Clostridium Perfringens in Dried Milk

Hafez, R.S.; Ahmed, H.F.

doi:10.21608/avmj.1989.188218

Cited by 1 publication

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“…Astragalus membranaceus was used in traditional Chinese medicine 2000 years ago. Astragalus polysaccharide (APS) was extracted from dry roots of Astragalus membranaceus, which was used to regulate the immune system (Hafez et al, 2011), and for vaccine adjuvants (Lian et al, 2014; Liu et al, 2014). Chen et al (2010) demonstrated that APS can improve the immune efficacy of Newcastle disease vaccines in chickens.…”

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confidence: 99%

Effect of in ovo administration of Newcastle disease vaccine conjugated with Astragalus polysaccharide on growth performance, intestinal development, and mucosal immunity in broiler chickens

Xue

Zhang

Wang

et al. 2022

Animal Physiology Nutrition

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This study was conducted to investigate the effect of in ovo administration of a mixture of Astragalus polysaccharide (APS) and Newcastle disease vaccine (NDV) on growth performance, intestinal development, and mucosal immunity in newly hatched chicks. Six hundred specific‐pathogen‐free (SPF) Leghorn fertilised eggs were incubated in a commercial hatchery and divided into four groups: (a) control group injected with 1 ml of 0.9% physiological saline, (b) APS group injected with 1 ml of 1 mg/ml APS solution, and (c) NDV group injected with 1 ml of 104.0 EID50/dose of NDV solution, and (d) APS + NDV group injected with a mixture of 0.5 ml of 2 mg/ml APS plus 0.5 ml 104.0 EID50/dose ND vaccine (NDV) on Day 18.5 of incubation. The results showed that in ovo injection of APS or the mixture of APS and NDV increased the body weight at 1 day (IW) and final weight (FW) at 28 days and increased the feed conversion ratio (FCR) at 1–7, 8–14, 15–21, and 1–28 days of age. The villus height (VH) was increased (p < 0.05), and the crypt depth (CD) was decreased (p < 0.05) in the duodenum compared with the control group. The VH/CD ratios were increased (p < 0.05) in the APS + NDV group compared with controls, NDV group, and APS group on d3. The levels of slgA in washings were increased (p < 0.05) on Days 3, 7, 14, 21, and 28, and the number of IgA+ cells in the duodenum was increased on Days 7, 14, 21, and 28. In addition, the IgA+ cells were promoted from the villus root to the apex in the APS + NDV group. It can be concluded that in ovo administration of NDV conjugated with APS compared with NDV alone may be more effective in promoting growth performance and intestinal mucosal immunity.

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