Closure of large patent ductus arteriosus with a self‐expanding duct occluder in two dogs

Glaus, T M; Berger, F; Ammann, F. W.; Kiowski, Wolfgang; Ohlert, S.; Boller, Manuel; Kästner, Sabine; Reusch, Claudia E; Sisson, D. David

doi:10.1111/j.1748-5827.2002.tb00029.x

Cited by 25 publications

(18 citation statements)

References 15 publications

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“…c,3,5,10,13 Selfexpanding devices such as the Amplatzer Duct Occluder and the Amplatzer Vascular Plug, which are designed for PDA or peripheral vascular occlusion in human patients, respectively, have also been used for PDA occlusion in dogs. d, [6][7][8]11,12 However, the PDA in humans typically differs from that in dogs with respect to shape and minimal ductal diameter (MDD). 4,10 Consequently, we, in collaboration with a biomedical device company, e designed and developed a device, the Amplatz Canine Duct Occluder (ACDO), specifically for the canine ductus, as well as a per-catheter procedure for ACDO deployment.…”

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confidence: 99%

Minimally Invasive Per‐Catheter Patent Ductus Arteriosus Occlusion in Dogs Using a Prototype Duct Occluder

Nguyenba

Tobias

2008

Veterinary Internal Medicne

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Background: Per-catheter patent ductus arteriosus (PDA) occlusion in dogs with devices intended for humans is associated with technical difficulties, high rates of procedure abandonment, device migration, and residual ductal flow.Hypothesis: Use of a custom-made canine duct occluder (Amplatz Canine Duct Occluder, ACDO) would be feasible in dogs of varying weights and somatotypes and effective in occluding a wide range of PDA shapes and sizes.Animals: Eighteen client-owned dogs of various breeds with PDA. Weights ranged from 3.8 to 32.3 kg (median, 17.8 kg), and angiographic minimal ductal diameters ranged from 1.1 to 6.9 mm (median, 3.7 mm). Ductal morphologies included types IIA, IIB, and III.Methods: Per-catheter PDA occlusion with the ACDO was performed in all dogs. Persistent or recurrent ductal flow was assessed at the end of the procedure by angiography and at 1 day, 3 months, and !12 months after the procedure by echocardiography.Results: Successful ACDO placement was achieved in all 18 dogs. One dog required a 2nd procedure with a larger ACDO after the 1st device migrated to the pulmonary vasculature. Complete occlusion was confirmed in 17 of 18 dogs during the procedure, as well as at 1 day and 3 months after the procedure, and in 12 of 13 dogs evaluated at ! 12 months after the procedure.Conclusions and Clinical Importance: Per-catheter PDA occlusion in dogs with the ACDO is feasible and effective in dogs of a wide range of weights and somatotypes and with PDAs of varying shapes and sizes.

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confidence: 99%

Minimally Invasive Per‐Catheter Patent Ductus Arteriosus Occlusion in Dogs Using a Prototype Duct Occluder

Nguyenba

Tobias

2008

Veterinary Internal Medicne

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“…The risk of pulmonary arterial embolization has been reduced with the use of bioptome-assisted deployment of coils, detachable coil systems and devices intended for large PDA that include the Amplatzer ductal occluder and the Gianturco-Grifka vascular occlusion device. [27][28][29] In this case series, 4 of the 7 embolic events occurred in the 1st 17 procedures, whereas only 3 occurred in the subsequent 189 procedures. This most likely reflects both increased operator experience and availability of controlled release devices.…”

Section: Discussionmentioning

confidence: 80%

Pulmonary Embolization of Vascular Occlusion Coils in Dogs with Patent Ductus Arteriosus

