Close association of HLA-B51 in persons with recurrent aphthous stomatitis

Shohat‐Zabarski, Ronit; Kalderon, S.; Klein, Tirza; Weinberger, Abraham

doi:10.1016/0030-4220(92)90294-z

Cited by 42 publications

(35 citation statements)

References 11 publications

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“…The presence of family history has been identified as a risk factor affecting the disease progression and the clinical course in RAS patients. In the literature, positive family history was determined in 42 to 67.3% of patients (10)(11)(12). In our study, consistent with the literature, positive family history was determined in 52.8% of patients.…”

Section: Figure1 Minor Aphthaesupporting

confidence: 91%

A Retrospective Evaluation of Patients with Recurrent Aphthous Stomatitis

Demir¹,

Demır²,

Türkoğlu³

et al. 2017

Haseki

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Aim:To determine the factors in the etiology of recurrent aphthous stomatitis (RAS) and to evaluate patients in the terms of RAS associated systemic disorders especially Behçet's disease. Methods:Patients with RAS, who were followed up in Bartın State Hospital Dermatology Clinic between July 2013 and April 2015, were retrospectively evaluated.Results: A total of 123 patients (86 female, 37 male) were included in this study. Thirteen (106%) patients were children. The mean age of patients was 34.5±14.7 years (range: 8-69 years). Minor aphthous somatitis was the most frequent clinical type (68.3%). Family history was positive in 52.8% of patients. The triggering factors in the etiology of RAS were stress (54.5%), trauma (40.2%), gingivitis (29.3%), food (9.8%), medicines (5.7%), menstruation in female patients (3.3%), and throat infections (2.4%). Nutritional deficiencies were found in 39% of patients. There was a statistically significant difference in attack frequency (p=0.017) and throat infection history (p=0.029) between adults and pediatric patients. Fourteen (11.4%) patients were diagnosed with Behçet's disease. When we compared the RAS patients diagnosed with Behçet's disease and the other RAS patients, a significant difference was found in pathergy test (p<0.001) and ferritin levels (p=0.020).Conclusion:Patients with RAS should be followed up for a long time for systemic disorders, especially for Behçet's disease, accompanying RAS. RAS'li çocuk hastalar ile erişkin hastaları karşılaştırdığımızda atak sıklığı ve boğaz enfeksiyonu (p=0,029) dışında istatistiksel açıdan anlamlı bir fark gözlenmedi. On dört hastaya (%11,4) Behçet hastalığı tanısı konuldu. Behçet hastalığı tanısı alan hastalar ile diğer RAS'li hastaları kıyasladığımızda, paterji pozitifliği (p<0,001) ve ferritin düzeyleri (p=0,020) arasındaki fark istatiksel açıdan anlamlıydı.Sonuç: RAS hastalarını sadece etiyolojik faktörler ve hematinik eksikler açısından değerlendirmek yeterli değildir. Bu hastalar başta Behçet hastalığı başta olmak üzere RAS'nin eşlik ettiği diğer sistemik hastalıklar açısından uzun süre takibe alınmalıdır.

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Section: Figure1 Minor Aphthaesupporting

confidence: 91%

A Retrospective Evaluation of Patients with Recurrent Aphthous Stomatitis

Demir¹,

Demır²,

Türkoğlu³

et al. 2017

Haseki

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“…In some but not all groups, there may be a negative association of RAS with MT2 and MT3 (now the HLA-DO series) that may help differentiate RAS from Behget's syndrome . The close association of both Behget's syndrome and RAS with HLA-B51 (Shohat-Zabarski et al, 1982;Albanidou-Farmaki et al, 1988) suggests a relationship in which this locus may not be the primary locus responsible-rather, some other gene close to those controlling heat shock proteins and tumor necrosis factor (Mizuki et al, 1995).…”

Section: Genetic Basismentioning

confidence: 99%

Recurrent Aphthous Stomatitis

Porter

Scully

Pedersen

1998

Critical Reviews in Oral Biology & Medicine

248

143

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“…20% of the subjects in RAS group,12.7% of the subjects in control group had a family history for recurrent oral ulcers. There are several studies reporting the role of genetics in the etiology of RAS but there is no consensus about the percentage of family history [13][14][15]. There was no correlation between frequency of antibiotic usage and teeth brush habits with history of RAS.…”

