Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Tanaka, Yoshiro; Nagoshi, Tomohisa; Kikuchi, Makoto; Uno, Goki; Ito, Satoshi; Yoshii, Akira; Kimura, Haruka; Inoue, Yasunori; Ogawa, Kazuo; Tanaka, Toshikazu; Minai, Kosuke; Ogawa, Takayuki; Yoshimura, Michihiro

doi:10.1038/s41598-017-02707-y

Cited by 18 publications

(28 citation statements)

References 42 publications

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“…43,44 Uric Acid A number of studies indicated a significant association between high UA levels and cardiac functions in patients with cardiovascular disease. [23][24][25] However, our study showed that UA levels did not correlate with morphology, LVEF, or GLS in disease-free obese adolescents, even though higher levels were observed in obese subjects. These results support the Framingham Heart Study findings demonstrated that UA does not correlate with the risk of cardiovascular disease, at least in men.…”

Section: Leptin and Cardiac Functioncontrasting

confidence: 64%

“…Cicoira et al demonstrated that UA levels correlate with diastolic but not systolic dysfunction in ischemic cardiomyopathy patients, whereas other studies found a relationship between UA levels and LVEF in patients with ischemic heart disease and heart failure. [23][24][25][26] However, the relationship between UA and cardiac functions in healthy obese people has not been studied.…”

Section: Introductionmentioning

confidence: 99%

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<p>Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents</p>

Imerbtham¹,

Thitiwuthikiat²,

Jongjitwimol³

et al. 2020

DMSO

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The purposes of this study were to use speckle tracking echocardiography to confirm the influence of obesity on cardiac functions and to assess their relationships with leptin and uric acid levels in obese adolescents. Methods: Eighty-one participants aged 16-19 years were recruited and classified as either non-obese (n = 30) or obese (n = 51). Global longitudinal strain (GLS), leptin and uric acid levels for each group were assessed and compared. The data from obese participants were then compared based on their leptin levels and analyzed for correlation using regression analysis. Results: The obese group had significantly lower absolute GLS compared to the non-obese group (19.10 ± 0.30 versus 21.10 ± 0.30%, p < 0.001). In obese group, subclinical cardiac dysfunction was worse in the hyperleptinemic group than that of the normoleptinemic group (p = 0.03). Multivariate regression analysis showed that leptin and triglyceride levels were negatively associated with absolute GLS. Leptin could predict the absolute GLS with β = −0.35 (p = 0.02). Conclusion: Subclinical left ventricular systolic dysfunction was found in obese adolescents, while GLS was worse in the hyperleptinemic subjects. Leptin, but not uric acid, levels were associated with a worsening of GLS.

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Section: Leptin and Cardiac Functioncontrasting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

<p>Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents</p>

Imerbtham¹,

Thitiwuthikiat²,

Jongjitwimol³

et al. 2020

DMSO

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“…A P value of >.05 is considered to indicate good path model fit, as are GFI, AGFI, CFI and RMSEA scores of >.95, >.90, >.97 and <0.08, respectively. The covariance structure analysis in which the structural relationships of the observation variables can be provided has been widely used in many studies not only in sociology and economics but also in epidemiology . Therefore, covariance structure analysis was used to examine the mutual relationship between oral hypofunction and physical frailty in this study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of potential clinical cascade between oral hypofunction and physical frailty: Covariance structure analysis in a cross‐sectional study

