Clostridium perfringens Liver Abscess Complicated With Bacteremia

Rives, Charles; Chaudhari, Dhara; Patel, P.G.; Swenson, James; Reddy, Chakradhar; Young, Mark

doi:10.14309/00000434-201510001-00836

Cited by 3 publications

(2 citation statements)

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“…In these cases, alpha-toxin secreted by C. perfringens is considered to be the main toxin, which is responsible for intravascular hemolysis, disseminated intravascular coagulopathy (DIC) (12,13), and multiple organ failure. Although the number of reported cases with spontaneous C. perfringens sepsis is increasing (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), appropriate treatment strategies have not been established.…”

Section: Accepted Manuscript 1 Introductionmentioning

confidence: 99%

Spontaneous Non-Traumatic <i>Clostridium perfringens</i> Sepsis

Hifumi

2020

Jpn J Infect Dis

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Section: Accepted Manuscript 1 Introductionmentioning

confidence: 99%

Spontaneous Non-Traumatic <i>Clostridium perfringens</i> Sepsis

Hifumi

2020

Jpn J Infect Dis

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“…Belonging to the family of Clostridiaceae, it was first described by Andrewes and Klein in the 1890s. This bacterium is grows rapidly, showing a doubling rate of 7 min [2] . C. perfringens can be found everywhere in nature and is a component of the human intestinal and genital tract.…”

Section: Introductionmentioning

confidence: 99%

Liver abscess and sepsis caused by Clostridium perfringens and Klebsiella oxytoca

Paasch

Wilczek

Strik

2017

International Journal of Surgery Case Reports

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Gas in the myocardium: a fatal presentation of Clostridium perfringens: a case report

Khan

Yousaf

Ahmad

et al. 2022

European Heart Journal - Case Reports

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Background Clostridium perfringens is a well-known cause of gas gangrene with a very high mortality rate. Multiple cases of internal organs have been reported in the literature; however, non-traumatic spontaneous gas gangrene due to Clostridium perfringens with solely cardiac involvement in a patient without any risk factors has not been reported before. Case Summary A 52-year-old male presented to the emergency department with chest pain and exertional dyspnea for 3 days. The patient was hemodynamically stable initially, and the physical examination was unremarkable. Initial laboratory workup revealed elevated d-dimer and troponin levels. Computerized tomography (CT) of the chest was negative for pulmonary embolism but showed a hypodense focus in the cardiac silhouette. Acute coronary syndrome protocol was initiated; however, invasive cardiac workup was negative. The patient had rapid clinical deterioration with development of respiratory failure, shock and multiorgan failure within 24 hours. A transesophageal echocardiogram demonstrated an abnormal echogenic focus, corresponding to CT chest area. Despite aggressive treatment, the patient passed away within 36 hours. Later, the patient’s blood culture grew clostridium perfringens. A limited autopsy showed an abscess cavity in the interventricular septum, pathology of which revealed acute myocarditis and fibrinous pericarditis. Discussion Unlike other reported cases of C. perfringens with cardiac abscess, our patient had no known risk factors, and no other organs were involved. We conclude from this case that an air focus on the CT scan in the myocardium can be suggestive of a spontaneous gas gangrene of the myocardium, and the patients should be treated accordingly.

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Clostridium perfringens Liver Abscess Complicated With Bacteremia

Cited by 3 publications

References 0 publications

Spontaneous Non-Traumatic <i>Clostridium perfringens</i> Sepsis

Spontaneous Non-Traumatic <i>Clostridium perfringens</i> Sepsis

Liver abscess and sepsis caused by Clostridium perfringens and Klebsiella oxytoca

Gas in the myocardium: a fatal presentation of Clostridium perfringens: a case report

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