Clostridium Welchii Resistance to Tetracycline

Johnstone, F. R. C.; Cockcroft, W. H.

doi:10.1016/s0140-6736(68)92098-9

Cited by 24 publications

(15 citation statements)

References 1 publication

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“…Rifampin inhibited all but one strain at 0.015 ,ug/ml; the remaining strain was 500-fold more resistant. DISCUSSION Our results for penicillin G agree with those of others who used similar methods (6,8,9,13). The semisynthetic penicillins tested were also active against C. perfringens.…”

Section: Resultssupporting

confidence: 92%

“…Cefazolin, cefoxitin, and cephradine showed activity comparable to the other cephalosporins. Our results with chloramphenicol and clindamycin were similar to those of others (6,8,9,13). We also found resistance to tetracyclines among strains of C. perfringens (6,8,9,13).…”

Section: Resultssupporting

confidence: 91%

“…Our results with chloramphenicol and clindamycin were similar to those of others (6,8,9,13). We also found resistance to tetracyclines among strains of C. perfringens (6,8,9,13). About half of our strains were inhibited by 1 ,g of tetracycline per ml, but 64 ,ug/ml was required to inhibit 100% of strains; 21% of strains required more than 1 ,ug of doxycycline per ml.…”

Section: Resultssupporting

confidence: 90%

“…Penicillin G is the antibiotic of first choice for treating cellulitis, sepsis, and myonecrosis caused by Clostridium perfringens (1, 2, 8,11,18). Although erythromycin and tetracycline are the alternative drugs usually recommended (1, 2, 8, 11, 18), 10 to 30% of C. perfringens are resistant to tetracycline, and a few strains are also resistant to erythromycin (6,8,9,13).…”

mentioning

confidence: 99%

“…Although erythromycin and tetracycline are the alternative drugs usually recommended (1, 2, 8, 11, 18), 10 to 30% of C. perfringens are resistant to tetracycline, and a few strains are also resistant to erythromycin (6,8,9,13). Cephalosporins and penicillinase-resistant and other semisynthetic penicillins are used for contaminated wounds after severe trauma and for suspected sepsis in patients with cancer, who are also at a higher risk for clostridial infections (3,4,14).…”

mentioning

confidence: 99%

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Susceptibility of Clostridium perfringens Isolated from Human Infections to Twenty Antibiotics

1977

Antimicrob Agents Chemother

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The proper choice of antibiotic for Clostridium perfringens infections in patients allergic to penicillin is not dear; the usual recommendations and recent in vitro studies disagree. We tested the susceptibility of 57 strains ofC. perfringens to eight penicillins, seven cephalosporins, two tetracyclines, clindamycin, chloramphenicol, and rifampin by the agar dilution method. All strains were inhibited by (per milliliter) 4 ,ug or less of any of the penicillins, chloramphenicol, or clindamycin and 8 ,mg or less of any of the cephalosporins tested. Penicillin G and amoxicillin inhibited all strains at 0.12 ,g or less per ml. Only 54% of the strains were inhibited by 1 ,ug of tetracycline per ml. Penicillin G remains the drug of first choice for infections with C. perfringens; it need not be added to a regimen containing a penicillinase-resistant penicillin given parenterally in high doses. The cephalosporins should be considered as alternative drugs for penicillin-allergic patients. Clindamycin and chloramphenicol are also effective. Tetracyclines cannot be depended upon in clostridial infections without in vitro testing, which is impracticable for initial empirical therapy.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 90%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Susceptibility of Clostridium perfringens Isolated from Human Infections to Twenty Antibiotics

1977

Antimicrob Agents Chemother

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Clostridial Myonecrosis ('Gas Gangrene') During Cephalosporin Prophylaxis

Mohr¹

1978

JAMA

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Four cases of clostridial myonecrosis that developed in open fractures were treated with surgical debridement and with intravenous cephalosporins as antibiotic prophylaxis. All patients recovered following amputation of the involved extremity, and treatment with high-dose penicillin in three cases, and erythromycin plus high-dose cephalothin in the fourth. This complication was not seen in patients with similar injuries that were managed surgically but used other antibiotics, usually penicillin, as prophylaxis. In vitro susceptibility tests of clostridia to cephalothin were performed; the results demonstrated that nearly 50% of clostridia tested were resistant to cephalothin.

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An investigation into the spread of bacterial infection in lower-limb amputations

Weaver

Chattopadhyay

Angel

1973

Journal of British Surgery

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An investigation into the spread of bacterial infection in lower‐limb amputations carried out for ischaemia and terminal gangrene of the limb is reported. Under the conditions described in the study the spread of infection through the deep tissues of the leg does not appear to be as important as external infection which occurs following contamination in the operating theatre or in the ward when the wound remains unhealed. In many cases where bacterial contamination or infection of the amputation site occurred the organisms responsible had also been isolated from the gangrenous lesions in the limb. Thus documentation of the bacterial flora at the gangrenous site should not be ignored.

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Clostridium Welchii Resistance to Tetracycline

Cited by 24 publications

References 1 publication

Susceptibility of Clostridium perfringens Isolated from Human Infections to Twenty Antibiotics

Susceptibility of Clostridium perfringens Isolated from Human Infections to Twenty Antibiotics

Clostridial Myonecrosis ('Gas Gangrene') During Cephalosporin Prophylaxis

An investigation into the spread of bacterial infection in lower-limb amputations

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