pressures generated during various daily activities in volunteers may help put the measured bursting strength data into perspective.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives

Singer

Perry²

2012

Academic Emergency Medicine

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Objectives: Topical skin adhesives (TSAs) offer a noninvasive alternative to sutures. The growing trend is to use them in addition to sutures and staples to add strength and provide a microbial barrier. The authors compared the mechanical characteristics of recently approved TSAs that are most likely to be of surgical relevance in the emergency department.Methods: Linear incisions were made on anesthetized swine and the wounds were approximated with one of six commercially available TSAs. Three-dimensional bursting strength was measured with a BTC-2000TM device. Tensile failure force was measured ex vivo using TSA-approximated porcine skin strips with a tensionometer. Resistance to cyclic loading was measured by subjecting approximated skin strips to repetitive cycles of rotational torque and linear tension. Viscosity was measured with a viscometer and setting times were measured by periodically dabbing the adhesive applied to skin strips with a cotton swab to determine whether it was dry.Results: Dermabond Advanced TSA provided significantly (p < 0.00001) greater acute in vivo wound bursting strength and ex vivo tensile force, greater mean number of normal tensile loading cycles to failure (while under continuous torsional cycling), and longest time to failure, and the mean setting time was the shortest.

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“…No presente relato, a aplicação da correta técnica operatória, o uso externo em uma área de pele estática e frouxa, o contato por período curto com a superfície do corpo e a aplicação de mínima quantidade de adesivo foram os fatores atribuídos ao excelente resultado cosmético aos três meses pós-operatórios. Este resultado é preditivo de um ano 13 .…”

Section: Discussionunclassified

Reparo de fissura de lóbulo auricular usando cola cirúrgica de menor custo

Souza

Briglia²

2010

Rev. Bras. Cir. Plást. (Impr.)

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Rev. Bras. Cir. Plást. 2010; 25(4): 715-8 715Reparo de fissura de lóbulo auricular usando cola cirúrgica de menor custo Reparo de fissura de lóbulo auricular usando cola cirúrgica de menor custo Cleft earlob repair by use of low cost surgical glue RESUMO Introdução: As vantagens dos cianoacrilatos em síntese cutânea têm sido sobejamente demonstradas na literatura. Entretanto, estes produtos têm sido subutilizados no Brasil devido aos elevados custos do 2-octilcianoacrilato. Ademais, a forma mais economicamente acessível, o 2-etilcianoacrilato (ECA), tem sido pouco estudada como adesivo cutâneo. Relato do Caso: No caso descrito, os autores relatam a eficiência e as vantagens do fechamento de uma laceração de lóbulo auricular de uma criança usando o ECA de menor custo como alternativa à sutura.Descritores: Adesivos teciduais. Cianoacrilatos. Deformidades adquiridas da orelha. Orelha externa/lesões. ABSTRACT Background:The advantages of the cyanoacrylates in cutaneous synthesis have been frequently shown in the literature. However, these products have not been very used in Brazil due to the high costs of the 2-octilcyanoacrylate. Besides, the form more economically accessible, the 2-etilcyanoacrylate (ECA) has not been much studied as cutaneous adhesive. Case Report: The authors describe the efficiency and the advantages of a laceration closing of a child's earlobe using the low cost ECA as alternative to the suture.

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Closure of long surgical incisions with a new formulation of 2-octylcyanoacrylate tissue adhesive versus commercially available methods

Cited by 90 publications

References 23 publications

A Blinded, Randomised, Controlled Trial of Stapled Versus Tissue Glue Closure of Neck Surgery Incisions

A Blinded, Randomised, Controlled Trial of Stapled Versus Tissue Glue Closure of Neck Surgery Incisions

A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives

Reparo de fissura de lóbulo auricular usando cola cirúrgica de menor custo

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