Clostridium difficile-associated diarrhea from a general hospital in Argentina

Legaria, María C.; Lumelsky, G.; Rosetti, S

doi:10.1016/s1075-9964(03)00088-x

Cited by 30 publications

(21 citation statements)

References 17 publications

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“…In Argentina, 104 consecutive stool samples from 87 patients with diarrhea were screened for toxigenic CD between April 2000 and April 2001. 31,33 The study reported that 38.5% of the samples and 36.8% of the patients were positive for CD. Another study performed in a 200-bed general hospital in Buenos Aires 35 showed incidence rates of CDI ranging from 37 to 84 per 10,000 admissions between years 2000 and 2005.…”

Section: Discussionmentioning

confidence: 98%

Epidemiology of Clostridium difficile: a hospital-based descriptive study in Argentina and Mexico

Lopardo

Morfín‐Otero

Moran-Vazquez

et al. 2015

The Brazilian Journal of Infectious Diseases

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A prospective study was conducted in four tertiary hospitals in Argentina and Mexico in order to describe the occurrence of Clostridium difficile infection (CDI) in these settings. The objective was to evaluate the incidence of CDI in at-risk populations in Argentina (one center) and Mexico (three centers) and to further explore potential study sites for vaccine development in this region. A prospective, descriptive, CDI surveillance study was conducted among hospitalized patients aged ≥40 years who had received ≥48h of antibiotic treatment. Stool samples were collected from those with diarrhea within 30 days after starting antibiotics and analyzed for toxins A and B by ELISA, and positive samples were further tested by toxinogenic culture and restriction endonuclease analysis type assay. Overall, 466 patients were enrolled (193 in Argentina and 273 in Mexico) of whom 414 completed the follow-up. Of these, 15/414 (3.6%) experienced CDI episodes occurring on average 18.1 days after admission to hospital and 15.9 days after the end of antibiotics treatment. The incidence rate of CDI was 3.1 (95% CI 1.7-5.2) per 1000 patient-days during hospitalization, and 1.1 (95% CI 0.6-1.8) per 1000 patient-days during the 30-day follow-up period. This study highlighted the need for further evaluation of the burden of CDI in both countries, including the cases occurring after discharge from hospital.

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Section: Discussionmentioning

confidence: 98%

Epidemiology of Clostridium difficile: a hospital-based descriptive study in Argentina and Mexico

Lopardo

Morfín‐Otero

Moran-Vazquez

et al. 2015

The Brazilian Journal of Infectious Diseases

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“…In a 1-year study conducted with symptomatic patients from a general hospital, Legaria et al (2003) observed a higher frequency of CDAD, which was detected in 36.8 % (32/87) of the patients analysed. Again, the expected risk groups for CDAD development were observed.…”

Section: Argentinamentioning

confidence: 88%

Clostridium difficile: a problem of concern in developed countries and still a mystery in Latin America

Balassiano

Yates

Domingues

et al. 2012

Journal of Medical Microbiology

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“…The prevalence of C. difficile A-/B+ strain is higher in other parts of the World, such as Japan (39%), Korea (43%), and Israel (56%). These strains are most dominant in Argentina (97.9%), regarding to total number of toxigenic isolates (6,11,14,22,23 According to available data from referent literature, until the present day, the investigation of CDAD has not been conducted in Serbia, and this is the first research considering of this health problem.…”

Section: Introductionmentioning

confidence: 99%

Clinical importance and representation of toxigenic and non-toxigenic Clostridium difficile cultivated from stool samples of hospitalized patients

Stojanović¹,

Kocić²,

Stojanović³

et al. 2012

Braz. J. Microbiol.

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The aim of this study was to fortify the clinical importance and representation of toxigenic and non-toxigenic Clostridium difficile isolated from stool samples of hospitalized patients. This survey included 80 hospitalized patients with diarrhea and positive findings of Clostridium difficile in stool samples, and 100 hospitalized patients with formed stool as a control group.Bacteriological examination of a stool samples was conducted using standard microbiological methods. Stool sample were inoculated directly on nutrient media for bacterial cultivation (blood agar using 5% sheep blood, This research confirmed clinical importance of toxigenic Clostridium difficile found in liquid stool samples of hospitalized patient, and the possibility of asymptomatic carriage in 2% of patients with formed stool.

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Clostridium difficile-associated diarrhea from a general hospital in Argentina

Cited by 30 publications

References 17 publications

Epidemiology of Clostridium difficile: a hospital-based descriptive study in Argentina and Mexico

Epidemiology of Clostridium difficile: a hospital-based descriptive study in Argentina and Mexico

Clostridium difficile: a problem of concern in developed countries and still a mystery in Latin America

Clinical importance and representation of toxigenic and non-toxigenic Clostridium difficile cultivated from stool samples of hospitalized patients

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