Clostridium butyricum miyairi 588 has preventive effects on chronic social defeat stress-induced depressive-like behaviour and modulates microglial activation in mice

Tian, Tian; Xu, Bing; Qin, Yinhua; Fan, Liancheng; Chen, Jianjun; Zheng, Peng; Gong, Xue; Wang, Haiyang; Bai, Mengge; Pu, Juncai; Lu, Jian; Wei, Zhou; Zhao, Libo; Yang, Deyu; Xie, Peng

doi:10.1016/j.bbrc.2019.06.053

Cited by 54 publications

(42 citation statements)

References 31 publications

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“…We did not include diet in the current study, which was a limitation. In a murine study it has been reported that Clostridium butyricum can modulate in ammatory factors and microglial activation to prevent depression-like behavior [24], which also supports our ndings. Butyrate-producing Coprococcus bacteria are consistently associated with higher quality of life indicators.…”

Section: Discussionsupporting

confidence: 91%

Effect of Gut Microbiotas Diversity During 32-39 Weeks of Gestation on Postpartum Depression

Zhang¹,

Gan²,

Yang³

et al. 2020

Preprint

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Background: Patients with major depression are accompanied by intestinal flora flocculation; however, the relationship between the composition of gut microbiota in pregnancy and postpartum depression (PPD) has not been established. In this study we determined the effect of the gut microbiota in pregnant women during 32-39 weeks of gestation on PPD.Methods: Participants (n = 74) were enrolled between 2016–2017 from the Guangzhou Women and Children’s Medical Centre (GWCMC). Stool samples were collected during 32-39 weeks of gestation, and the relative abundance of fecal microbiota was characterized by 16S rRNA sequencing. The parturients completed the mainland Chinese version of the Edinburgh Postnatal Depression Scale (EPDS) 42 days postpartum to detect PPD. The linear discriminant analysis (LDA) effect size (LEfSe) method was used to identify bacterial population differences between the PPD and control groups.Results: The top three bacteria phyla in the PPD and control groups were Firmicutes, Bacteroidetes, and Actinobacteria. Compared with healthy pregnant women, the alpha diversity index of the PPD group was lower. Beta diversity analysis was performed by PCoA showing that no significant differences in bacterial community structures between the two groups (R2 = 0.013, P = 0.549). The composition of gut microbiota during 32-39 weeks of gestation of the two groups was different. At the genera level, Acinetobacter, Plesiomonas, Enterococcus, Olsenella, Alloscardovia, and Anaerotruncus were increased in the PPD group, while Lactococcus, Adlercreutzia, Clostridium, Coprococcus, and unclassified-Clostridiales were decreased. At the species level, hypermegale, uli, casseliflavus, and hathewayi were increased in the PPD group, and celatum was increased in the control group.Conclusions: During 32-39 weeks of gestation, a reduction in diversity of gut microbiota and anti-inflammatory bacteria, and an increase in opportunistic pathogenic bacteria are more likely to cause PPD.

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Section: Discussionsupporting

confidence: 91%

Effect of Gut Microbiotas Diversity During 32-39 Weeks of Gestation on Postpartum Depression

Zhang¹,

Gan²,

Yang³

et al. 2020

Preprint

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“…Indeed, the pre-existing levels of Blautia and Ruminococcae correlated with the metabolic outcomes of a Bifidobacterium-targeting prebiotic intervention in obese patients (40). Furthermore, Blautia has been found to be the only genus to be enriched in depressionmodel rats (41) and both Blautia and Ruminococcae correlated with stress-related depression-like behaviour in mice (42). In summary, variations in Blautia and Ruminococcus 2 abundance might relate to stress-induced modulation of DMN connectivity.…”

Section: Discussionmentioning

confidence: 92%

Multivariate associative patterns between the gut microbiota and large-scale brain network connectivity

