Close relation of arterial ICC‐like cells to the contractile phenotype of vascular smooth muscle cell

Pucovský, Vladimír; Harhun, Maksym I.; Povstyan, Oleksandr V.; Gordienko, Dmitri; Moss, R.E.; Bolton, T. B.

doi:10.1111/j.1582-4934.2007.00066.x

Cited by 24 publications

(50 citation statements)

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“…The morphological characteristics of ICCs and ICC-LCs have been demonstrated to be species-and tissue-dependent (Burns et al 1997;Komuro 1999;Komuro et al 1999), but most of the gut ICCs are readily stained by methylene blue and express vimentin and the proto-oncogene c-kit (Huizinga et al 1995;Ward et al 1994). In contrast to observations in guinea pig (Pucovsky et al 2003(Pucovsky et al , 2007, ICC-LCs have been positively stained with methylene blue in the rat isolated artery, in freshly dispersed cells, and in primary-cultured cells. In the artery, a dense network of positive blue ICC-LCs has been distinguished in the adventitial side of the media, compatible with the existence of pacemaking regions (Harhun et al 2005).…”

Section: Methylene Blue Positivitymentioning

confidence: 70%

“…These cells have been called ICC-like cells (ICC-LCs) or, more recently, interstitial cells (ICs; Pucovsky 2010). ICC-LCs have also been identified among the cardiovascular system, viz., in rabbit portal vein (Povstyan et al 2003), guinea pig mesenteric artery (Pucovsky et al 2003(Pucovsky et al , 2007, human aorta, and carotid artery (Bobryshev 2005).…”

Section: Introductionmentioning

confidence: 99%

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Identification and functional response of interstitial Cajal-like cells from rat mesenteric artery

et al. 2011

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Cells with irregular shapes, numerous long thin filaments, and morphological similarities to the gastrointestinal interstitial cells of Cajal (ICCs) have been observed in the wall of some blood vessels. These ICC-like cells (ICC-LCs) do not correspond to the other cell types present in the arterial wall: smooth muscle cells (SMCs), endothelial cells, fibroblasts, inflammatory cells, or pericytes. However, no clear physiological role has as yet been determined for ICC-LCs in the vascular wall. The aim of this study has been to identify and characterize the functional response of ICC-LCs in rat mesenteric arteries. We have observed ICC-LCs and identified them morphologically and histologically in three different environments: isolated artery, freshly dispersed cells, and primary-cultured cells from the arterial wall. Like ICCs but unlike SMCs, ICC-LCs are positively stained by methylene blue. Cells morphologically resembling methylene-blue-positive cells are also positive for the ICC and ICC-LC markers α-smooth muscle actin and desmin. Furthermore, the higher expression of vimentin in ICC-LCs compared with SMCs allows a clear discrimination between these two cell types. At the functional level, the differences observed in the variations of cytosolic free calcium concentration of freshly dispersed SMCs and ICC-LCs in response to a panel of vasoactive molecules show that ICC-LCs, unlike SMCs, do not respond to exogenous ATP and [Arginine](8)-vasopressin.

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Section: Methylene Blue Positivitymentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Identification and functional response of interstitial Cajal-like cells from rat mesenteric artery

et al. 2011

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“…It was recently shown that VICs, which we previously called interstitial cells of Cajal [8;12] or ICC-like cells [33] are present in every blood vessels that we worked with. These include portal vein and mesenteric and cerebral arteries of rabbit, portal vein, aorta and pulmonary, mesenteric, kidney, coronary and cerebral arteries of rat, aorta, mesenteric and cerebral arteries of mouse, cerebral, portal vein, mesenteric and kidney arteries of guinea pig, human mesenteric and gastro omental arteries [10-12;33-38].…”

Section: Resultsmentioning

confidence: 99%

Mitochondrial Ca2+ handling is crucial for generation of rhythmical Ca2+ waves in vascular interstitial cells from rabbit portal vein

Harhun

2015

Cell Calcium

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“…Chilian et al reported approximately 25% of basal coronary vascular resistance to exist in arterial vessels great than 200 µm with a further 20% being evident in vessels of diameter between 100 and 200 µm [63]. Accumulating evidence also suggests that some vessels may also have a type of pacemaker cell [168,319], analogous to the interstitial cells of Cajal seen in the intestinal wall [337,404]. Thus, in considering the local regulation of blood flow, these observations have led to a largely functional description of 'resistance arteries' as referring to all arterial vessels possessing tone (see Christensen and Mulvany [65]).…”

Section: Defining An Arteriole-structural and Functional Considerationsmentioning

confidence: 99%

Local Control of Microvascular Perfusion

Hill¹,

Davis²

2012

Colloquium Series on Integrated Systems Physiology: From Molecule to Function

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Physiology is a scientific discipline devoted to understanding the functions of the body. It addresses function at multiple levels, including molecular, cellular, organ, and system. An appreciation of the processes that occur at each level is necessary to understand function in health and the dysfunction associated with disease. Homeostasis and integration are fundamental principles of physiology that account for the relative constancy of organ processes and bodily function even in the face of substantial environmental changes. This constancy results from integrative, cooperative interactions of chemical and electrical signaling processes within and between cells, organs and systems. This eBook series on the broad field of physiology covers the major organ systems from an integrative perspective that addresses the molecular and cellular processes that contribute to homeostasis. Material on pathophysiology is also included throughout the eBooks. The state-of the-art treatises were produced by leading experts in the field of physiology. Each eBook includes stand-alone information and is intended to be of value to students, scientists, and clinicians in the biomedical sciences. Since physiological concepts are an ever-changing work-in-progress, each contributor will have the opportunity to make periodic updates of the covered material.Published titles (for future titles please see the website, AbStrACtLocal control of microvascular perfusion refers to the ability of individual tissues to maintain a relative constancy of hemodynamics in the face of changing perfusion pressure while meeting metabolic demands appropriately. The regulation of local blood flow, or autoregulation, and its underlying mechanisms have been a subject of considerable interest for over 100 years. Particular focus has been placed on the acute interaction of myogenic (pressure-induced) and metabolic (local production of vasodilator metabolites) parameters and how they interact with flow (shear stress)-dependent and conduction-based mechanisms to produce integrated local vascular network responses (for example, as seen during reactive and functional hyperemia). This monograph discusses each of these vasoregulatory phenomena while also considering evidence for their underlying cellular mechanisms. Further, an attempt is made to integrate the information into complex in vivo situations and consider their relevance to pathophysiological situations. vi

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Close relation of arterial ICC‐like cells to the contractile phenotype of vascular smooth muscle cell

Abstract: This work aimed to establish the lineage of cells similar to the interstitial cells of Cajal (ICC), the arterial ICC-like (AIL) cells, which have recently been described in resistance arteries

Cited by 24 publications

References 46 publications

Identification and functional response of interstitial Cajal-like cells from rat mesenteric artery

Identification and functional response of interstitial Cajal-like cells from rat mesenteric artery

Mitochondrial Ca2+ handling is crucial for generation of rhythmical Ca2+ waves in vascular interstitial cells from rabbit portal vein

Local Control of Microvascular Perfusion

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