Closed-loop control of circulating drug levels in live animals

Mage, Peter L.; Ferguson, Blake; Maliniak, Dan; Ploense, Kyle L.; Kippin, Tod E.; Soh, H. Tom

doi:10.1038/s41551-017-0070

Cited by 90 publications

(83 citation statements)

References 56 publications

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“…3 A iii). In a follow-up study, the microchip was integrated into a closed-loop system for precise control of drug concentrations in vivo [ 50 , 51 ]. This was fabricated by equipping the sensor with a controller and an infusion pump.…”

Section: Ex Vivo Biosensing Technologies For Continuous Drug Monitorimentioning

confidence: 99%

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Towards wearable and implantable continuous drug monitoring: A review

Bian

Zhu

Rong

et al. 2021

Journal of Pharmaceutical Analysis

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Continuous drug monitoring is a promising alternative to current therapeutic drug monitoring strategies and has strong potential to reshape our understanding of pharmacokinetic variability and to improve individualised therapy. This review highlights recent advances in biosensing technologies that support continuous drug monitoring in real time. We focus primarily on aptamer-based biosensors, wearable and implantable devices. Emphasis is given to the approaches employed in constructing biosensors. We pay attention to sensors’ biocompatibility, calibration performance, long-term characteristics stability and measurement quality. In the end, we discuss about the current challenges and issues to address in continuous drug monitoring to make it a promising, future tool for individualised therapy. The ongoing efforts are expected to result in fully integrated implantable drug biosensing technology. Thus, we may anticipate an era of advanced healthcare in which wearable and implantable biochips automatically adjust drug dosing in response to patient health conditions enabling the management of diseases and enhancing individualised therapy.

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Section: Ex Vivo Biosensing Technologies For Continuous Drug Monitorimentioning

confidence: 99%

“…Following infusion and sampling, doxorubicin concentrations were sensed in real time and analyzed by the feedback controller. The controller automatically modulated the drug infusion rate to maintain in vivo drug levels at a target value [ 50 ]. …”

Section: Ex Vivo Biosensing Technologies For Continuous Drug Monitorimentioning

confidence: 99%

Towards wearable and implantable continuous drug monitoring: A review

Bian

Zhu

Rong

et al. 2021

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

show abstract

“…They were able to track the chemicals in live rats over multiple hours in real‐time and envisioned that this system could be applied to human patients 16e. They further improved the system by utilizing generalizable closed‐loop approach to both monitor doxorubicin continuously and adjust the concentration of the drug in live rabbits . Other than small molecules, detection of some metal ions through microfluidic systems has also been explored .…”

Section: Microfluidic Selection Of Aptamersmentioning

confidence: 99%

Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application

et al. 2019

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The intersection of microfluidics and aptamer technologies holds particular promise for rapid progress in a plethora of applications across biomedical science and other areas. Here, the influence of microfluidics on the field of aptamers, from traditional capillary electrophoresis approaches through innovative modern‐day approaches using micromagnetic beads and emulsion droplets, is reviewed. Miniaturizing aptamer‐based bioassays through microfluidics has the potential to transform diagnostics and embedded biosensing in the coming years.

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“…Soh and colleagues developed such a strategy involving conformation‐shifting aptamers and electrochemical detection . By measuring the concentrations of chemotherapeutics or antibiotics (e.g., doxorubicin, kanamycin) in the bloodstream, they later employed it with a drug infusion pump for closed‐loop control …”

Section: Nucleic‐acid‐based Sensors For Functional Gene Monitoringmentioning

confidence: 99%

Functional Imaging with Nucleic‐Acid‐Based Sensors: Technology, Application and Future Healthcare Prospects

et al. 2018

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Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications.

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Closed-loop control of circulating drug levels in live animals

Cited by 90 publications

References 56 publications

Towards wearable and implantable continuous drug monitoring: A review

Towards wearable and implantable continuous drug monitoring: A review

Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application

Functional Imaging with Nucleic‐Acid‐Based Sensors: Technology, Application and Future Healthcare Prospects

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