Clostridium difficile Infection in Hospitalized Children in the United States

Abstract

To evaluate the trend in Clostridium difficile infection (CDI) among hospitalized children in the United States and to evaluate the severity of and risk factors associated with these cases of CDI.

Outcomes of Clostridium difficile infection in pediatric solid organ transplant recipients

“…Our results demonstrate that the incidence of CDI in children with SOT is several times higher than in children without SOT. This finding is consistent with earlier results of an increased risk of CDI in the pediatric SOT population . In this context, our use of nationwide data reiterates the importance of recognizing CDI as an important complication in the post‐transplant setting.…”

Vancomycin Use for Pediatric Clostridium difficile Infection Is Increasing and Associated with Specific Patient Characteristics

“…Payer status was noted to be associated with vancomycin use on univariate analysis; however, due to strong colinearity with race, did not enter into our final model or fully explain the variation in vancomycin use on the basis of race. One recent study demonstrated an increase in risk of CDI among white children, although black children had an increased risk of death, longer hospital stay, and higher hospitalization charges (3). Despite the suggestion that black children with CDI have worse outcomes, in our study they were significantly less likely to receive vancomycin.…”

Community-acquired Clostridium difficile infection in children: A retrospective study

“…Similar results have been reported by other large multicentre cohorts [14][15][16]. Moreover, there is evidence to suggest that a large proportion of paediatric CDI are community-acquired infections and that many of these cases lack the typical risk pattern associated with exposure to antimicrobial drugs [4].…”