Clostridiales are predominant microbes that mediate psychiatric disorders

Li, Jingjing; Ma, Yunlong; Zhaorigetu, Bao; Gui, Xiaohua; Li, Andria N.; Yang, Zhongli; Li, Ming D.

doi:10.1016/j.jpsychires.2020.07.018

Cited by 36 publications

(33 citation statements)

References 45 publications

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“…The current TBI-related changes to overall diversity appear primarily due to decreased relative abundance of Firmicutes (Figure 6A). These Firmicutes effects were driven by changes in class Clostridia and order Clostridiales (Figure 6D and F), an order affecting amino acid metabolism and linked to psychiatric dysfunction (Li et al, 2020). However, our high intratime point variability (reflected by main effects of collection time on α diversity and phyla composition) suggests that researchers should consider expanding collection time points and using caution when interpreting data with low taxonomic levels, which may naturally fluctuate across measurements.…”

Section: Discussionmentioning

confidence: 99%

Acute gut microbiome changes after traumatic brain injury are associated with chronic deficits in decision-making and impulsivity in male rats.

Frankot¹,

O'Hearn²,

Blancke³

et al. 2023

Behavioral Neuroscience

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The mechanisms underlying chronic psychiatric-like impairments after traumatic brain injury (TBI) are currently unknown. The goal of the present study was to assess the role of diet and the gut microbiome in psychiatric symptoms after TBI. Rats were randomly assigned to receive a high-fat diet (HFD) or caloriematched low-fat diet (LFD). After 2 weeks of free access, rats began training on the rodent gambling task (RGT), a measure of risky decision-making and motor impulsivity. After training, rats received a bilateral frontal TBI or a sham procedure and continued postinjury testing for 10 weeks. Fecal samples were collected before injury and 3-, 30-, and 60 days postinjury to evaluate the gut microbiome. HFD altered the microbiome, but ultimately had low-magnitude effects on behavior and did not modify functional outcomes after TBI. Injury-induced functional deficits were far more robust; TBI substantially decreased optimal choice and increased suboptimal choice and motor impulsivity on the RGT. TBI also affected the microbiome, and a model comparison approach revealed that bacterial diversity measured 3 days postinjury was predictive of chronic psychiatric-like deficits on the RGT. A functional metagenomic analysis identified changes to dopamine and serotonin synthesis pathways as a potential candidate mechanism. Thus, the gut may be a potential acute treatment target for psychiatric symptoms after TBI, as well as a biomarker for injury and deficit severity. However, further research will be needed to confirm and extend these findings.

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Section: Discussionmentioning

confidence: 99%

Acute gut microbiome changes after traumatic brain injury are associated with chronic deficits in decision-making and impulsivity in male rats.

Frankot¹,

O'Hearn²,

Blancke³

et al. 2023

Behavioral Neuroscience

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show abstract

“…Clostridiales are known to degrade branched chain amino acids (BCAAs), which share brain transporters with tryptophan. It is plausible that Clostridiales depletion, by increasing circulating concentrations of BCAA, could decrease brain tryptophan uptake and serotonin production, thus impacting on psychopathological dimensions of SCZ [ 43 ]. The gut microbiota of patients affected by SCZ was also lacking bacteria of the genus Haemophilus , which were overrepresented in HC.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics

et al. 2021

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The gut microbiota is constituted by more than 40,000 bacterial species involved in key processes including high order brain functions. Altered composition of gut microbiota has been implicated in psychiatric disorders and in modulating the efficacy and safety of psychotropic medications. In this work we characterized the composition of the gut microbiota in 38 patients with schizophrenia (SCZ) and 20 healthy controls (HC), and tested if SCZ patients with different response to antipsychotics (18 patients with treatment resistant schizophrenia (TRS), and 20 responders (R)) had specific patterns of gut microbiota composition associated with different response to antipsychotics. Moreover, we also tested if patients treated with typical antipsychotics (n=20) presented significant differences when compared to patients treated with atypical antipsychotics (n=31). Our findings showed the presence of distinct composition of gut microbiota in SCZ versus HC, with several bacteria at the different taxonomic levels only present in either one group or the other. Similar findings were observed also depending on treatment response and exposure to diverse classes of antipsychotics. Our results suggest that composition of gut microbiota could constitute a biosignatures of SCZ and TRS.

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“…Clostridia are the most common fermenters of amino acids found in the gut ( Young et al., 2020 ). A recent study revealed that depletion of some Clostridiales was associated with dysfunction in amino acid metabolism and carbohydrate metabolism ( Li et al., 2020a ). Clostridium , as the core gut microbial genus, is closely related to carbohydrate metabolism.…”

Section: Discussionmentioning

confidence: 99%

Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats

Wang

et al. 2021

Front. Cell. Infect. Microbiol.

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Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investigated. Here, we developed a rat model of active smoking and characterized the effects of active smoking on the microbiota within multiple regions along the digestive tract. Blood glucose and some metabolic factors levels, the microbial diversity and composition, relative abundances of taxa, bacterial network correlations and predictive functional profiles were compared between the control group and active smoking group. We found that active smoking induced hyperglycemia and significant reductions in serum insulin and leptin levels. Active smoking induced region-specific shifts in microbiota structure, composition, network correlation and metabolism function along the digestive tract. Our results demonstrated that active smoking resulted in a reduced abundance of some potentially beneficial genera (i.e. Clostridium, Turicibacter) and increased abundance of potentially harmful genera (i.e. Desulfovibrio, Bilophila). Functional prediction suggested that amino acid, lipid, propanoate metabolism function could be impaired and antioxidant activity may be triggered. Active smoking may be an overlooked risk to health through its potential effects on the digestive tract microbiota, which is involved in the cause and severity of an array of chronic diseases.

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Clostridiales are predominant microbes that mediate psychiatric disorders

Cited by 36 publications

References 45 publications

Acute gut microbiome changes after traumatic brain injury are associated with chronic deficits in decision-making and impulsivity in male rats.

Acute gut microbiome changes after traumatic brain injury are associated with chronic deficits in decision-making and impulsivity in male rats.

Involvement of Gut Microbiota in Schizophrenia and Treatment Resistance to Antipsychotics

Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats

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