Closing the loop: Novel quantitative fMRI approach for manipulation of the sensorimotor loop in tremor

Sharifi, Sarvi; Luft, Frauke; Boer, Lieke de; Buijink, A. W. G.; Mugge, Winfred; Schouten, Alfred C.; Heida, Tjitske; Bour, L.J.; Rootselaar, Anne-Fleur van

doi:10.1016/j.neuroimage.2022.119554

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…Several meta-analyses have concluded that functional brain networks are quantitatively altered in epilepsy and that these changes are potential biomarkers for diagnosis and treatment (Dharan et al, 2021; Slinger et al, 2022). While closed-loop pathway analysis has been applied to examine changes in brain networks associated with motor dysfunction (Shari et al, 2022), this is the rst study to apply closed-loop pathway analysis of rs-fMRI data to epilepsy at the whole-brain level, and further to examine the associations of these pathway changes with comorbid anxiety, depression, and cognitive dysfunction. Indeed, multiple closed-loop pathways involving structures within the frontal, parietal, and occipital lobes were altered in MRI − -DRE patients, and the magnitudes of these alterations in occipital lobe closed-loop pathways were associated with clinical indicators of emotional and cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Identification of abnormal closed-loop pathways in patients with MRI-negative drug-resistant epilepsy

Bu,

Yin,

Ren

et al. 2023

Preprint

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To identify abnormal changes in closed-loop pathways among magnetic resonance imaging-negative drug-resistant epilepsy (MRI−-DRE) patients and to examine the associations of these abnormalities with emotional and cognitive impairments. A total of 26 patients with MRI−-DRE and 26 healthy controls (HCs) were included in this study. Causal brain networks and temporal-lag brain networks were constructed from rs-fMRI data, and the Johnson algorithm was used to identify stable closed-loop pathways. Abnormal closed-loop pathways in the MRI−-DRE group were identified by comparison with HCs, and associations with indicators of cognitive and emotional impairments were examined using Pearson correlation analysis. The results reveal that the abnormal stable closed-loop pathways were distributed across frontal, parietal, and occipital lobes, and included altered FC values both within and between cerebral hemispheres. Four abnormal closed-loop pathways in the occipital lobe were associated with emotional and cognitive impairments. These abnormalities may serve as biomarkers for diagnosis and guidance of individualized treatments for MRI−-DRE.

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Section: Discussionmentioning

confidence: 99%

Identification of abnormal closed-loop pathways in patients with MRI-negative drug-resistant epilepsy

Bu,

Yin,

Ren

et al. 2023

Preprint

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“…The emergence of fMRI techniques for brain mapping, based on the principle of blood-oxygen-level-dependent (BOLD) contrast changes, plays a valuable role in understanding movement disorders [ 36 ]. Investigators have used fMRI alone [ 37 ] or combined with electromyography [ 38 , 39 , 40 ] to study possible cerebral activation patterns in patients with essential tremor. Using resting fMRI, Wang et al observed abnormal brain activities in the cerebello-cortical regions in hand and head tremor patients but in the cerebellar area in patients without head tremor [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Mapping Pharmacologically Evoked Neurovascular Activation and Its Suppression in a Rat Model of Tremor Using Functional Ultrasound: A Feasibility Study

Nayak

Lee

Korani

et al. 2023

Sensors

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Functional ultrasound (fUS), an emerging hemodynamic-based functional neuroimaging technique, is especially suited to probe brain activity and primarily used in animal models. Increasing use of pharmacological models for essential tremor extends new research to the utilization of fUS imaging in such models. Harmaline-induced tremor is an easily provoked model for the development of new therapies for essential tremor (ET). Furthermore, harmaline-induced tremor can be suppressed by the same classic medications used for essential tremor, which leads to the utilization of this model for preclinical testing. However, changes in local cerebral activities under the effect of tremorgenic doses of harmaline have not been completely investigated. In this study, we explored the feasibility of fUS imaging for visualization of cerebral activation and deactivation associated with harmaline-induced tremor and tremor-suppressing effects of propranolol. The spatial resolution of fUS using a high frame rate imaging enabled us to visualize time-locked and site-specific changes in cerebral blood flow associated with harmaline-evoked tremor. Intraperitoneal administration of harmaline generated significant neural activity changes in the primary motor cortex and ventrolateral thalamus (VL Thal) regions during tremor and then gradually returned to baseline level as tremor subsided with time. To the best of our knowledge, this is the first functional ultrasound study to show the neurovascular activation of harmaline-induced tremor and the therapeutic suppression in a rat model. Thus, fUS can be considered a noninvasive imaging method for studying neuronal activities involved in the ET model and its treatment.

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Identification of abnormal closed-loop pathways in patients with MRI-negative pharmacoresistant epilepsy

Bu,

Ren,

Wang

et al. 2024

Brain Imaging and Behavior

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Closing the loop: Novel quantitative fMRI approach for manipulation of the sensorimotor loop in tremor

Cited by 3 publications

References 53 publications

Identification of abnormal closed-loop pathways in patients with MRI-negative drug-resistant epilepsy

Identification of abnormal closed-loop pathways in patients with MRI-negative drug-resistant epilepsy

Mapping Pharmacologically Evoked Neurovascular Activation and Its Suppression in a Rat Model of Tremor Using Functional Ultrasound: A Feasibility Study

Identification of abnormal closed-loop pathways in patients with MRI-negative pharmacoresistant epilepsy

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