Clostridium difficile infection precipitating hemolysis in glucose-6-phosphate dehydrogenase-deficient preterm twins causing severe neonatal jaundice

Clostridium difficile in children: Colonisation and disease

“…Numerous studies have substantially linked C. difficile in paediatric patients with various disease states including diarrhoea, 2e10 pseudomembranous colitis 11e19 and reactive arthritis. 20e22 There is also increasing evidence for a potential pathogenic role in other paediatric pathologies including the sudden infant death syndrome, 23 haemolytic uraemic syndrome, 24 haemolysis in glucose-6-phosphate dehydrogenase-deficiency 25 and pneumatosis cystoides intestinalis. 26,27 Some have suggested a link to necrotising enterocolitis (NEC), 28e30 but others including several experimental animal models appear to counter this argument.…”

A Rare Cause of Reversible Renal Hemosiderosis

“…Since 1990, 50 patients with Clostridium perfringens septicemia with hemolysis have been reported [ 11 ]; renal failure was reported in some but there was no mention of biopsy proven renal hemosiderosis. There are also case reports of hemolysis and severe jaundice in G-6-PD-deficient neonates with Clostridium difficile infection [ 12 ]. However, renal involvement and acute kidney injury did not appear to be part of the presentation in infants.…”

Staphylococcus aureus sepsis inducing severe hemolysis in glucose-6-phosphate dehydrogenase (G-6-PD)-deficient preterm infant causing severe neonatal jaundice and kernicterus

“…G-6-PD deficiency is a serious condition and can be associated with acute hemolysis caused by various precipitating factors. In infants, hemolysis can be triggered by maternal ingestion of fava beans, various drugs, topical application of henna, naphthalene or mothballs, triple dye, Chinese herbal remedies, vitamin K3 and infections including Escherichia coli, enteric organisms, Clostridium difficile, Coagulase-negative Staphylococcal infection, Clostridium difficile [7] and catalase-positive organisms [1][2][3][5][6].…”