Kohn

Llera

Beckmann

et al. 2020

Preprint

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Research on the gut-brain axis has accelerated substantially over the course of the last years. Many reviews have outlined the important implications of understanding the relation of the gut microbiota with human brain function and behavior. One substantial drawback in integrating gut microbiome and brain data is the lack of integrative multivariate approaches that enable capturing variance in both modalities simultaneously. To address this issue, we applied a linked independent component analysis (LICA) to microbiota and brain connectivity data. We analyzed data from 58 healthy females (mean age=21.5 years). Magnetic Resonance Imaging data were acquired using resting state functional imaging data. The assessment of gut microbial composition from feces was based on sequencing of the V4 16S rRNA gene region. We used the LICA model to simultaneously factorize the subjects' large-scale brain networks and microbiome relative abundance data into 10 independent components of spatial and abundance variation. LICA decomposition resulted in four components with non-marginal contribution of the microbiota data. The default mode network featured strongly in three components, whereas the two-lateralized fronto-parietal attention networks contributed to one component. The executive-control (with the default mode) network was associated to another component. We found the abundance of Prevotella genus was associated to the strength of expression of all networks, whereas Bifidobacterium was associated with the default mode and frontoparietal-attention networks. We provide the first exploratory evidence for multivariate associative patterns between the gut microbiota and brain network connectivity in healthy humans, taking into account the complexity of both systems.

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“…A study conducted on a group of healthy students showed that, following an extremely stressful period, fewer species of Lactobacillus were present in the stool. Moreover, a condition of chronic stress induced in mice reduced Lactobacillus, Eubacterium rectale, Lachnospira, Butyricicoccus, Sutterella, and Faecalibacteria and increased the number of pathogenic species Clostridium, Proteobacteria, Actinobacteria, and Enterobacteriaceae (Tian et al, 2019). An important and well-organized experimental work revealed that an altered composition of the intestinal microbiota induced in mice through the use of massive doses of antibiotics in a period corresponding to the early adolescence of the animals, led to alterations in cognitive function and the appearance of symptoms related to anxiety and depression (Zeraati et al, 2019).…”

Section: Anxiety and Depressionmentioning

confidence: 99%

The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders

et al. 2021

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Different bacterial families colonize most mucosal tissues in the human organism such as the skin, mouth, vagina, respiratory, and gastrointestinal districts. In particular, the mammalian intestine hosts a microbial community of between 1,000 and 1,500 bacterial species, collectively called “microbiota.” Co-metabolism between the microbiota and the host system is generated and the symbiotic relationship is mutually beneficial. The balance that is achieved between the microbiota and the host organism is fundamental to the organization of the immune system. Scientific studies have highlighted a direct correlation between the intestinal microbiota and the brain, establishing the existence of the gut microbiota–brain axis. Based on this theory, the microbiota acts on the development, physiology, and cognitive functions of the brain, although the mechanisms involved have not yet been fully interpreted. Similarly, a close relationship between alteration of the intestinal microbiota and the onset of several neurological pathologies has been highlighted. This review aims to point out current knowledge as can be found in literature regarding the connection between intestinal dysbiosis and the onset of particular neurological pathologies such as anxiety and depression, autism spectrum disorder, and multiple sclerosis. These disorders have always been considered to be a consequence of neuronal alteration, but in this review, we hypothesize that these alterations may be non-neuronal in origin, and consider the idea that the composition of the microbiota could be directly involved. In this direction, the following two key points will be highlighted: (1) the direct cross-talk that comes about between neurons and gut microbiota, and (2) the degree of impact of the microbiota on the brain. Could we consider the microbiota a valuable target for reducing or modulating the incidence of certain neurological diseases?

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Clostridium butyricum miyairi 588 has preventive effects on chronic social defeat stress-induced depressive-like behaviour and modulates microglial activation in mice

Cited by 54 publications

References 31 publications

Effect of Gut Microbiotas Diversity During 32-39 Weeks of Gestation on Postpartum Depression

Effect of Gut Microbiotas Diversity During 32-39 Weeks of Gestation on Postpartum Depression

Multivariate associative patterns between the gut microbiota and large-scale brain network connectivity

The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders

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