Clostridium septicum-infected aortic aneurysm or graft is a deadly diagnosis

Lehman, Bethany; Miller, Ryan M.; Richter, Sandra; Keller, George; Tan, Carmela D.; Rodríguez, E. René; Roselli, Eric E.; Rehm, Susan J.

doi:10.1016/j.jvs.2019.09.029

Cited by 10 publications

(19 citation statements)

References 53 publications

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“…Mycotic aortic arch aneurysm caused by Clostridium perfringens is a life-threatening disorder. In fact, the mortality rate is 100% if untreated [ 4 ]. Herein, we report a patient with a mycotic aortic arch aneurysm caused by C. perfringens who subsequently underwent a semi-urgent total arch replacement.…”

Section: Introductionmentioning

confidence: 99%

Mycotic Aortic Arch Aneurysm Caused by Clostridium perfringens

Oishi¹,

Asai²,

Kajimoto³

et al. 2022

Cureus

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We report a case of a 79-year-old man for a mycotic aortic arch aneurysm caused by Clostridium perfringens . The patient who had been hospitalized for cholangitis two months prior revisited the hospital for fever and left precordial pain. He was suspected of an infected aortic aneurysm in the distal arch due to emphysematous changes observed. After antibiotics treatment, the emphysematous changes disappeared. However, he underwent urgent total arch replacement due to a new ulcer-like projection and enlargement of the aortic aneurysm, which were observed at that time. Clostridium-infected infectious aneurysms require not only treatment for vascular lesions but also scrutiny of complications, such as cancer.

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Section: Introductionmentioning

confidence: 99%

Mycotic Aortic Arch Aneurysm Caused by Clostridium perfringens

Oishi¹,

Asai²,

Kajimoto³

et al. 2022

Cureus

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“… 1 , 2 Additionally, C. septicum aortitis is associated with occult gastrointestinal malignancies (≤80%; 56% of colorectal cancer) and hematologic disorders. 1 , 2 Alpha toxin production can lead to gas gangrene building up in the aortic wall and, ultimately, systemic invasion through the bowel mucosa, resulting in fast aneurysm induction accompanied by a high risk of rupture. 2 , 3 , 4 However, few cases have been reported (n = 72).…”

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confidence: 99%

“… 1 , 2 Alpha toxin production can lead to gas gangrene building up in the aortic wall and, ultimately, systemic invasion through the bowel mucosa, resulting in fast aneurysm induction accompanied by a high risk of rupture. 2 , 3 , 4 However, few cases have been reported (n = 72). When open aortic repair (OAR) is not performed, C. septicum aortitis will result in a 100% 6-month mortality rate.…”

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confidence: 99%

“…When open aortic repair (OAR) is not performed, C. septicum aortitis will result in a 100% 6-month mortality rate. 2 Rupture of the abdominal aorta (77%-94% mortality for outpatients compared with 51.9% in-hospital mortality) is in contrast to a 90-day mortality of ∼30% after OAR. 2 , 5 , 6 …”

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confidence: 99%

“… 2 Rupture of the abdominal aorta (77%-94% mortality for outpatients compared with 51.9% in-hospital mortality) is in contrast to a 90-day mortality of ∼30% after OAR. 2 , 5 , 6 …”

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confidence: 99%

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