Clostridium perfringens α toxin damages the immune function, antioxidant capacity and intestinal health and induces PLCγ1/AMPK/mTOR pathway-mediated autophagy in broiler chickens

Zhang, Tong; Wang, Xiaohui; Li, Wenli; Wang, Heliang; Yan, Lei; Zhao, Lianwen; Zhang, Xiaowen; Wang, Nianxue; An, Wendong; Liu, Tongyue; Fan, Wenlei; Zhang, Beibei

doi:10.1016/j.heliyon.2024.e26114

Cited by 1 publication

(1 citation statement)

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“…However, the role of AIM2 in pathogenic C. perfringens infection has not been reported. Infection with pathogenic C. perfringens can lead to necrotizing enterocolitis, small intestinal colitis, intestinal toxemia, gas gangrene, systemic diseases, and diarrhea [27,28]. These clostridial diseases not only cause incalculable economic losses to the livestock industry, but also pose a risk to human health.…”

Section: Discussionmentioning

confidence: 99%

Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Clostridium perfringens Infection

Ma,

Lou,

Wang

et al. 2024

IJMS

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Absent in melanoma 2 (AIM2), a key component of the IFI20X/IFI16 (PYHIN) protein family, is characterized as a DNA sensor to detect cytosolic bacteria and DNA viruses. However, little is known about its immunological role during pathogenic Clostridium perfringens (C. perfringens) infection, an extracellular bacterial pathogen. In a pathogenic C. perfringens gas gangrene model, Aim2−/− mice are more susceptible to pathogenic C. perfringens soft tissue infection, revealing the importance of AIM2 in host protection. Notably, Aim2 deficiency leads to a defect in bacterial killing and clearance. Our in vivo and in vitro findings further establish that inflammasome signaling is impaired in the absence of Aim2 in response to pathogenic C. perfringens. Mechanistically, inflammasome signaling downstream of active AIM2 promotes pathogen control. Importantly, pathogenic C. perfringens-derived genomic DNA triggers inflammasome signaling activation in an AIM2-dependent manner. Thus, these observations uncover a central role for AIM2 in host defense and triggering innate immunity to combat pathogenic C. perfringens infections.

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Section: Discussionmentioning

confidence: 99%