Closure of incision in cataract surgery in-vivo using a temperature controlled laser soldering system based on a 1.9μm semiconductor laser

Gabay, Ilan; Basov, Svetlana; Varssano, David; Barequet, Irina S.; Rosner, Mordechai; Rattunde, M.; Wagner, J.; Platkov, Max; Harlev, Mickey; Rossman, Uri; Katzir, Abraham

doi:10.1117/12.2209133

Cited by 3 publications

(11 citation statements)

References 13 publications

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“…In addition to the experiments, we also carried out theoretical calculations of the temperature distribution during irradiation. 20,[23][24][25][26][27] We tested our calculations at different values of T and t and found optimal conditions for T ≈ 60°C and t ≈ 10 s. This was also verified experimentally, and strong and watertight bonding, without noticeable thermal damage, was obtained. 28 Using this information, we succeeded in soldering incisions in vitro in skin, 29 bowel, 30 dura, 31 and trachea.…”

Section: Introductionsupporting

confidence: 60%

“…39 The radiation at this wavelength is fully absorbed within few hundred microns, so it heated the full thickness of the cornea. We previously established 24 that this operation generated strong bonding while ensuring no retinal damage.…”

Section: Choice Of Wavelengthmentioning

confidence: 99%

“…We developed a fiber-optic laser soldering system with an improved handpiece, combining two types of optical fibers arranged in a bundle. The bundle included a silica fiber, surrounded by 4 to 6 AgClBr fibers that had been made by the Applied Physics Group at Tel-Aviv University 24,35 and were highly transparent in the mid-IR. The silica fiber transmitted the 1.9-μm laser radiation from the proximal end to the distal end of the bundle to heat a spot of diameter of ≈2 mm on the incision.…”

Section: Beam Delivery and Temperature Controlmentioning

confidence: 99%

“…Again, strong bonding with very little scarring was obtained. 24,34 Recently, we used robotic laser soldering for bonding incisions in mouse skins in vitro and obtained a high bond strength. 35 Using this technique, we were able to deliver a measured amount of heat for a predefined amount of time, repeatably, thereby obtaining standardization and allowing for remote (e.g., daVinci System) operation or even an unaided one.…”

Section: Introductionmentioning

confidence: 99%

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Strong bonding of corneal incisions using a noncontact fiber-optic laser soldering method

et al. 2019

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Suturing of corneal incisions requires significant skill. We demonstrate a noncontact method that will simplify the bonding process. 5-mm-long penetrating vertical and slanted incisions were made in corneas of eyes, extracted from dead piglets. A fiber-optic laser system was used for laser soldering of the incisions, under close temperature control, using albumin solder. The burst-pressure P B immediately after the soldering was found to be P B ≈ 92 and 875 mmHg, for vertical and slanted incisions, respectively. P B ¼ 875 mmHg is an exceptionally high figure, ≈10 times the clinically acceptable value for sutured incisions. Laser soldering was then performed on penetrating incisions made in the corneas of live healthy piglets, of weight ≈10 Kg. After a healing period, the eyes were extracted, and the corneas were examined by histopathology and by optical coherence tomography. Our method immediately generated watertight and strong bonding without noticeable corneal shape distortion. These results would be beneficial for cataract surgery and for corneal transplantations. The fiber-optic system makes it much easier to bond corneal incisions. In the future, laser soldering could be automated and efficiently used by less experienced surgeons, thereby reducing the workload on the experienced ones.

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Section: Introductionsupporting

confidence: 60%

Section: Choice Of Wavelengthmentioning

confidence: 99%

Section: Beam Delivery and Temperature Controlmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Strong bonding of corneal incisions using a noncontact fiber-optic laser soldering method

et al. 2019

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“…However, the temperature of the heated spot was measured indirectly, with a thermocouple between the chitosan film and the tissue, thus reporting inaccurate results. To address this problem we developed a fiberoptic system for LTS under temperature control [33]. The system incorporates a bundle of fibers including a silica fiber for delivering the laser beam to heat a spot on the incision, and six infrared fibers for determining the temperature of the spot.…”

Section: Introductionmentioning

confidence: 99%

Robot-assisted laser tissue soldering system

Basov¹,

Milstein²,

Sulimani³

et al. 2018

Biomed. Opt. Express

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Fast and reliable incision closure is critical in any surgical intervention. Common solutions are sutures and clips or adhesives, but they all present difficulties. These difficulties are especially pronounced in classical and robot-assisted minimally-invasive interventions. Laser soldering methods present a promising alternative, but their reproducibility is limited. We present a system that combines a previously reported laser soldering system with a robotic system, and demonstrate its feasibility on the incision-closure of ex-vivo mice skins. In this demonstration, we measured tearing forces of ~2.5N, 73% of the tearing force of a mouse skin without an incision. This robot-assisted laser soldering technique has the potential to make laser tissue soldering more reproducible and revolutionize surgical tissue bonding.

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Laser Soldering of Cartilage Tissue to Collagenous Biomaterial (an in vitro Study)

Ignatieva,

Zakharkina,

Sviridov

2023

Sovrem Tehnol Med

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The aim of the study was to assess the effectiveness of laser soldering of biological tissues and materials for bulk heating of albumin solder on the joints of the intact and chemically modified cartilage of the porcine nasal septum.Materials and Methods. The materials for soldering were double-trypsinized and glyceraldehyde-treated plates made from cartilage of the porcine nasal septum, and intact cartilage. A 25% albumin solution was used as a solder. The junction was heated by laser radiation with the wavelengths of 1.56 and 1.68 µm through an optical fiber. The process was monitored using a digital USB microscope. After the materials were soldered, mechanical tests of the samples were conducted, and the fraction of intact collagen in the areas adjacent to the solder was determined. A thermal imager was used to record the dynamics of the temperature field in the area of laser exposure.Results. The effective soldering of cartilage tissue with collagenous biomaterial occurs with sequential application and laser heating of two/three layers of solder for radiation with wavelengths of 1.68/1.56 µm, respectively. The laser power densities for the solder layers were 0.7/0.8 W/mm 2 (the average surface temperature ~85°C) for λ=1.68 µm and 1.77/1.34/0.96 W/mm 2 (the average surface temperature ~100°C) for λ=1.56 µm. The tensile strength of the soldered samples reached ~12% for λ=1.56 µm and ~15% for λ=1.68 µm of the tensile strength of intact cartilage. In the tissue areas adjacent to the first layer of albumin, at a thickness of ~300 µm, most of the collagen network was destroyed. In other areas, collagen was predominantly preserved.Conclusion. Laser soldering of chemically modified and intact cartilages can be effectively conducted using radiation of λ=1.56 µm and λ=1.68 µm, absorbed not only by the solder, but also by the tissue. However, to minimize the area of degradation, it is necessary to match the diameter of the laser spot and the size of the solder-filled cavity between the construction and the intact cartilage.

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Closure of incision in cataract surgery in-vivo using a temperature controlled laser soldering system based on a 1.9μm semiconductor laser

Cited by 3 publications

References 13 publications

Strong bonding of corneal incisions using a noncontact fiber-optic laser soldering method

Strong bonding of corneal incisions using a noncontact fiber-optic laser soldering method

Robot-assisted laser tissue soldering system

Laser Soldering of Cartilage Tissue to Collagenous Biomaterial (an in vitro Study)

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