Clostridioides difficile infection in a patient with immunoglobulin A vasculitis: a triggering factor or a rare complication of the disease? A case-based review

Kounatidis, Dimitris; Vadiaka, Maria; Kouvidou, Charikleia; Sampaziotis, Dimitrios; Skourtis, Alexandros; Panagopoulos, Fotis; Konstantinou, Fotis

doi:10.1007/s00296-020-04586-5

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Other uncommon complications, such as malabsorption and exudative enteropathy did not occur in our cohort. Interestingly, a recent study has highlighted a possible correlation between GI symptoms and Clostridium difficile infection [ 17 ]; however, in our cohort we did not find any case of Clostridium infection.…”

Section: Discussioncontrasting

confidence: 87%

Epidemiological and clinical aspects of immunoglobulin A vasculitis in childhood: a retrospective cohort study

et al. 2021

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Background A retrospective study was conducted in order to investigate and describe the characteristics of Immunoglobulin A vasculitis (IgAV), previously known as Henoch-Schӧnlein purpura, in the paediatric population of a community-based healthcare delivery system in the Italian region of Abruzzo. Methods This is a population-based retrospective chart review of the diagnosis of IgAV in children ages 0 to 18, admitted to the Department of Paediatrics of Chieti and Pescara between 1 January 2000 and 31 December 2016. All children enrolled presented with clinical symptoms and laboratory findings and met the EULAR/PRINTO/PRES 2008 criteria. Results Two-hundred-eight children met the criteria for IgAV, with the highest incidence reported among children below 7-years of age. A correlation with recent infections was found in 64% of the cohort; the onset was more frequently during the winter and fall. Purpura had a diffuse distribution in the majority of patients; joint impairment was the second most frequent symptom (43%), whereas the gastrointestinal tract was involved in 28% of patients. Conclusions Hereby, we confirm the relative benignity of IgAV in a cohort of Italian children; with regards to renal involvement, we report a better outcome compared to other studies. However, despite the low rate of renal disease, we observed a wide use of corticosteroids, especially for the treatment of persistent purpura.

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Section: Discussioncontrasting

confidence: 87%

Epidemiological and clinical aspects of immunoglobulin A vasculitis in childhood: a retrospective cohort study

et al. 2021

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“…Consistently, many types of bacteria and viruses are thought to be associated with the pathogenesis of IgA vasculitis. The representative causative pathogens are Streptococcus [ 22 , 23 , 24 ], S. aureus [ 25 , 26 , 27 , 28 ], Helicobacter pylori [ 29 , 30 ], varicella-zoster virus [ 31 , 32 ], hepatitis virus [ 33 ], Parvovirus [ 34 , 35 ], human immunodeficiency virus [ 36 ], cytomegalovirus [ 37 ], and Clostridium difficile [ 38 ]. Therefore, these microorganisms are triggers for the development of IgA vasculitis.…”

Section: Triggers and Pathogenesis Of Iga Vasculitismentioning

confidence: 99%

IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

Sugino

Sawada

Nakamura

2021

IJMS

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IgA, previously called Henoch-Schönlein vasculitis, is an essential immune component that drives the host immune response to the external environment. As IgA has the unique characteristic of a flexible response to broad types of microorganisms, it sometimes causes an autoreactive response in the host human body. IgA vasculitis and related organ dysfunction are representative IgA-mediated autoimmune diseases; bacterial and viral infections often trigger IgA vasculitis. Recent drug developments and the presence of COVID-19 have revealed that these agents can also trigger IgA vasculitis. These findings provide a novel understanding of the pathogenesis of IgA vasculitis. In this review, we focus on the characteristics of IgA and symptoms of IgA vasculitis and other organ dysfunction. We also mention the therapeutic approach, biomarkers, novel triggers for IgA vasculitis, and epigenetic modifications in patients with IgA vasculitis.

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“…However, it is thought to occur secondary to upper respiratory tract infections, drugs, vaccines, or malignancies [5]. Some pathogens known to be associated with IgAV are Streptococcus [6], S. aureus [7], Helicobacter pylori [8], varicellazoster virus [9], hepatitis virus [10], Parvovirus [11], human immunodeficiency virus [12], cytomegalovirus [13], and Clostridium difficile [14]. Due to the accumulation of IgA after an infection in small vessels and the presence of proinflammatory cytokines in the acute stage; recognized as postinfectious immune-mediated small vessel vasculitis [15].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of the Pandemic Period on Henoch-Schönlein Purpura

Çoban,

Ulu,

Sözeri

2024

Preprint

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Background Immunoglobulin A vasculitis is a vasculitis that occurs after a triggering infection and progresses with different clinical manifestations. Recent studies have shown an association between coronavirus disease and IgA vasculitis in children. In this study, it was aimed to evaluate the effect of the pandemic period on the course of IgA vasculitis. Methods Clinical data of 224 patients who were newly diagnosed with IgA vasculitis were retrospectively reviewed and grouped into prepandemic, pandemic and postpandemic periods. The clinical data of the patients in these periods were compared. Results In the prepandemic period, pandemic period and postpandemic period the number of patients were 75 [33.5%], 21 [9.4%] and 128 [57.1%], respectively. There was no significant difference between the periods in terms of isolated skin/systemic, gastrointestinal system and renal involvement [p>0.05]. Patients admitted with the diagnosis of IgA vasculitis in the prepandemic, pandemic and postpandemic periods comprised 0.5%, 0.2% and 0.3% of all patients, respectively. Conclusion While the number of patients admitted during the pandemic period decreased by 50%, it increased by 50% in the postpandemic period. It was thought that the reducing spread of viral infections with isolation measures may contribute to the decrease in IgA vasculitis cases.

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Clostridioides difficile infection in a patient with immunoglobulin A vasculitis: a triggering factor or a rare complication of the disease? A case-based review

Cited by 4 publications

References 15 publications

Epidemiological and clinical aspects of immunoglobulin A vasculitis in childhood: a retrospective cohort study

Epidemiological and clinical aspects of immunoglobulin A vasculitis in childhood: a retrospective cohort study

IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

Evaluation of the Effect of the Pandemic Period on Henoch-Schönlein Purpura

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