The process industry has been at the forefront of manufacturing technology advances, systematically aiming for sustainable process improvements. Generally, improvements come as a result of decision-making processes which may be backed on information from various sources. In fact, decision making in manufacturing operations is indeed complex, as it accounts for different scopes and timescales depending on the aimed activities ranging from strategic business management decisions (long term decisions) to basic regulatory control of the process (automatic actions). Despite that, actual deployment of integrated decision support systems remains atypical in process industries, which constraints the potential of optimal operation of assets. This thesis focuses primarily on advanced and supervisory control tools, which typically translates into plant-wide decisions at timescales from minutes (advanced control) to hours (supervisory control).