Saunders

Miller

Gordon

et al. 2004

Veterinary Internal Medicne

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Transcatheter coil embolization of patent ductus arteriosus (PDA) was performed in 206 dogs between 1994 and 2003 at Texas A&M University, of which 7 (3%) had embolization of coils to the pulmonary vasculature. Thoracic radiographs indicated that coils were located in the right pulmonary artery in 6 of the 7 dogs. Pulmonary perfusion scans were available for review in 5 dogs, and moderate perfusion defects were observed in the right caudal lung lobe in 4 dogs within 24 hours of embolization. Perfusion deficits observed initially in 2 of the dogs resolved on perfusion scans performed at 6 months and 3.1 years. One dog did not have evidence of focal perfusion defects on a perfusion scan performed 4.5 months after embolization. All pulmonary embolizations occurred during the procedure. Attempts at retrieval of coils were unsuccessful in the 2 dogs in which it was attempted. No short-or long-term clinical complications were observed in any of the dogs with pulmonary embolization. We conclude that pulmonary embolization of vascular occlusion coils is an uncommon event and is not typically associated with adverse clinical effects in dogs with PDA.Key words: Canine; Congenital heart disease; Lung; Nuclear medicine.T raditionally, correction of patent ductus arteriosus (PDA) involves ductal ligation via a thoracotomy. Important complications of ductal ligation include hemorrhage, ductal rupture, and recanalization.1 In addition, morbidity associated with surgical treatment can be increased by thoracotomy and possible chest tube placement. In an attempt to minimize perioperative morbidity, transcatheter procedures have been developed for PDA occlusion, with coil embolization being among the most commonly employed.2 Although potential complications of transcatheter coil embolization have been addressed in the veterinary literature, a case series of pulmonary embolization of vascular occlusion coils has not been reported.2-4 The objective of this study was to describe the clinical outcome after inadvertent pulmonary embolization of vascular occlusion coils. Materials and MethodsThe medical records of 7 dogs referred for definitive therapy of PDA via transcatheter coil embolization, in which 1 or more vascular occlusion coils embolized to the pulmonary vasculature, were reviewed. Data regarding signalment, history, physical examination, thoracic radiographs, echocardiograms, coil embolization, pulmonary perfusion scans, postoperative clinical signs, and long-term follow-up were collected.Thoracic radiographs and echocardiography were performed before coil embolization in all dogs. A PDA was confirmed echocardiographically by documenting continuous flow in the pulmonary artery. In each dog, coil embolization procedures were performed via a right femoral artery approach.Eight pulmonary perfusion scans were available in 5 dogs. Six scans were accompanied by thoracic radiographs and were reviewed by a single investigator (Bahr). Pulmonary perfusion imaging was per- (Saunders, Miller, Gordon) Station, TX 77843-4474; e-mail: a...

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“…While there has been moderate success using human devices within the canine anatomy, limitations such as incompleteness of occlusion, device migration, delivery system size, and ease of delivery have prevented widespread use (Achen et al, 2008; Campbell et al, 2006; Glaus et al, 2002; Gordon and Miller, 2005; Hogan et al, 2006; Singh et al, 2012; Sisson, 2003; Tanaka et al, 2007; Tobias and Stauthammer, 2010) and led to the development of the Amplatz ® canine ductal occluder (ACDO) (Nguyenba and Tobias, 2007, 2008). The ACDO is very successful in PDA closure, yet is still limited by cost and its relatively large delivery system profile.…”

Section: Introductionmentioning

confidence: 99%

An experimental canine patent ductus arteriosus occlusion device based on shape memory polymer foam in a nitinol cage

Wierzbicki

Raines

Gordon

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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Patent ductus arteriosus (PDA) is a congenital cardiovascular defect in which a fetal connection between the aorta and pulmonary artery does not spontaneously close shortly after birth. If left uncorrected serious complications and even death can occur. Surgical ligation is the traditional treatment method; however, it is an invasive procedure, that motivates development of a minimally invasive option. Shape memory polymer (SMP) foams are unique materials that hold promise in the field of minimally invasive occlusion devices. In this work, a prototype nitinol foam cage (NFC) incorporating SMP foams has been designed and evaluated in multiple mechanical and in vitro verification tests. The NFC demonstrated acceptable fatigue resistance in a preliminary strut integrity test, withstanding one million cycles without complete strut fracture. Radial force analysis of both thick- and thin-walled prototype variations generated less vessel distension and wall tension in a vessel mimic compared to a commercial device. The NFCs exhibited negligible in vitro migration, comparable to that of a commercial device, using simplified, ideal models of PDA. Deployment characteristics of the prototypes were evaluated and compared to that of a commercial device when delivered into physiological models of PDA. During mock deployments, a veterinary cardiologist noted that, while deliverable, the thin-walled NFC prototype exhibited poor deployment characteristics, however the thick-walled NFC had deployment characteristics comparable to that of a commercial device. The promising results of this study warrant further investigation of the NFC device for canine PDA closure.

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Closure of large patent ductus arteriosus with a self‐expanding duct occluder in two dogs

Cited by 25 publications

References 15 publications

Minimally Invasive Per‐Catheter Patent Ductus Arteriosus Occlusion in Dogs Using a Prototype Duct Occluder

Minimally Invasive Per‐Catheter Patent Ductus Arteriosus Occlusion in Dogs Using a Prototype Duct Occluder

Pulmonary Embolization of Vascular Occlusion Coils in Dogs with Patent Ductus Arteriosus

An experimental canine patent ductus arteriosus occlusion device based on shape memory polymer foam in a nitinol cage

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