Close Similarity between Sequences of Hepatitis E Virus Recovered from Humans and Swine, France, 2008−2009

Bouquet, Jérôme; Tessé, Sophie; Lunazzi, Aurélie; Éloit, Marc; Rose, Nicolas; Nicand, Élisabeth; Pavio, Nicole

doi:10.3201/eid1711.110616

Cited by 94 publications

(88 citation statements)

References 36 publications

(53 reference statements)

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“…Subtype 3f HEV is the most common subtype in France and Europe (4,22,40) and has been shown to be circulating actively between humans and swine (4). This subtype was selected to study the effect of an interspecies transmission on the genomic adaptation of HEV in its full-length consensus sequence and its quasispecies.…”

Section: Discussionmentioning

confidence: 99%

Identical Consensus Sequence and Conserved Genomic Polymorphism of Hepatitis E Virus during Controlled Interspecies Transmission

Bouquet

Cheval

Rogée

et al. 2012

J Virol

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High-throughput sequencing of bile and feces from two pigs experimentally infected with human hepatitis E virus (HEV) of genotype 3f revealed the same full-length consensus sequence as in the human sample. Twenty-nine percent of polymorphic sites found in HEV from the human sample were conserved throughout the infection of the heterologous host. The interspecies transmission of HEV quasispecies is the result of a genomic negative-selection pressure on random mutations which can be deleterious to the viral population. HEV intrahost nucleotide diversity was found to be in the lower range of other human RNA viruses but correlated with values found for zoonotic viruses. HEV transmission between humans and pigs does not seem to be modulated by host-specific mutations, suggesting that adaptation is mainly regulated by ecological drivers.

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Section: Discussionmentioning

confidence: 99%

Identical Consensus Sequence and Conserved Genomic Polymorphism of Hepatitis E Virus during Controlled Interspecies Transmission

Bouquet

Cheval

Rogée

et al. 2012

J Virol

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“…and in HIV-infected patients according to CD4 count, gender, or HIV transmission mode (18)(19)(20)(21). HEV genotype 3c identified here is among the most frequently described in autochthonous cases in Europe, including France (4,22,23). Best matches in the NCBI nucleotide sequence database were HEV sequences obtained in France from humans in whom HIV status was not documented, while best matches in our laboratory sequence database were HEV sequences from HIV-negative persons (Fig.…”

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confidence: 98%

Hepatitis B and E Co-Primary Infections in an HIV-1-Infected Patient

et al. 2013

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We report an autochthonous hepatitis E virus (HEV)-hepatitis B virus co-primary infection in a 41-year-old man having sex with men and infected with human immunodeficiency virus (HIV). This case prompts testing for HEV in HIV-infected patients with acute hepatitis even if primary infection with another hepatitis virus is diagnosed. CASE REPORTA 41-year-old man having sex with men (MSM) diagnosed in 1997 with human immunodeficiency virus type 1 (HIV-1) infection (1) presented asthenia, abdominal pain, and dark urine specimens in September 2010. His CD4 ϩ T-lymphocyte count (CD4 count) was 222/mm 3 , and his plasma HIV-1 RNA level was

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“…As with other enteric viruses, HEV may be detected in high concentrations in feces from infected individuals and thus can be detected in raw or treated sewage (5,7). The fecal-oral transmission route within an animal species and from contaminated food or waters to humans has been documented (4,6,8).…”

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confidence: 99%

Bioaccumulation Efficiency, Tissue Distribution, and Environmental Occurrence of Hepatitis E Virus in Bivalve Shellfish from France

Grodzki

Schaeffer

Piquet

et al. 2014

Appl Environ Microbiol

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dHepatitis E virus (HEV), an enteric pathogen of both humans and animals, is excreted by infected individuals and is therefore present in wastewaters and coastal waters. As bivalve molluscan shellfish are known to concentrate viral particles during the process of filter feeding, they may accumulate this virus. The bioaccumulation efficiencies of oysters (Crassostrea gigas), flat oysters (Ostrea edulis), mussels (Mytilus edulis), and clams (Ruditapes philippinarum) were compared at different time points during the year. Tissue distribution analysis showed that most of the viruses were concentrated in the digestive tissues of the four species. Mussels and clams were found to be more sensitive to sporadic contamination events, as demonstrated by rapid bioaccumulation in less than 1 h compared to species of oysters. For oysters, concentrations increased during the 24-h bioaccumulation period. Additionally, to evaluate environmental occurrence of HEV in shellfish, an environmental investigation was undertaken at sites potentially impacted by pigs, wild boars, and human waste. Of the 286 samples collected, none were contaminated with hepatitis E virus, despite evidence that this virus is circulating in some French areas. It is possible that the number of hepatitis E viral particles discharged into the environment is too low to detect or that the virus may have a very short period of persistence in pig manure and human waste.

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Close Similarity between Sequences of Hepatitis E Virus Recovered from Humans and Swine, France, 2008−2009

Cited by 94 publications

References 36 publications

Identical Consensus Sequence and Conserved Genomic Polymorphism of Hepatitis E Virus during Controlled Interspecies Transmission

Identical Consensus Sequence and Conserved Genomic Polymorphism of Hepatitis E Virus during Controlled Interspecies Transmission

Hepatitis B and E Co-Primary Infections in an HIV-1-Infected Patient

Bioaccumulation Efficiency, Tissue Distribution, and Environmental Occurrence of Hepatitis E Virus in Bivalve Shellfish from France

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