Clostridium welchii septicaemia after intrauterine caesium insertion.

Symonds, R.P.; Robertson, A.

doi:10.1136/bmj.1.6115.754-a

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Pyometra in the gynecologic setting, which is rarely seen before menopause, is concerning for an underlying uterine malignancy. Although uncommon, uterine infections specifically caused by Clostridium have been identified in the setting of various gynecologic malignancies ( Table 1 ) ( Lacey et al, 1976 , Symonds and Robertson, 1978 , Braverman et al, 1987 May , Kurashina et al, 2010 , Shetty et al, 2010 , Kremer et al, 2017 Sep ). Interestingly, claudin-3 and claudin-4 receptors, transmembrane proteins that mediate clostridium perfringens enterotoxin (CPE) binding and cytolysis, were found to be overexpressed in carcinosarcoma ( Santin et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Clostridium and Bacteroides bacteremia as initial presentation of uterine carcinosarcoma

Imo

Spirtos

Fomina

et al. 2022

Gynecologic Oncology Reports

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Section: Discussionmentioning

confidence: 99%

Clostridium and Bacteroides bacteremia as initial presentation of uterine carcinosarcoma

Imo

Spirtos

Fomina

et al. 2022

Gynecologic Oncology Reports

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“…We were able to identify only six other cases of clostridial sepsis in postmenopausal women in the literature. These women also had underlying uterine pathology, including four cases with uterine endometrial adenocarcinoma [ 8 – 10 ] and two cases with degenerating uterine leiomyoma [ 11 , 12 ]. Of the cases with endometrial adenocarcinoma, two were being treated with intrauterine radiocesium and the infection is thought to have been transmitted from one patient to the next.…”

Section: Discussionmentioning

confidence: 99%

Uterine Sarcoma Presenting with Sepsis from Clostridium perfringens Endometritis in a Postmenopausal Woman

Kao

Roy

Harter

et al. 2018

Case Reports in Obstetrics and Gynecology

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Clostridium perfringens is an anaerobic gram positive rod that is found in normal vaginal and cervical flora in 1–10% of healthy women. Uterine infection with Clostridium perfringens is seen rarely but is often related to underlying uterine pathology and can progress quickly to sepsis. Early recognition of sepsis, prompt treatment with antibiotics, and source control with surgical management allow for optimal chance of recovery. We present a case of a postmenopausal woman who presented with sepsis, vaginal bleeding, and back pain who was found to have Clostridium perfringens infection in the setting of undifferentiated uterine sarcoma.

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“…Uterine gas gangrene caused by Clostridium perfringens is a serious, often life-threatening infection that is most commonly seen in the peripartum period, with a dramatic decrease in incidence seen following the legalization of therapeutic abortions. In a non-pregnancy setting, most documented cases of uterine gas gangrene have been associated with underlying gynecologic malignancies ( Braverman et al, 1987 ; Kurashina et al, 2010 ; Symonds and Robertson, 1978 ; Lacey et al, 1976 ). There has been one documented case of uterine Clostridium perfringens infection associated with benign degenerating leiomoyoma ( Kaufmann et al, 1974 ).…”

Section: Discussionmentioning

confidence: 99%

Uterine Clostridium perfringens infection related to gynecologic malignancy

Kremer

McDonald

Goodheart

2017

Gynecologic Oncology Reports

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Uterine gas gangrene caused by Clostridium perfringens is a serious, often life-threatening infection that is rarely encountered in the practice of gynecologic oncology. However, the hypoxic nature of gynecologic cancers due to necrosis and/or prior radiation therapy creates a microenvironment optimal for proliferation of anaerobic bacteria such as the Clostridium species. Early recognition and aggressive treatment with IV antibiotics and surgical debridement remain the cornerstones of management in order to decrease morbidity and mortality. Here we present the case of a 52 year-old woman with a remote history of cervical cancer who was previously treated at our institution with primary chemotherapy and radiation and was then admitted decades later with Clostridium perfringens bacteremia and CT evidence of intrauterine abscess. The patient received a prolonged course of IV antibiotic therapy and subsequently underwent definitive surgical management with a total abdominal hysterectomy, bilateral salpingo-oophorectomy, small bowel resection with anastomosis for a utero-ileal fistula identified intraoperatively. Pathology from the uterine specimen demonstrated a primary poorly differentiated uterine adenocarcinoma. The patient recovered fully from her Clostridium perfringens infection and was discharged from the hospital shortly after surgical intervention.

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Clostridium welchii septicaemia after intrauterine caesium insertion.

Cited by 4 publications

References 2 publications

Clostridium and Bacteroides bacteremia as initial presentation of uterine carcinosarcoma

Clostridium and Bacteroides bacteremia as initial presentation of uterine carcinosarcoma

Uterine Sarcoma Presenting with Sepsis from Clostridium perfringens Endometritis in a Postmenopausal Woman

Uterine Clostridium perfringens infection related to gynecologic malignancy

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