Hihara

Goto

Ichikawa

2019

J of Oral Rehabilitation

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No report has yet examined the impact of oral hypofunction on physical frailty in relation to intra‐relationships of physical frailty assessment items. The purpose of this study was to verify the potential of a clinical cascade between oral hypofunction and physical frailty, and especially to support the hypothesis that the influence of oral hypofunction on physical frailty is greater than the intra‐relationships among elements of physical frailty and that sex differences significantly affect these relationships. The participants were 272 older adults (101 men and 171 women; mean age 75.1 ± 7.5 years). Maximum occlusal force (MOF) and oral dryness (OD), as indicators of oral hypofunction, and grip strength (GS) and walking speed (WS), as indicators of physical frailty, were measured. Mutual relationship of four variables was verified using covariance structure analysis. In men, three paths from MOF to WS and GS and from WS to GS were confirmed, and those from MOF to WS and from WS to GS were found to be significant (P < .01). In women, three paths from MOF to WS and GS and from WS to GS were also confirmed, as with the men, and those from MOF to WS and from MOF to GS were found to be significant (P < .01). Model adaptability was shown to be good for both men and women. The results suggest our hypothesis was verified, and it is expected that the early detection of oral hypofunction, that is MOF, may be important for assessing physical frailty, especially in women.

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“…The indirect effect was determined by multiplying the path coefficients of the intervening variables. Recently, we reported our research by applying a covariance structure analysis 19–24. In addition, as covariance structure analysis consists partly of the Bayesian estimation method and the Bayesian adaptive trial design, Bayesian structural equation modelling successfully gave a description of this result, and it is expected to be a next-generation statistical procedure for mega-trials 28.…”

Section: Methodsmentioning

confidence: 97%

“…In many areas, covariance structure analysis plays an important role in understanding how the relationships between observed variables might be generated by interaction effects and/or hypothesised latent variables. Recently, we successfully introduced this statistical approach in the cardiovascular field 19–24. The aim of this study is graphically represented in figure 1.…”

Section: Introductionmentioning

confidence: 99%

Association between plasma B-type natriuretic peptide and anaemia in heart failure with or without ischaemic heart disease: a retrospective study

et al. 2019

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ObjectivesAnaemia is a risk of worsening heart failure. However, anaemia sometimes remains undetected because the superficial cardiac function does not precisely reflect the adverse impact of anaemia. Plasma B-type natriuretic peptide (BNP) could be helpful in these cases. However, the direct anaemic effects on BNP remain unknown. Herein, we compared the direct effect of anaemia on BNP and left ventricular ejection fraction (LVEF) using an advanced statistical procedure.DesignA retrospective study.SettingSecondary care (cardiology), single-centre study.ParticipantsThe study consisted of 3756 inpatients, including 684 without ischaemic heart disease (IHD) and 3072 with IHD.Primary and secondary outcome measuresRelationship between plasma BNP levels and LVEF values.ResultsA path model was constructed to simultaneously examine the adverse impact of anaemia on LVEF and plasma BNP, allowing for renal function. The path model revealed that LVEF increased in response to low haemoglobin (Hb), and the phenomenon was prominent in non-IHD (standardised regression coefficients (St.β): −0.264, p<0.001) rather than in IHD (St.β: 0.015, p=0.531). However, the response of BNP was commonly observed in both groups (non-IHD St.β: −0.238, IHD St.β: −0.398, p<0.001, respectively). Additionally, this study showed a direct link between low estimated glomerular filtration rate and high BNP independently of LVEF. Incrementally, Bayesian structural equation modelling in covariance structure analysis clearly supported this result. The scatter plots and simple regression analysis revealed that an adequate blood supply was approximately Hb 110 g/L and over in the non-IHD patients, whereas blood was not supplied in sufficient quantities even by Hb 130 g/L in patients with IHD.ConclusionThe current study demonstrated that anaemia was a substantial risk for worsening cardiac overload as estimated by plasma BNP. The anaemic response of LVEF likely changed depending on underlying cardiac disorders (IHD or not). However, the response of BNP was robustly observed.

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Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Cited by 18 publications

References 42 publications

<p>Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents</p>

<p>Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents</p>

Assessment of potential clinical cascade between oral hypofunction and physical frailty: Covariance structure analysis in a cross‐sectional study

Association between plasma B-type natriuretic peptide and anaemia in heart failure with or without ischaemic heart disease: a retrospective study

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