Clostridium difficile infection: a Serbian single-center experience

Korać, Marija; Milošević, Ivana; Marković, Miroslav; Popović, Nataša; Ilić, Milena; Marković, Aleksandar; Nikolić, Jelena; Jevtović, Djordje

doi:10.3855/jidc.5060

Cited by 8 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reports on C. difficile in Serbia are scarce [3][4][5][6][7][8][9][10][11]. Since 2008, the University Hospital for Infectious and Tropical Diseases of the Clinical Center of Serbia in Belgrade has been the central Serbian institution for the treatment of patients with CDI [3]. Among 510 patients treated in this hospital from 2008 to 2013, the reported recurrence and case fatality rates were 8.4% and 6.3%, respectively [3].…”

Section: Introductionmentioning

confidence: 99%

“…Since 2008, the University Hospital for Infectious and Tropical Diseases of the Clinical Center of Serbia in Belgrade has been the central Serbian institution for the treatment of patients with CDI [3]. Among 510 patients treated in this hospital from 2008 to 2013, the reported recurrence and case fatality rates were 8.4% and 6.3%, respectively [3]. More severe forms of CDI and a notably higher recurrence rate were observed among patients treated in the same hospital from 2013 to 2015 [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

et al. 2020

View full text Add to dashboard Cite

Background: The global epidemic of nosocomial diarrhea caused by Clostridioides (Clostridium) difficile started in 2000, with high mortality rates and emergence of a new hypervirulent strain NAP1/BI/027. The aim of this study was to assess the presence of ribotype 027 and other C. difficile ribotypes in a Serbian University Hospital, compare the temporal variability of ribotypes 3 years apart, as well as to compare clinical, demographic and laboratory characteristics and disease outcome among patients infected with 027 and non-027 ribotype. This was a prospective observational cohort study addressing 4-month intervals during 2014/2015 and 2017/2018. Results: Ribotyping was performed in 64 non-duplicate C. difficile strains. Ribotype 027 was the most prevalent, and was detected in 53 (82.8%) patients (43/45 and 10/19 patients in 2014-2015 and 2017/2018, respectively). Other detected ribotypes were 001/072 in 4 (6.3%), 002 in 4 (6.3%), 014/020 in 2 (3.1%) and 176 in 1 (1.5%) patient. The percentage of the patients infected with ribotype 027 significantly decreased during the 3-year period, from 95.6 to 52.6% (p < 0.001). Ribotype 027 infection was associated with fluoroquinolone treatment more frequently than infection with other ribotypes [33 (62.3%) vs. 2 (18.2%), p = 0.010)]. A severe C. difficile infection was diagnosed more often in patients with the detected ribotype 027 compared to those infected with non-027 ribotypes (p = 0.006). No significant difference in the mortality and recurrence rates was found between the patients infected with ribotype 027 and those infected with other ribotypes [10/53 (18.8%) vs. 2/11 (18.2%), p = 0.708, and 10/35 (28.6%) vs. 0/2 (0%), p = 1.000, respectively]. Conclusion: Clostridium difficile ribotype 027 was the most prevalent ribotype among patients in a large Serbian hospital, but there is a clear decreasing trend.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The reports on C. difficile in Serbia are scarce (3)(4)(5)(6)(7)(8)(9)(10)(11). Since 2008, the University Hospital for Infectious and Tropical Diseases of the Clinical Center of Serbia in Belgrade has been the central Serbian institution for the treatment of patients with CDI (3).…”

