Clostridium difficile-associated disease: A primary clinical evaluation of elderly patients in a geriatric hospital

Molecular, microbiological and clinical characterization of Clostridium difficile isolates from tertiary care hospitals in Colombia

“…Most of the risk factors frequently reported in several studies for the development CDI include, number and type of antibiotics, patients older than 65 years [ 32 , 33 ], length of stay (LOS) at the hospital [ 34 , 35 ], nasogastric tube insertion [ 36 ], and various comorbidities or preexisting conditions [ 23 , 34 , 37 , 38 ]; nonetheless, in this study, these variables did not show significant associations.…”

“…For instance, patients at the orthopedic service, subjected to surgery and to extend antibiotic therapies, are most likely to develop CDI; also steroids were a protector factor. Similarly, a previous study conducted in a geriatric hospital as well reported that steroids were more frequently used in patients without CDI in comparison with those eldery patients who developed CDI [ 37 ]. These results contrast with those of investigations that indicate that steroids are potentially useful markers for CDI mortality prediction [ 38 , 39 ].…”

Acute Clostridioides difficile Infection in Hospitalized Persons Aged 75 and Older: 30-Day Prognosis and Risk Factors for Mortality

“…This rate is lower than 30-day mortality rates reported in literature, which were between 16.5% and 32.2% in patients older than 65 and 80 years, respectively. 21,27,28 Organ failure, defined as relying on intravenous loop diuretics, need for oxygen, or rise in serum creatinine level !50% of the premorbid level, was the most predictive parameter of short-term mortality (HR 3.04, CI 95% 1.40-6.59). Among these criteria, renal failure occurring during the course of CDI illness and relying on rise in serum creatinine level !1.5 times the premorbid level was the most relevant ( Table 2).…”

Clostridium difficile infection in hospitalized octogenarian patients

“…Most of the studies evaluating CDI in older adults included patients aged between 65 and 80 years, and just a few have assessed CDI in the very elderly (i.e. ≥80 years) . Life expectancy has increased over the past years in most countries, and the number of older adults with a high risk for CDI is also increasing .…”