Section: Discussionmentioning

confidence: 92%

Relationship of Recurrent Aphthous Stomatitis with Nutritional Habits

Özler¹

2015

Ann Clin Anal Med

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ÖzetAmaç: Bu çalışmada geriatrik hasta grubunda reküren aftöz stomatit(RAS) sıklığı ve oral aftların aile öyküsü, boy, kilo, antibiyotik kullanımı, diş fırçala-ma ve beslenme alışkanlıkları ile ilişkisi araştırıldı. Gereç ve Yöntem: Altmış beş yaş üstü hastalar çalışmaya dahil edildi. Değerlendirme öncesi olgulara oral aftöz ülser tanımı yapıldı ve fotoğraflardan oluşan bir görsel bilgilendime formu sunuldu. Hastaların yaşı,cinsiyeti,boyu ve kilosu not edildi. Ardından RAS öyküsü sorgulandı ve oral aft öyküsü olanların ülser sıklığı, ülser tipi, ül-ser yerleşimi, ülserin neden olduğu subjektif semptom, aile öyküsü, antibiyotik kullanım sıklığı, diş fırçalama alışkanlığı ve beslenme alışkanlıkları bir anket ile değerlendirildi. Bulgular: Seksen hasta çalışmayı tamamladı. Olguların %31, 5' i reküren oral ülser tarifledi. Olguların %44'ü tarafından tanımla-nan ağrı en sık görülen subjektif semptom idi. Olguların % 15'inde aile öyküsü mevcuttu. Antibiyotik kullanım sıklığı ile RAS öyküsü arasında korelasyon saptanmadı. Aynı zamanda, diş fırçalama alışkanlığı ile RAS arasında da korelasyon saptanmadı. RAS' lı grup çay ve asitli içecekleri daha sık tüketirken,süt ve süt ürünlerini, cevizi, ekmek ve diğer tahılları daha nadir tüketmekteydi. Tartışma: Beslenme alışkanlıkları reküren aftöz ülser oluşumunda rol oynayabilir.Bu nedenle riskli besinlerin alımının kesilmesi ve koruyucu besinlerin eklenmesi tedavi periyodunun ilk adımı olabilir. Anahtar KelimelerGeriatrik Hastalar; Reküren Aftöz Stomatit(RAS); Beslenme Abstract Aim: In this study we investigated the frequency and relationship of recurrent aphthous stomatitis(RAS) with family history, personal variables such as weight, heigt, antibiotic usage, teeth brush and nutritional habits in geriatric patients. Material and Method: The patients over 65 years old were included in the study. Before examination, the definition of recurrent oral aphthous ulcers and a visual informatory form including photographs were presented to the subjects. The age, sex, height, weight of the subjects were noted on a chart. Then the history of recurrent oral aphthous ulcerations were asked and if present the frequency of the ulcers, the type of the ulcers, the localization of the ulcers, the subjective symptome of the ulcers, familial history for the ulcers, frequency of antibiotic usage, teeth brush habits and nutritional habits were examined by a questionnaire. Results: Eighty subjects completed the study. 31.25% of subjects declared recurrent oral ulcer history. Pain was the leading subjective symptome declared by 44% of the subjects. 15% of the subjects had a family history for recurrent oral ulcers. There was no correlation between frequency of antibiotic usage and history of RAS. Also, there was no correlation between teeth brush habits and history of RAS. The RAS group consumed tea and fizzdrinks more frequently whereas they consumed milk and milk products, walnut, bread and other grains more rarely. Discussion: Nutritional habits may have a role on ocurrence of reccurrent oral apht...

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Close association of HLA-B51 in persons with recurrent aphthous stomatitis

Cited by 42 publications

References 11 publications

A Retrospective Evaluation of Patients with Recurrent Aphthous Stomatitis

A Retrospective Evaluation of Patients with Recurrent Aphthous Stomatitis

Recurrent Aphthous Stomatitis

Relationship of Recurrent Aphthous Stomatitis with Nutritional Habits

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