Section: Introductionmentioning

confidence: 99%

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Korać

Rupnik

Nikolić

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The global epidemic of nosocomial diarrhea caused by Clostridioides (Clostridium) difficile started in 2000, with high mortality rates and emergence of a new hypervirulent strain NAP1/BI/027. The aim of this study was to assess the presence of ribotype 027 and other C. difficile ribotypes in a Serbian University Hospital, compare the temporal variability of ribotypes three years apart, as well as to compare clinical, demographic and laboratory characteristics and disease outcome among patients infected with 027 and non-027 ribotype. This was a prospective observational cohort study addressing four-month intervals during 2014/2015 and 2017/2018. Results: Ribotyping was performed in 64 non-duplicate C. difficile strains. Ribotype 027 was the most prevalent, and was detected in 53 (82.8%) patients (43/45 and 10/19 patients in 2014-2015 and 2017/2018, respectively). Other detected ribotypes were 001/072 in 4 (6,3%), 002 in 4 (6,3%), 014/020 in 2 (3,1%) and 176 in 1 (1,5%) patient. The percentage of the patients infected with ribotype 027 significantly decreased during the three-year period, from 95.6% to 52.6% (p<0.001). Ribotype 027 infection was associated with fluoroquinolone treatment more frequently than infection with other ribotypes [33 (62.3%) vs. 2 (18.2%), p= 0.010)]. A severe C. difficile infection was diagnosed more often in patients with the detected ribotype 027 compared to those infected with non-027 ribotypes (p=0.006). No significant difference in the mortality and recurrence rates was found between the patients infected with ribotype 027 and those infected with other ribotypes [10/53 (18.8%) vs. 2/11 (18.2%), p=0.708, and 10/35 (28.6%) vs. 0/2 (0%), p=1.000, respectively].Conclusion: C. difficile ribotype 027 was the most prevalent ribotype among patients in a large Serbian hospital, but there is a clear decreasing trend.

show abstract

“…The reports on C. difficile in Serbia are scarce (3)(4)(5)(6)(7)(8)(9)(10)(11). Since 2008, University Hospital for Infectious and Tropical Diseases, Clinical Center of Serbia in Belgrade has been central Serbian institution for the treatment of patients with CDI (3).…”

Section: Introductionmentioning

confidence: 99%

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Korać

Rupnik

Nikolić

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The global epidemic of nosocomial diarrhea caused by Clostridioides ( Clostridium) difficile started in 2003, with high mortality rates and emergence of a new hypervirulent strain NAP1/BI/027. The aim of this study was to assess the presence of ribotype 027 and other C. difficile ribotypes in a Serbian University Hospital, to compare the temporal variability of ribotypes three years apart, as well as to compare clinical, demographic and laboratory characteristics and disease outcome among patients infected with 027 and non-027 ribotype. This was a prospective observational study addressing four months time intervals during 2014/2015 and 2017/2018. Results: Ribotyping was performed in 64 non-duplicate C.difficile strains. Ribotype 027 was the most prevalent, and was detected in 53 (82.8%) patients (43/45 and 10/19 patients in 2014-2015 and 2017/2018, respectively). Other detected ribotypes were 001/072 in 4 (6,3%), 002 in 4 (6,3%), 014/020 in 2 (3,1%) and 176 in 1 (1,5%) patient. The percentage of patients infected with ribotype 027 significantly decreased during the three-year period, from 95.6% to 52.6% ( p <0.001). Ribotype 027 infection was associated with fluoroquinolone treatment more frequently than infection with other ribotypes [33 (62.3%) vs. 2 (18.2%), p= 0.010)]. Severe C.difficile infection was diagnosed more often in patients with detected ribotype 027 compared to those infected with non-027 ribotypes (p=0.006). No significant difference in the mortality and recurrence rates was found between patients infected with ribotype 027 and those infected with other ribotypes [10/53 (18.8%) vs. 2/11 (18.2%), p=0.708, and 10/35 (28.6%) vs. 0/2 (0%), p=1.000, respectively]. Conclusion: C. difficile ribotype 027 was the most prevalent ribotype among patients in a large Serbian hospital, but there is a clear decreasing trend.

show abstract

Clostridium difficile infection: a Serbian single-center experience

Cited by 8 publications

References 15 publications

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Clostridioides difficile ribotype distribution in a large teaching hospital in Serbia

Contact Info

Product

Resources

About