Clostridium ramosum Osteomyelitis in an Immunocompetent Patient After Traumatic Injury

Dahya, Vishal; Ramgopal, Moti; Collin, Berjan; Robinson, Marjorie

doi:10.1097/ipc.0000000000000209

Cited by 6 publications

(15 citation statements)

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“…ramosum infections are rare and were mostly reported in young patients (<5 y.o.) suffering from inner ear infections or in immunocompromised elderly people (Forrester Joseph and Spain David, 2014;Dahya et al, 2015). Clinical presentations encompass a variety of cases: gas gangrene, pseudomembranous colitis, acute otitis media, non-autoimmune hemolytic anemia, pyelonephritis, brain or lung abscess, peritonitis, spondylodiscitis, osteomyelitis, arthritis, bacteremia and septicemia (Dahya et al, 2015;Lavigne et al, 2003;Alcalde-Vargas et al, 2012;García-Jiménez et al, 2016;van der Vorm et al, 1999;Gerber et al, 2018;Mohandas et al, 2001;Al-kali et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…The first case of spondylodiscitis due to E. ramosum in an elderly immunocompetent patient without a specific history of bone infections was reported in 2003 (Lavigne et al, 2003). Recently, E. ramosum was detected in a tibia of a young immunocompetent individual after a traumatic fracture and an amputation above knee was performed after treatment failure (Dahya et al, 2015). Here, we present a new case of septic pseudarthrosis due to E. ramosum in a young adult patient presenting complications to plate osteosynthesis stabilization following a pathological fracture.…”

Section: Introductionmentioning

confidence: 99%

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Molecular diagnosis and enrichment culture identified a septic pseudoarthrosis due to an infection with Erysipelatoclostridium ramosum

Zakham

Pillonel

Brunel

et al. 2019

International Journal of Infectious Diseases

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We describe here a rare case of septic pseudarthrosis due to Erysipelatoclostridium ramosum in a female young patient. The patient, currently in remission from Ewing's sarcoma treated by a bone resection and allograft combined with chemotherapy, suffered from a chronic femoral pseudarthrosis in a context of bone insufficiency and graft resorption. A broad range 16S PCR followed by sequencing, as well as an enrichment culture of a bone biopsy revealed the presence of E. ramosum, an anaerobic firmicute with a low Gram-positive affinity staining and low GC content, that was further characterized by whole genome sequencing (WGS).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular diagnosis and enrichment culture identified a septic pseudoarthrosis due to an infection with Erysipelatoclostridium ramosum

Zakham

Pillonel

Brunel

et al. 2019

International Journal of Infectious Diseases

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“…For all these reasons, the 16S rRNA gene needs to be sequenced to confirm the identification [1,9]. These factors probably lead to underreporting of this clostridial species in human infections [28].…”

Section: Case Presentationmentioning

confidence: 99%

“…CRB particularly occurs in adults predisposed to infection because of underlying malignancy and immunosuppression, and patients with bowel perforation and abscess formation [6,31,32], but also in immunocompetent patients [28]. CRB has comprised 0-13 % of CB in published retrospective case series [4,33].…”

Section: Case Presentationmentioning

confidence: 99%

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Clostridium ramosum rapidly identified by MALDI-TOF MS. A rare gram-variable agent of bacteraemia.

Legaria

García

Tudanca

et al. 2020

Access Microbiology

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Clostridium ramosum is an enteric anaerobic, endospore-forming, gram-positive rod with a low GC content that is rarely associated with disease in humans. We present a case of C. ramosum bacteraemia. To the best of our knowledge, this is the second case of C. ramosum bacteraemia in an elderly patient presenting with fever, abdominal pain and bilious emesis. We highlight the Gram stain variability, the lack of visualization of spores and the atypical morphology of the colonies that showed C. ramosum in a polymicrobial presentation that initially appeared to show monomicrobial bacteraemia. The microorganism was rapidly identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). We present a comprehensive literature review of 32 cases of clinical infections by C. ramosum in which we describe, if available, sex, age, clinical symptoms, predisposing conditions, other organisms present in the blood culture, other samples with C. ramosum, identification methodology, treatment and outcome.

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Limosilactobacillus fermentum, Lactococcus lactis and Thomasclavelia ramosa are enriched and Methanobrevibacter smithii is depleted in patients with non-alcoholic steatohepatitis

Mbaye

Wasfy

Alou

et al. 2023

Microbial Pathogenesis

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Clostridium ramosum Osteomyelitis in an Immunocompetent Patient After Traumatic Injury

Cited by 6 publications

References 10 publications

Molecular diagnosis and enrichment culture identified a septic pseudoarthrosis due to an infection with Erysipelatoclostridium ramosum

Molecular diagnosis and enrichment culture identified a septic pseudoarthrosis due to an infection with Erysipelatoclostridium ramosum

Clostridium ramosum rapidly identified by MALDI-TOF MS. A rare gram-variable agent of bacteraemia.

Limosilactobacillus fermentum, Lactococcus lactis and Thomasclavelia ramosa are enriched and Methanobrevibacter smithii is depleted in patients with non-alcoholic steatohepatitis

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